Publication Beamlines Strategic Pillar
Mizuno, Yutaka; Moorhead, Greg B.G.; Ng, Kenneth K.-S. (2007). Structural Basis for the Regulation of N-Acetylglutamate Kinase by PII in Arabidopsis thaliana. Journal of Biological Chemistry 282(49) , 35733-35740. 10.1074/jbc.m707127200. [PDB: 2rd5] CMCF-ID Health
Zheng, Xiaozhang; Baumeister, Timm; Buckmelter, Alexandre J.; Caligiuri, Maureen; Clodfelter, Karl H. et al. (2014). Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorganic and Medicinal Chemistry Letters 24(1) , 337-343. 10.1016/j.bmcl.2013.11.006. [PDB: 4lww] CMCF-ID Health
Lewis, Melissa; Meza-Avina, Maria Elena; Wei, Lianhu; Crandall, Ian E.; Bello, Angelica Mara et al. (2011). Novel Interactions of Fluorinated Nucleotide Derivatives Targeting Orotidine 5′-Monophosphate Decarboxylase. Journal of Medicinal Chemistry 54(8) , 2891-2901. 10.1021/jm101642g. [PDB: 3mo7] CMCF-ID Health
Sarhan, Maen F.; Tung, Ching-Chieh; Van Petegem, Filip; Ahern, Christopher A. (2012). Crystallographic basis for calcium regulation of sodium channels. Proceedings of the National Academy of Sciences of the United States of America 109(9) , 3558-3563. 10.1073/pnas.1114748109. [PDB: 4djc] CMCF-ID Health
Johnson, Ted W.; Richardson, Paul F.; Bailey, Simon; Brooun, Alexei; Burke, Benjamin J. et al. (2014). Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations. Journal of Medicinal Chemistry 57(11) , 4720-4744. 10.1021/jm500261q. [PDB: 4ctb] CMCF-ID Health
Aljghami, Mazen E.; Morey, Trevor M.; Mabanglo, Mark F.; Meyrick, Jonathan J.; Thomas, Huw B. et al. (2026). Identification of substrates of the human mitochondrial ClpXP protease and its implications for Perrault syndrome. Nature Communications . 10.1038/s41467-026-77888-0. CMCF-BM Health
Sychantha, David; Chen, Xuefei; Koteva, Kalinka; Prehna, Gerd; Wright, Gerard D. et al. (2024). Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes. Nature Communications 15(1) . 10.1038/s41467-024-48232-1. CMCF-BM Health
Szabla, Robert; Li, Mingyi; Warner, Victoria; Song, Yifeng; Junop, Murray et al. (2024). DdrC, a unique DNA repair factor from D. radiodurans, senses and stabilizes DNA breaks through a novel lesion-recognition mechanism. Nucleic Acids Research 52(15) , 9282-9302. 10.1093/nar/gkae635. CMCF-BM, CMCF-ID Health
Dolgova, Natalia; Uhlemann, Eva-Maria E; Boniecki, Michal T; Vizeacoumar, Frederick S; Ara, Anjuman et al. (2024). MEMO1 binds iron and modulates iron homeostasis in cancer cells. eLife 13. 10.7554/elife.86354. CMCF-BM, CMCF-ID Health
Tran, Thi Thanh Quynh; Narayanan, Chitra; Loes, Andrea N.; Click, Timothy H.; Pham, N.T.Hang et al. (2024). Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases. Journal of Biological Chemistry 300(5) , 107280. 10.1016/j.jbc.2024.107280. CMCF-BM Health
Frigon, Léonie; Pascal, John M. (2025). Crystal structure and mutagenesis of a nucleic acid–binding BRCT domain in human PARP4. Journal of Biological Chemistry 301(6) , 110277. 10.1016/j.jbc.2025.110277. CMCF-BM Health
Chatterjee, Som; Poon, Raymond; Satishkumar, Nidhi; Mosimann, Wesley; Hayatnagarkar, Vedangi et al. (2026). Stk1 is required for BlaR1-mediated broad-spectrum β-lactam resistance in epidemic-causing strains of Staphylococcus aureus. Materials & Design . 10.21203/rs.3.rs-8331258/v1. [PDB: 9ymt] CMCF-BM Health
Merchant, Rohan R.; Chernyak, Natalia; Lopez, Jovan A.; Sharp, Phillip P.; Mandal, Mihir et al. (2026). N -Alkyl and N -Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors. ACS Medicinal Chemistry Letters 17(3) , 744-749. 10.1021/acsmedchemlett.6c00066. [PDB: 10qs] CMCF-BM Health
Vara, Brandon A.; Lim, Jongwon; Moure, Casey J.; Schneider, Sebastian E.; Yeung, Charles S. et al. (2026). Discovery and In Vivo Evaluation of Aryl Ether YAP1/TEAD Inhibitors for the Treatment of Hippo-Driven Malignancies. Journal of Medicinal Chemistry 69(4) , 4303-4316. 10.1021/acs.jmedchem.5c02997. [PDB: 9yk2] CMCF-BM Health
Pham, N. T. Hang; Paré, Alex; Létourneau, Myriam; Fortier, Marlène; Chatenet, David et al. (2026). Network‐based allosteric analysis of galectin‐7: Key residues dictate functional communication and stability. Protein Science 35(3) . 10.1002/pro.70502. [PDB: 7n4o, 7n6c, 7n96] CMCF-BM Health