Publication Beamlines Strategic Pillar
Raheem, Izzat T.; Walji, Abbas M.; Klein, Daniel; Sanders, John M.; Powell, David A. et al. (2015). Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors. Journal of Medicinal Chemistry 58(20) , 8154-8165. 10.1021/acs.jmedchem.5b01037. [PDB: 4ztf] CMCF-ID Health
Parker, Michelle L.; Penarete-Vargas, Diana M.; Hamilton, Phineas T.; Guérin, Amandine; Dubey, Jitender P. et al. (2015). Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA–RON2 pair. Proceedings of the National Academy of Sciences of the United States of America 113(2) , 398-403. 10.1073/pnas.1515898113. [PDB: 4z80, 4z81] CMCF-ID Health
Ndubaku, Chudi O.; Crawford, James J.; Drobnick, Joy; Aliagas, Ignacio; Campbell, David et al. (2015). Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety. ACS Medicinal Chemistry Letters 6(12) , 1241-1246. 10.1021/acsmedchemlett.5b00398. CMCF-ID Health
Heald, Robert; Bowman, Krista K.; Bryan, Marian C.; Burdick, Daniel; Chan, Bryan et al. (2015). Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study. Journal of Medicinal Chemistry 58(22) , 8877-8895. 10.1021/acs.jmedchem.5b01412. [PDB: 5cal, 5cao, 5cap] CMCF-ID Health
Gregg, Katie J.; Suits, Michael D.L.; Deng, Lehua; Vocadlo, David J.; Boraston, Alisdair B. et al. (2015). Structural Analysis of a Family 101 Glycoside Hydrolase in Complex with Carbohydrates Reveals Insights into Its Mechanism. Journal of Biological Chemistry 290(42) , 25657-25669. 10.1074/jbc.m115.680470. CMCF-ID Health
Concha, Nestor O.; Smallwood, Angela; Bonnette, William; Totoritis, Rachel; Zhang, Guofeng et al. (2015). Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1αEndoribonuclease Activity. Molecular Pharmacology 88(6) , 1011-1023. 10.1124/mol.115.100917. [PDB: 4yzd] CMCF-ID Health
Blackler, Ryan J; Evans, Dylan W; Smith, David F; Cummings, Richard D; Brooks, Cory L et al. (2015). Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishesN-glycan phosphorylation in a branch-specific manner. Glycobiology 26(2) , 181-192. 10.1093/glycob/cwv093. [PDB: 4rzc] CMCF-ID Health
Baker, Perrin; Whitfield, Gregory B.; Hill, Preston J.; Little, Dustin J.; Pestrak, Matthew J. et al. (2015). Characterization of the Pseudomonas aeruginosa Glycoside Hydrolase PslG Reveals That Its Levels Are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation. Journal of Biological Chemistry 290(47) , 28374-28387. 10.1074/jbc.m115.674929. [PDB: 5bxa] CMCF-ID Health
Alaidi; Osama (2015). Structural characterization of Gemini-based nanoparticles for delivery of DNA. Supervisor: Grochulski, Pawel; Badea, Ildiko. Saskatchewan: University of Saskatchewan. http://hdl.handle.net/10388/ETD-2014-05-1619. CMCF-BM, CMCF-ID Health
Alaidi; Osama (2015). Structural characterization of Gemini-based nanoparticles for delivery of DNA. Supervisor: Grochulski, Pawel; Badea, Ildiko. Saskatchewan: University of Saskatchewan. http://hdl.handle.net/10388/ETD-2014-05-1619. CMCF-BM, CMCF-ID Health
Eigenbrot, C.; Yu, C. (2015). EGFR kinase (T790M/L858R) with inhibitor compound 15: ~{N}-(7-chloranyl-1~{H}-indazol-3-yl)-7,7-dimethyl-2-(1~{H}-pyrazol-4-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine. Protein Data Bank: 5edq. CMCF-BM Health
Eigenbrot, C.; Yu, C. (2015). EGFR kinase (T790M/L858R) apo. Protein Data Bank: 5edp. CMCF-BM Health
Bergeret, F.; Argyropoulos, P.; Boddy, C.N.; Schmeing, T.M. (2015). Crystal structure of the thioesterase domain of deoxyerythronolide B synthase. Protein Data Bank: 5d3k. CMCF-BM Health
Whittington, D.A.; Tang, J.; Yakowec, P. (2015). Crystal structure of human PI3K-gamma in complex with benzimidazole inhibitor 5. Protein Data Bank: 5eds. CMCF-ID Health
Scapin, G.; Prosise, W.; Reichert, P. (2015). Crystal Structure of Pembrolizumab, a full length IgG4 antibody. Protein Data Bank: 5dk3. CMCF-ID Health