Publication Beamlines Strategic Pillar
Weller, Caroline; Burnett, G. Leslie; Jiang, Lingyan; Chakraborty, Sujata; Zhang, Dongyu et al. (2025). A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors. Science 389(6758) . 10.1126/science.ads0239. [PDB: 9ct7, 9ct9, 9cta, 9ctb] CMCF-ID Agriculture
Petzold, Georg; Gainza, Pablo; Annunziato, Stefano; Lamberto, Ilaria; Trenh, Peter et al. (2025). Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition. Science 389(6755) . 10.1126/science.adt6736. [PDB: 9nfr] CMCF-ID Agriculture
Bian, Zhiguo; Schmidt, Robert G.; Wilson, Noel S.; Duignan, David B.; Breinlinger, Eric et al. (2025). Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators. Journal of Medicinal Chemistry 68(14) , 14357-14383. 10.1021/acs.jmedchem.5c00323. [PDB: 9ojs, 9ok6] CMCF-ID Agriculture
Zhang, D.; Saldajeno-Concar, M.; Tomlinson, A.C.A.; Yano, J.K.; Knox, J.E. et al. (2025). Tricomplex of RMC-9945, KRAS G12D, and CypA. Protein Data Bank: 9cta. CMCF-ID Agriculture
Zhang, D.; Bar Ziv, T.; Tomlinson, A.C.A.; Saldajeno-Concar, M.; Yano, J.K. et al. (2025). Tri-complex of zoldonrasib (RMC-9805), KRAS G12D, and CypA. Protein Data Bank: 9ctb. CMCF-ID Agriculture