| Wagner, Florence F.; Benajiba, Lina; Campbell, Arthur J.; Weïwer, Michel; Sacher, Joshua R. et al. (2018). Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Science Translational Medicine 10(431) , eaam8460. 10.1126/scitranslmed.aam8460. [PDB: 5kpl, 5kpm] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Pandit, J. (2018). Structure of human monoacylglycerol lipase bound to a covalent inhibitor. Protein Data Bank: 6bq0. |
CMCF-ID |
PDB Deposition |
Health |
| McAllister, Laura A.; Butler, Christopher R.; Mente, Scot; O’Neil, Steven V.; Fonseca, Kari R. et al. (2018). Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. Journal of Medicinal Chemistry 61(7) , 3008-3026. 10.1021/acs.jmedchem.8b00070. [PDB: 6bq0] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Xu, Chao; Liu, Ke; Lei, Ming; Yang, Ally; Li, Yanjun et al. (2018). DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. Structure 26(1) , 85-95.e3. 10.1016/j.str.2017.11.022. [PDB: 5w9q] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Dranow, D.M.; Abendroth, J.; Lorimer, D.D. (2018). Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine. Protein Data Bank: 6chd. |
CMCF-ID |
PDB Deposition |
Health |
| Hedges, Jason B.; Kuatsjah, Eugene; Du, Yi-Ling; Eltis, Lindsay D.; Ryan, Katherine S. et al. (2018). Snapshots of the Catalytic Cycle of an O2, Pyridoxal Phosphate-Dependent Hydroxylase. ACS Chemical Biology 13(4) , 965-974. 10.1021/acschembio.8b00039. [PDB: 6c3a, 6c3b, 6c3c, 6c3d] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Seattle Structural Genomics Center for Infectious Disease (SSGCID) (2018). Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-Lysylsulfamoyl Adenosine. Protein Data Bank: 6c86. |
CMCF-ID |
PDB Deposition |
Health |
| Mahoney, S.J. (2018). CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND NR1. Protein Data Bank: 6bt0. |
CMCF-ID |
PDB Deposition |
Health |
| Mahoney, Sarah J.; Narayan, Sridhar; Molz, Lisa; Berstler, Lauren A.; Kang, Seong A. et al. (2018). A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nature Communications 9(1) . 10.1038/s41467-018-03035-z. [PDB: 6bt0] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Howell, P.L.; Junop, M.S. (2018). The core region of PilO from the type IV pilus system of Pseudomonas aeruginosa. Protein Data Bank: 5uvr. |
CMCF-ID |
PDB Deposition |
Health |
| Leighton, T. L.; Mok, M. C.; Junop, M. S.; Howell, P. L.; Burrows, L. L. et al. (2018). Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function. Scientific Reports 8(1) . 10.1038/s41598-018-20925-w. [PDB: 5uvr] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Lei, M.; Tempel, W.; Arrowsmith, C.H.; Bountra, C.; Edwards, A.M. et al. (2018). MBD2 in complex with double-stranded DNA. Protein Data Bank: 6c1v. |
CMCF-ID |
PDB Deposition |
Health |
| Lei, M.; Tempel, W.; Arrowsmith, C.H.; Bountra, C.; Edwards, A.M. et al. (2018). MBD2 in complex with a deoxy-oligonucleotide. Protein Data Bank: 6c1u. |
CMCF-ID |
PDB Deposition |
Health |
| Lei, M.; Tempel, W.; Arrowsmith, C.H.; Bountra, C.; Edwards, A.M. et al. (2018). MBD2 in complex with a partially methylated DNA. Protein Data Bank: 6c1t. |
CMCF-ID |
PDB Deposition |
Health |
| Ereno Orbea, J.; Sicard, T.; Julien, J.-P. (2018). Coltuximab Fab in complex with anti-Kappa VHH domain. Protein Data Bank: 6ani. |
CMCF-ID |
PDB Deposition |
Health |