| Hamdorf, Matthias; Imhof, Thomas; Bailey-Elkin, Ben; Betz, Janina; Theobald, Sebastian J et al. (2023). The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm. Journal of Molecular Cell Biology 15(10) . 10.1093/jmcb/mjad062. |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Frigon, Léonie; Pascal, John M (2023). Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP. Nucleic Acids Research . 10.1093/nar/gkad1064. [PDB: 8sx1] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Varkaris, Andreas; Pazolli, Ermira; Gunaydin, Hakan; Wang, Qi; Pierce, Levi et al. (2023). Discovery and clinical proof-of-concept of RLY-2608, a first-in-class mutant-selective allosteric PI3Ka inhibitor that decouples anti-tumor activity from hyperinsulinemia. Cancer Discovery . 10.1158/2159-8290.cd-23-0944. [PDB: 8ts7] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Thai, Elaine; Murugan, Rajagopal; Binter, Špela; Burn Aschner, Clare; Prieto, Katherine et al. (2023). Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Reports 42(11) , 113330. 10.1016/j.celrep.2023.113330. [PDB: 8fb5] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Smith, Christopher R.; Chen, Dan; Christensen, James G.; Coulombe, René; Féthière, James et al. (2023). Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of Medicinal Chemistry 67(1) , 774-781. 10.1021/acs.jmedchem.3c02140. [PDB: 8t5g, 8t5m, 8t5r] |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |