Publication Beamlines Strategic Pillar
Cregg, James; Pota, Kristof; Tomlinson, Aidan C. A.; Yano, Jason; Marquez, Abby et al. (2025). Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02313. [PDB: 9bfv, 9bfw] CMCF-ID Health
Cregg, James; Edwards, Anne V.; Chang, Stephanie; Lee, Bianca J.; Knox, John E. et al. (2025). Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02314. [PDB: 9bg0, 9bg2, 9bg3, 9bg4, 9bg5, 9bg6, 9bg8, 9bga, 9bgb, 9bgc, 9bgd] CMCF-ID Health
Cottrell, Kevin M.; Briggs, Kimberly J.; Tsai, Alice; Tonini, Matthew R.; Whittington, Douglas A. et al. (2025). Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion. Journal of Medicinal Chemistry 68(5) , 5097-5119. 10.1021/acs.jmedchem.4c03067. [PDB: 9n3o] CMCF-BM Health
Colussi, Danielle M.; Grainger, Ryan; Noble, Megan; Lake, Taylor; Junop, Murray et al. (2025). Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb. Computational and Structural Biotechnology Journal 27, 190-213. 10.1016/j.csbj.2024.12.007. [PDB: 8urg] CMCF-BM Health
Chen, Yinshan; Baviriseaty, Sruthika; Thool, Prajwal; Gautreau, Jonah; Yawman, Phillip D. et al. (2025). Quantitative Structural and Compositional Elucidation of Real-World Pharmaceutical Tablet Using Large Field-of-View, Correlative Microscopy-Tomography Techniques and AI-Enabled Image Analysis. Pharmaceutical Research 42(1) , 203-217. 10.1007/s11095-024-03812-0. BMIT-BM Health
Allgayer, Raphaela; Kabir, Reefah Fahmida; Bergeron, Alexandre; Demers, Philippe; Mantovani, Diego et al. (2025). A collagen-based laboratory model to mimic sex-specific features of calcific aortic valve disease. Acta Biomaterialia 194, 204-218. 10.1016/j.actbio.2025.01.034. SXRMB Health
Zhu, Yu-Xiang; Pan, Yuanming; Wang, Lian-Xun; She, Zhenbing; Feng, Renfei et al. (2025). The valence states of Nb and Ta in magmatic-hydrothermal systems: Insights from combined SXAS and XPS analyses of titanite and ilmenite in two Chinese anorogenic suites. American Mineralogist . 10.2138/am-2024-9610. HXMA, VESPERS Environment