Publication Beamlines Strategic Pillar
Poullennec, Karine G.; Jnoff, Eric; Abendroth, Jan; Bhuma, Naresh; Calmiano, Mark et al. (2024). Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies. Journal of Medicinal Chemistry 67(23) , 20879-20910. 10.1021/acs.jmedchem.4c01237. [PDB: 8uoj] CMCF-ID Health
Pushie, M. Jake; Sylvain, Nicole J.; Hou, Huishu; George, Dominic; Kelly, Michael E. et al. (2024). Ion Dyshomeostasis in the Early Hyperacute Phase after a Temporary Large-Vessel Occlusion Stroke. ACS Chemical Neuroscience . 10.1021/acschemneuro.3c00685. MID-IR Health
Pushie, M Jake; Sylvain, Nicole J; Hou, Huishu; Pendleton, Nicole; Wang, Richard et al. (2024). X-ray fluorescence mapping of brain tissue reveals the profound extent of trace element dysregulation in stroke pathophysiology. Metallomics . 10.1093/mtomcs/mfae054. BIOXAS-IMAGING, IDEAS, MID-IR Health
Puumala, Emily; Sychantha, David; Lach, Elizabeth; Reeves, Shawn; Nabeela, Sunna et al. (2024). Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity. Cell Chemical Biology . 10.1016/j.chembiol.2024.01.010. [PDB: 8uk6] CMCF-ID Health
Saran, Anshu; Kim, Hey-Min; Manning, Ireland; Hancock, Mark A; Schmitz, Claus et al. (2024). Unveiling the molecular mechanisms of the type IX secretion system's response regulator: Structural and functional insights. PNAS Nexus 3(8) . 10.1093/pnasnexus/pgae316. [PDB: 8ted] CMCF-BM Health
Sauvé, Véronique; Stefan, Eric; Croteau, Nathalie; Goiran, Thomas; Fakih, Rayan et al. (2024). Activation of parkin by a molecular glue. Nature Communications 15(1) . 10.1038/s41467-024-51889-3. [PDB: 8w31] CMCF-ID Health
Schroeter, Kurt L.; Rolfe, Nicolas; Forrester, Taylor J.B.; Kimber, Matthew S.; Seah, Stephen Y.K. et al. (2024). Shy is a proteobacterial steroid hydratase which catalyzes steroid side chain degradation without requiring a catalytically inert partner domain. Journal of Biological Chemistry 300(8) , 107509. 10.1016/j.jbc.2024.107509. [PDB: 8vwr] CMCF-ID Health
Shurtleff, Valerie W.; Layton, Mark E.; Parish, Craig A.; Perkins, James J.; Schreier, John D. et al. (2024). Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.3c02248. [PDB: 8ute] CMCF-BM Health
Tian, Yuqing; Worrall, Liam J.; Sim, Lyann; Liu, Feng; Nasseri, Seyed A. et al. (2024). Cobalt as a Cofactor for α-Galactosaminidase-Catalyzed Cleavage of Blood Group Antigens. ACS Catalysis 14(17) , 13497-13508. 10.1021/acscatal.4c03643. [PDB: 9awt, 9ay8, 9ayu] CMCF-BM, CMCF-ID Health
Vu, Binh T.; Dominique, Romyr; Fahr, Bruce J.; Li, Hongju H.; Fry, David C. et al. (2024). Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development. ACS Medicinal Chemistry Letters . 10.1021/acsmedchemlett.4c00379. [PDB: 9br4] CMCF-ID Health
Xu, Shangyi; Grochulski, Pawel; Tanaka, Takuji (2024). Structural basis for the allosteric behaviour and substrate specificity of Lactococcus lactis Prolidase. Biochimica et Biophysica Acta - Proteins and Proteomics 1872(3) , 141000. 10.1016/j.bbapap.2024.141000. CMCF-BM, CMCF-ID Health
Zheng, Xiaozhang; Ji, Nan; Campbell, Veronica; Slavin, Anthony; Zhu, Xiao et al. (2024). Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c01305. [PDB: 9cuo] CMCF-ID Health
Zhou, Yuebiao; Aliagas, Ignacio; Wang, Shumei; Li, Chun Sing; Liu, Zhiguo et al. (2024). Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis. Bioorganic and Medicinal Chemistry Letters , 130026. 10.1016/j.bmcl.2024.130026. [PDB: 9dc8, 9dc9] CMCF-BM Health
Zhu, Yuao; Yurgelonis, Irina; Noell, Stephen; Yang, Qingyi; Guan, Shunjie et al. (2024). In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Science Advances 10(30) . 10.1126/sciadv.adl4013. [PDB: 9aum] CMCF-ID Health
Zimmermann, Elizabeth A.; DeVet, Taylor; Cilla, Myriam; Albiol, Laia; Kavaseri, Kyle et al. (2024). Tissue material properties, whole-bone morphology and mechanical behavior in the Fbn1C1041G/+ mouse model of Marfan syndrome. Matrix Biology Plus 23, 100155. 10.1016/j.mbplus.2024.100155. BMIT-BM Health