| Sengupta, Shomit; Giaime, Emilie; Narayan, Sridhar; Hahm, Seung; Howell, Jessica et al. (2019). Discovery of NV-5138, the first selective Brain mTORC1 activator. Scientific Reports 9(1) , 4107. 10.1038/s41598-019-40693-5. [PDB: 6n0m] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| O'Neill, D. (2019). CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138. Protein Data Bank: 6n0m. |
CMCF-ID |
PDB Deposition |
Health |
| Antoshchenko, T.; Chen, Y.; Hughes, S.; Park, H. (2019). Crystal structure of ATPase domain of Human GRP78 bound to Ver155008. Protein Data Bank: 6cz1. |
CMCF-ID |
PDB Deposition |
Health |
| Simonetta, Kyle R.; Taygerly, Joshua; Boyle, Kathleen; Basham, Stephen E.; Padovani, Chris et al. (2019). Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications 10(1) , 1402. 10.1038/s41467-019-09358-9. [PDB: 6m91, 6m92, 6m93, 6m94] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Raman, S.; Beilschmidt, M.; Fransson, J.; Julien, J.P. (2019). Crystal structure of Frizzled 7 CRD in complex with F7.B Fab. Protein Data Bank: 6o3a. |
CMCF-ID |
PDB Deposition |
Health |
| Raman, S.; Beilschmidt, M.; Fransson, J.; Julien, J.P. (2019). Crystal structure of Frizzled 5 CRD in complex with F2.I Fab. Protein Data Bank: 6o39. |
CMCF-ID |
PDB Deposition |
Health |
| Raman, Swetha; Beilschmidt, Melissa; To, Minh; Lin, Kevin; Lui, Francine et al. (2019). Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proceedings of the National Academy of Sciences of the United States of America 116(14) , 6812-6817. 10.1073/pnas.1817246116. [PDB: 6o39, 6o3a] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Li, T.; Lin, S.X. (2019). CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH ESTRONE AND NADP+. Protein Data Bank: 6mne. |
CMCF-ID |
PDB Deposition |
Health |
| Li, Tang; Stephen, Preyesh; Zhu, Dao‐Wei; Shi, Rong; Lin, Sheng‐Xiang et al. (2019). Crystal structures of human 17β‐hydroxysteroid dehydrogenase type 1 complexed with estrone andNADP+reveal the mechanism of substrate inhibition. FEBS Journal 286(11) . 10.1111/febs.14784. [PDB: 6mne] |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
| Simonetta, K.R.; Clifton, M.C.; Walter, R.L.; Ranieri, G.M.; Carter, J.J. et al. (2019). Monophosphorylated pSer33 b-Catenin peptide bound to b-TrCP/Skp1 Complex. Protein Data Bank: 6m94. |
CMCF-ID |
PDB Deposition |
Health |
| Simonetta, K.R.; Clifton, M.C.; Walter, R.L.; Ranieri, G.M.; Lee, S.J. et al. (2019). Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-1933 ternary complex. Protein Data Bank: 6m93. |
CMCF-ID |
PDB Deposition |
Health |
| Simonetta, K.R.; Clifton, M.C.; Walter, R.L.; Ranieri, G.M.; Carter, J.J. et al. (2019). Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2663 ternary complex. Protein Data Bank: 6m92. |
CMCF-ID |
PDB Deposition |
Health |
| Simonetta, K.R.; Clifton, M.C.; Walter, R.L.; Ranieri, G.M.; Carter, J.J. et al. (2019). Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex. Protein Data Bank: 6m91. |
CMCF-ID |
PDB Deposition |
Health |
| Brooks, C.L. (2019). Structure of VHH R419 isolated from a pre-immune phage display library. Protein Data Bank: 6dyx. |
CMCF-ID |
PDB Deposition |
Health |
| Doyle, L.; Mallette, E.; Kimber, M.S. (2019). Escherichia coli KpsC, N-terminal domain. Protein Data Bank: 6mgc. |
CMCF-ID |
PDB Deposition |
Health |