Publication Beamlines Strategic Pillar
Leung, Kevin K. K.; Shilton, Brian H. (2014). Quinone Reductase 2 Is an Adventitious Target of Protein Kinase CK2 Inhibitors TBBz (TBI) and DMAT. Biochemistry 54(1) , 47-59. 10.1021/bi500959t. [PDB: 4u7h] CMCF-ID Health
Leung, Kevin Ka Ki; Litchfield, David W.; Shilton, Brian H. (2012). Flavin adenine dinucleotide content of quinone reductase 2: Analysis and optimization for structure–function studies. Analytical Biochemistry 420(1) , 84-89. 10.1016/j.ab.2011.09.011. CMCF-ID Health
Leung, Chun Yuen; Park, Jaeok; De Schutter, Joris W.; Sebag, Michael; Berghuis, Albert M. et al. (2013). Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition. Journal of Medicinal Chemistry 56(20) , 7939-7950. 10.1021/jm400946f. [PDB: 4jvj, 4l2x] CMCF-ID Health
Leung, Charles Chung Yun; Sun, Luxin; Gong, Zihua; Burkat, Michael; Edwards, Ross et al. (2013). Structural Insights into Recognition of MDC1 by TopBP1 in DNA Replication Checkpoint Control. Structure 21(8) , 1450-1459. 10.1016/j.str.2013.06.015. [PDB: 3ueo] CMCF-ID Health
Leung, Charles Chung Yun; Kellogg, Elizabeth; Kuhnert, Anja; Hänel, Frank; Baker, David et al. (2009). Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIβ binding protein 1. Protein Science , 162-167. 10.1002/pro.290. [PDB: 3jve] CMCF-ID Health
Leung, Charles Chung Yun; Gong, Zihua; Chen, Junjie; Glover, J. N. Mark (2011). Molecular Basis of BACH1/FANCJ Recognition by TopBP1 in DNA Replication Checkpoint Control. Journal of Biological Chemistry 286(6) , 4292-4301. 10.1074/jbc.m110.189555. [PDB: 3al2, 3al3] CMCF-ID Health
Lee, Jaeyong; Taneva, Svetla G.; Holland, Bryan W.; Tieleman, D. Peter; Cornell, Rosemary B. et al. (2014). Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix. Journal of Biological Chemistry 289(3) , 1742-1755. 10.1074/jbc.m113.526970. [PDB: 4mvc, 4mvd] CMCF-BM, CMCF-ID Health
Lee, Jaeyong; Taneva, Svetla G.; Holland, Bryan W.; Tieleman, D. Peter; Cornell, Rosemary B. et al. (2014). Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix. Journal of Biological Chemistry 289(3) , 1742-1755. 10.1074/jbc.m113.526970. [PDB: 4mvc, 4mvd] CMCF-BM, CMCF-ID Health
Lee, Ho Jun; Rakić, Bojana; Gilbert, Michel; Wakarchuk, Warren W.; Withers, Stephen G. et al. (2009). Structural and Kinetic Characterizations of the Polysialic Acid O-Acetyltransferase OatWY from Neisseria meningitidis. Journal of Biological Chemistry 284(36) , 24501-24511. 10.1074/jbc.m109.006049. [PDB: 2wlg] CMCF-ID Health
Lee, Ho Jun; Lairson, Luke L.; Rich, Jamie R.; Lameignere, Emilie; Wakarchuk, Warren W. et al. (2011). Structural and Kinetic Analysis of Substrate Binding to the Sialyltransferase Cst-II from Campylobacter jejuni. Journal of Biological Chemistry 286(41) , 35922-35932. 10.1074/jbc.m111.261172. [PDB: 2x61] CMCF-ID Health
Lazareno-Saez, Christelle; Arutyunova, Elena; Coquelle, Nicolas; Lemieux, M. Joanne (2013). Domain Swapping in the Cytoplasmic Domain of the Escherichia coli Rhomboid Protease. Journal of Molecular Biology 425(7) , 1127-1142. 10.1016/j.jmb.2013.01.019. [PDB: 4hdd] CMCF-ID Health
Lau, Kelvin; Van Petegem, Filip (2014). Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain. Nature Communications 5(1) . 10.1038/ncomms6397. [PDB: 4p9i] CMCF-ID Health
Lang, Shenhui; Cressatti, Marisa; Mendoza, Kris E.; Coumoundouros, Chelsea N.; Plater, Samantha M. et al. (2015). YehZYXW of Escherichia coli Is a Low-Affinity, Non-Osmoregulatory Betaine-Specific ABC Transporter. Biochemistry 54(37) , 5735-5747. 10.1021/acs.biochem.5b00274. [PDB: 4wep] CMCF-ID Health
Kwan, David H.; Constantinescu, Iren; Chapanian, Rafi; Higgins, Melanie A.; Kötzler, Miriam P et al. (2015). Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution. Journal of the American Chemical Society 137(17) , 5695-5705. 10.1021/ja5116088. [PDB: 4d6c, 4d6d, 4d6e, 4d6g] CMCF-BM, CMCF-ID Health
Kwan, David H.; Constantinescu, Iren; Chapanian, Rafi; Higgins, Melanie A.; Kötzler, Miriam P et al. (2015). Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution. Journal of the American Chemical Society 137(17) , 5695-5705. 10.1021/ja5116088. [PDB: 4d6c, 4d6d, 4d6e, 4d6g] CMCF-BM, CMCF-ID Health