Publication Beamlines Strategic Pillar
Leung, Chun Yuen; Park, Jaeok; De Schutter, Joris W.; Sebag, Michael; Berghuis, Albert M. et al. (2013). Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition. Journal of Medicinal Chemistry 56(20) , 7939-7950. 10.1021/jm400946f. [PDB: 4jvj, 4l2x] CMCF-ID Health
Leung, Kevin Ka Ki; Litchfield, David W.; Shilton, Brian H. (2012). Flavin adenine dinucleotide content of quinone reductase 2: Analysis and optimization for structure–function studies. Analytical Biochemistry 420(1) , 84-89. 10.1016/j.ab.2011.09.011. CMCF-ID Health
Leung, Kevin K. K.; Shilton, Brian H. (2014). Quinone Reductase 2 Is an Adventitious Target of Protein Kinase CK2 Inhibitors TBBz (TBI) and DMAT. Biochemistry 54(1) , 47-59. 10.1021/bi500959t. [PDB: 4u7h] CMCF-ID Health
Leung, Kevin K.K.; Shilton, Brian H. (2013). Chloroquine Binding Reveals Flavin Redox Switch Function of Quinone Reductase 2. Journal of Biological Chemistry 288(16) , 11242-11251. 10.1074/jbc.m113.457002. CMCF-ID Health
Lewis, Melissa; Meza-Avina, Maria Elena; Wei, Lianhu; Crandall, Ian E.; Bello, Angelica Mara et al. (2011). Novel Interactions of Fluorinated Nucleotide Derivatives Targeting Orotidine 5′-Monophosphate Decarboxylase. Journal of Medicinal Chemistry 54(8) , 2891-2901. 10.1021/jm101642g. [PDB: 3mo7] CMCF-ID Health
Lewis, Steven M; Wu, Xiufeng; Pustilnik, Anna; Sereno, Arlene; Huang, Flora et al. (2014). Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nature Biotechnology 32(2) , 191-198. 10.1038/nbt.2797. [PDB: 4lld] CMCF-ID Health
Li, Alison Yueh; Lee, Jaeyong; Borek, Dominika; Otwinowski, Zbyszek; Tibbits, Glen F. et al. (2011). Crystal Structure of Cardiac Troponin C Regulatory Domain in Complex with Cadmium and Deoxycholic Acid Reveals Novel Conformation. Journal of Molecular Biology 413(3) , 699-711. 10.1016/j.jmb.2011.08.049. [PDB: 3rv5] CMCF-ID Health
Li, J. W.; Matias, E.; Chen, N.; Kim, C.-Y.; Wang, J. et al. (2010). Investigations of mechanical vibrations for beamlines at the Canadian Light Source. Journal of Synchrotron Radiation 18(2) , 109-116. 10.1107/s0909049510041075. CMCF-ID, REIXS, SM Materials
Lin, Yih-Shyan; Park, Jaeok; De Schutter, Joris W.; Huang, Xian Fang; Berghuis, Albert M. et al. (2012). Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells. Journal of Medicinal Chemistry 55(7) , 3201-3215. 10.1021/jm201657x. [PDB: 4dem] CMCF-ID Health
Little, Dustin J.; Li, Grace; Ing, Christopher; DiFrancesco, Benjamin R.; Bamford, Natalie C. et al. (2014). Modification and periplasmic translocation of the biofilm exopolysaccharide poly-β-1,6- N -acetyl- d -glucosamine. Proceedings of the National Academy of Sciences of the United States of America 111(30) , 11013-11018. 10.1073/pnas.1406388111. [PDB: 4p7q, 4p7r] CMCF-ID Health
Little, Dustin J.; Milek, Sonja; Bamford, Natalie C.; Ganguly, Tridib; DiFrancesco, Benjamin R. et al. (2015). The Protein BpsB Is a Poly-β-1,6-N-acetyl-d-glucosamine Deacetylase Required for Biofilm Formation in Bordetella bronchiseptica. Journal of Biological Chemistry 290(37) , 22827-22840. 10.1074/jbc.m115.672469. [PDB: 5bu6] CMCF-ID Health