Publication Beamlines Strategic Pillar
Sankhe, Safiétou; Fofana, Fatoumata G.; Heiba, Walid; Ogunyemi, Oludare M.; Masisi, Kabo et al. (2025). BioStruct-Africa’s capacity building workshops as a model for advancing the emerging community of structural biologists in Africa. Communications Chemistry 8(1) . 10.1038/s42004-025-01519-w. CMCF Health
Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L. et al. (2025). Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor. Bioorganic and Medicinal Chemistry Letters 124, 130262. 10.1016/j.bmcl.2025.130262. [PDB: 9n9y] CMCF-BM Health
Tong, Yunsong; Baker, Kenton A.; Chapman, Alex M.; Elsen, Nathaniel L.; Fowler, Faith et al. (2025). Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c03029. [PDB: 9og8] CMCF-ID Health
Tran, Norman; Frenette, Aaron; Holyoak, Todd (2025). Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases. Proceedings of the National Academy of Sciences of the United States of America 122(35) . 10.1073/pnas.2503549122. [PDB: 9ekk, 9ekm, 9ekn] CMCF-BM Health
Tran, Norman; Redzic, Jasmina S.; Eisenmesser, Elan Z.; Holyoak, Todd (2025). The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain. Acta Crystallographica Section F:Structural Biology Communications 81(4) . 10.1107/s2053230x25001219. [PDB: 9ect] CMCF-BM Health
Uguen, Mélanie; Shell, Devan J.; Silva, Madhushika; Deng, Yu; Li, Fengling et al. (2025). Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells. Nature Communications 16(1) . 10.1038/s41467-025-57005-3. [PDB: 9cuw, 9cux] CMCF-BM Health
Vallée, Frédéric; Casás-Selves, Matias; Bubenik, Monica; Duplessis, Martin; Sow, Boubacar et al. (2025). Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.5c00529. [PDB: 9o63] CMCF-ID Health
Walker, Morgan E.; Zhu, Wei; Peterson, Janine H.; Wang, Hao; Patteson, Jon et al. (2025). Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition. Nature Communications 16(1) . 10.1038/s41467-025-58086-w. [PDB: 9cs0, 9cs1] CMCF-ID Health
Wang, Mingyu; Du, Grace; Yongo‐Luwawa, Charity; Lu, Angelina; Kinrade, Brett et al. (2025). Peptide‐based ligand antagonists block a Vibrio cholerae adhesin. FEBS Letters . 10.1002/1873-3468.70231. [PDB: 9y9w, 9ybq] CMCF-ID Health
Weller, Caroline; Burnett, G. Leslie; Jiang, Lingyan; Chakraborty, Sujata; Zhang, Dongyu et al. (2025). A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors. Science 389(6758) . 10.1126/science.ads0239. [PDB: 9ct7, 9ct9, 9cta, 9ctb] CMCF-ID Health
Ye, Qilu; Eves, Robert; Vance, Tyler D. R.; Hansen, Thomas; Sage, Adam P. et al. (2025). Aeromonas hydrophila RTX adhesin has three ligand-binding domains that give the bacterium the potential to adhere to and aggregate a wide variety of cell types. mBio 16(5) . 10.1128/mbio.03158-24. [PDB: 9cse] CMCF-ID Health
Khassan, Oleg (2025). Unraveling the Regulation of Plant and Yeast Plastin Proteins: A Structural Determination Study. Supervisor: Haji-Ghassemi, Omid. Alberter, Canada: University of Calgary. https://hdl.handle.net/1880/120616. CMCF Health
LYNSEY CORTNEY BENT (2025). EVALUATING RISK OF LEAD EXPOSURE IN SCAVENGING SPECIES LINKED TO BIGGAME HUNTING IN SASKATCHEWAN, CANADA. Supervisor: Kirsty Gurney. Saskatchewan, Canada: University of Saskatchewan. https://hdl.handle.net/10388/16738. BMIT-ID Health
Marta Girona Alarcón1,+, Willy Kuo1,+, Mattia Humbel2, Christine Tanner2, Luca Fardin3, Britta Bausch1, Yann Decker4, Irene Spera5, Griffin Rodgers2, Hans Deyhle2, Alberto Bravin6, Masato Hoshino7, Arash Panahifar8,9, Kentaro Uesugi7, Sergei Gasilov10, Petr Pleskač11, Yuansheng Zhang1, Diane de Zélicourt1, Amandine Brenna11, Ahmad Kamal Hamid12, Pooya Razzaghi Khamesi1, Britta Engelhardt11, Steven T. Proulx11, Bert Müller2, Vartan Kurtcuoglu (2025). In vivo imaging of central nervous system fluid spaces using synchrotron radiation based micro computed tomography. None. https://arxiv.org/abs/2507.03186. BMIT-ID Health
Jean-Philippe Julien; Taylor Sicard; Anthony Semesi; Bebhinn Treanor; Tiantian Zhao et al. (2025). Nanoparticle platform for antibody and vaccine delivery. Patent Number: US20250114475A1. CMCF-ID Health