Publication Beamlines Strategic Pillar
Cregg, James; Pota, Kristof; Tomlinson, Aidan C. A.; Yano, Jason; Marquez, Abby et al. (2025). Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02313. [PDB: 9bfv, 9bfw] CMCF-ID Health
Daneshamouz, Sana; Saadati, Shaghayegh; Zhu, Sishi; Kalugin, Denis; Shoker, Ahmed et al. (2025). Investigation on the Detoxification of Indoxyl Sulfate (IS) and Indole-3-Acetic Acid (IAA) Protein-Bound Uremic Toxins (PBUTs) Using Trametes versicolor Biocompatible Laccase: In Situ Synchrotron Imaging, Experimental and Computational Studies. Applied Biochemistry and Biotechnology . 10.1007/s12010-025-05235-y. BMIT-ID Health
Ezekiel, Sean J.; Searle, Mackenzie; Park, Jaeok (2025). Engineering dimer mutants of human geranylgeranyl pyrophosphate synthase. PLoS ONE 20(1) , e0317437. 10.1371/journal.pone.0317437. [PDB: 9csl] CMCF-ID Health
Goncalves, Monica M.; Uday, Adwaith B.; Forrester, Taylor J. B.; Currie, S. Quinn W.; Kim, Angelina S. et al. (2025). Mechanism of allosteric activation in human mitochondrial ClpP protease. Proceedings of the National Academy of Sciences of the United States of America 122(16) . 10.1073/pnas.2419881122. [PDB: 9dqk, 9dql] CMCF-ID Health
Ireland, Kendra A.; Kayrouz, Chase M.; Abbott, Marissa L.; Seyedsayamdost, Mohammad R.; Davis, Katherine M. et al. (2025). Structural and functional analysis of SAM-dependent N-methyltransferases involved in ovoselenol and ovothiol biosynthesis. Structure . 10.1016/j.str.2024.12.020. CMCF-ID Health
Kaduk, James A.; Dosen, Anja; Blanton, Thomas N. (2025). Crystal structure of flumethasone, C22H28F2O5. Powder Diffraction , 1-6. 10.1017/s0885715625000120. BXDS-WLE Health
Kaduk, James A.; Dosen, Anja; Blanton, Thomas N. (2025). Crystal structure of diroximel fumarate, C11H13NO6. Powder Diffraction , 1-6. 10.1017/s0885715625000119. BXDS-WLE Health
Kaduk, James A.; Dosen, Anja; Blanton, Thomas N. (2025). Crystal structure of etrasimod, C26H26F3NO3. Powder Diffraction , 1-6. 10.1017/s0885715625000107. BXDS-WLE Health
Kinzel, Olaf; Goldberg, Steven D.; Cummings, Maxwell D.; Gege, Christian; Steeneck, Christoph et al. (2025). Identification of JNJ-61803534, a RORγt Inverse Agonist for the Treatment of Psoriasis. Journal of Medicinal Chemistry 68(8) , 8713-8728. 10.1021/acs.jmedchem.5c00390. [PDB: 9n9l] CMCF-ID Health
Lee, Eunjeong; Tran, Norman; Redzic, Jasmina S.; Singh, Harmanpreet; Alamillo, Lorena et al. (2025). Identifying and controlling inactive and active conformations of a serine protease. Science Advances 11(15) . 10.1126/sciadv.adu7447. [PDB: 9bsh, 9bsm] CMCF-BM Health
Marcozzi, Tatiana; Baviriseaty, Sruthika; Yawman, Phillip; Zhang, Shawn; Vervaet, Chris et al. (2025). Synchrotron computed tomography combined with AI-based image analysis for the advanced characterization of spray dried amorphous solid dispersion particles. Journal of Pharmaceutical Sciences 114(1) , 530-543. 10.1016/j.xphs.2024.10.033. BMIT-BM Health
Mendez, Alex; Bolling, Cydni; Taylor, Shane; Makumire, Stanley; Staker, Bart et al. (2025). Structure of Plasmodium vivax N-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy. Acta Crystallographica Section F:Structural Biology Communications 81(1) , 1-10. 10.1107/s2053230x24011348. [PDB: 5v0w] CMCF-ID Health
Miranda-Zaragoza, Beatriz; Huerta-Miranda, Guillermo A.; García-García, Wendy I.; Hernández-Álvarez, Elizabeth; Solano-Peralta, Alejandro et al. (2025). Structure-Function Relationship of the β-Hairpin of Thermus thermophilus HB27 Laccase. International Journal of Molecular Sciences 26(2) , 735. 10.3390/ijms26020735. [PDB: 9cpm] CMCF-ID Health
Mundboth, Kiran (2025). Canadian Light Source – 20 Years of Discovery. Canadian Journal of Chemistry . 10.1139/cjc-2024-0278. BMIT, BXDS, CMCF, FAR-IR, HXMA, MID-IR, SM Health
Mundboth, Kiran (2025). Canadian Light Source – 20 Years of Discovery. Canadian Journal of Chemistry . 10.1139/cjc-2024-0278. BMIT, BXDS, CMCF, FAR-IR, HXMA, MID-IR, SM Health