| Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L. et al. (2025). Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor. Bioorganic and Medicinal Chemistry Letters 124, 130262. 10.1016/j.bmcl.2025.130262. [PDB: 9n9y] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Lee, Eunjeong; Tran, Norman; Redzic, Jasmina S.; Singh, Harmanpreet; Alamillo, Lorena et al. (2025). Identifying and controlling inactive and active conformations of a serine protease. Science Advances 11(15) . 10.1126/sciadv.adu7447. [PDB: 9bsh, 9bsm] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Cottrell, Kevin M.; Briggs, Kimberly J.; Tsai, Alice; Tonini, Matthew R.; Whittington, Douglas A. et al. (2025). Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion. Journal of Medicinal Chemistry 68(5) , 5097-5119. 10.1021/acs.jmedchem.4c03067. [PDB: 9n3o] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Tran, Norman; Redzic, Jasmina S.; Eisenmesser, Elan Z.; Holyoak, Todd (2025). The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain. Acta Crystallographica Section F:Structural Biology Communications 81(4) . 10.1107/s2053230x25001219. [PDB: 9ect] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Colussi, Danielle M.; Grainger, Ryan; Noble, Megan; Lake, Taylor; Junop, Murray et al. (2025). Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb. Computational and Structural Biotechnology Journal 27, 190-213. 10.1016/j.csbj.2024.12.007. [PDB: 8urg] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Szabla, R.; Junop, M.S.; Wood, K. (2025). Crystal structure of PprA S-F-S tetramer from Deinococcus radiodurans. Protein Data Bank: 9or6. |
CMCF-ID |
PDB Deposition |
Health |
| Pau, V.P.T.; Mao, D.Y.L.; Mader, P.; Maderova, Z.; Zimmermann, M. et al. (2025). Crystal structure of PLK4 and RP1664 complex. Protein Data Bank: 9o63. |
CMCF-ID |
PDB Deposition |
Health |
| Mahbub, L.; Kozlov, G.; Knorn, C.; Gehring, K. (2025). Structure of phosphocysteine intermediate of human PRL1 phosphatase. Protein Data Bank: 9mex. |
CMCF-ID |
PDB Deposition |
Health |
| Ye, Q.; Vance, T.D.R.; Davies, P.L. (2025). Crystal structure of Repeats-in-Toxin-like domain from Aeromonas hydrophila. Protein Data Bank: 9cse. |
CMCF-ID |
PDB Deposition |
Health |
| Spurlino, J.C.; Milligan, C. (2025). An RORgt Inverse agonist for treatment of Psoriasis. Protein Data Bank: 9n9l. |
CMCF-ID |
PDB Deposition |
Health |
| Forrester, T.J.B.; Kimber, M.S. (2025). human ClpP - Bortezomib - A192E / E196R. Protein Data Bank: 9dql. |
CMCF-ID |
PDB Deposition |
Health |
| Forrester, T.J.B.; Kimber, M.S. (2025). human ClpP - Apo - A192E / E196R. Protein Data Bank: 9dqk. |
CMCF-ID |
PDB Deposition |
Health |
| Sawyer, T.K.; Wibowo, A.S.; Carter, J.; Moussa, S.H. (2025). Crystal structure of the catalytic region of human MASP-2 with specific inhibitor Compound S3. Protein Data Bank: 9d4d. |
CMCF-ID |
PDB Deposition |
Health |
| Sawyer, T.K.; Wibowo, A.S.; Carter, J.; Moussa, S.H. (2025). Crystal structure of the catalytic region of human MASP-2 with specific inhibitor Analog 20. Protein Data Bank: 9d40. |
CMCF-ID |
PDB Deposition |
Health |
| Sawyer, T.K.; Wibowo, A.S.; Carter, J.; Moussa, S.H. (2025). Crystal structure of the catalytic region of human MASP-2 with specific inhibitor Compound S2. Protein Data Bank: 9d3y. |
CMCF-ID |
PDB Deposition |
Health |