Publication Beamlines Strategic Pillar
Krishnan, Shreya S; Shen, Yao; O’Hagan, Treasa B; Matthews, Lindsay A; Weerasinghe, Nuwani W et al. (2025). Asymmetric loading of TnsE regulates Tn7 targeting of DNA replication structures. Nucleic Acids Research 53(11) . 10.1093/nar/gkaf472. [PDB: 9d5l] CMCF-BM Health
Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L. et al. (2025). Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor. Bioorganic and Medicinal Chemistry Letters 124, 130262. 10.1016/j.bmcl.2025.130262. [PDB: 9n9y] CMCF-BM Health
Lee, Eunjeong; Tran, Norman; Redzic, Jasmina S.; Singh, Harmanpreet; Alamillo, Lorena et al. (2025). Identifying and controlling inactive and active conformations of a serine protease. Science Advances 11(15) . 10.1126/sciadv.adu7447. [PDB: 9bsh, 9bsm] CMCF-BM Health
Cottrell, Kevin M.; Briggs, Kimberly J.; Tsai, Alice; Tonini, Matthew R.; Whittington, Douglas A. et al. (2025). Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion. Journal of Medicinal Chemistry 68(5) , 5097-5119. 10.1021/acs.jmedchem.4c03067. [PDB: 9n3o] CMCF-BM Health
Tran, Norman; Redzic, Jasmina S.; Eisenmesser, Elan Z.; Holyoak, Todd (2025). The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain. Acta Crystallographica Section F:Structural Biology Communications 81(4) . 10.1107/s2053230x25001219. [PDB: 9ect] CMCF-BM Health
Colussi, Danielle M.; Grainger, Ryan; Noble, Megan; Lake, Taylor; Junop, Murray et al. (2025). Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb. Computational and Structural Biotechnology Journal 27, 190-213. 10.1016/j.csbj.2024.12.007. [PDB: 8urg] CMCF-BM Health
Ivanochko, Danton; Miura, Kazutoyo; Hailemariam, Sophia; Ravichandran, Rashmi; Song, Yiting et al. (2026). A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity. Nature Communications . 10.1038/s41467-026-68761-1. CMCF-ID Health
Haines, Eric; Burke, Michael; Catterall, Rachel; De Jesus, Victor; Hidalgo, Daniel et al. (2026). The MEK–RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers. Nature Cancer . 10.1038/s43018-025-01081-3. [PDB: 9ecu] CMCF-ID Health
Kimani, Serah W.; Noureldin, Mahmoud; Wilson, Brian; Hoffer, Laurent; Green, Stuart R. et al. (2025). OICR-41103 as a chemical probe for the DCAF1 WD40 domain. Communications Biology 8(1) . 10.1038/s42003-025-08491-0. [PDB: 9yv4] CMCF-ID Health
Wang, Mingyu; Du, Grace; Yongo‐Luwawa, Charity; Lu, Angelina; Kinrade, Brett et al. (2025). Peptide‐based ligand antagonists block a Vibrio cholerae adhesin. FEBS Letters . 10.1002/1873-3468.70231. [PDB: 9y9w, 9ybq] CMCF-ID Health
Luo, Chuanyun; Paetzel, Mark (2025). Crystal structure of Escherichia coli type I signal peptidase P84A in complex with lipopeptide antibiotic arylomycin A2. Journal of Structural Biology 217(4) , 108260. 10.1016/j.jsb.2025.108260. [PDB: 9nlo] CMCF-ID Health
Ereño-Orbea, June; Pang, Lijuan; Sicard, Taylor; Nycholat, Corwin; Cui, Hong et al. (2025). Molecular Insights into the Engagement of High-Affinity Sialylated Ligands to Human CD22. JACS Au . 10.1021/jacsau.5c01013. [PDB: 9rm3, 9ro7, 9rob] CMCF-BM, CMCF-ID Health
Bekkering, Ezra T.; Yoo, Randy; Hailemariam, Sophia; Heide, Fabian; Ivanochko, Danton et al. (2025). Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity. Immunity . 10.1016/j.immuni.2025.09.014. [PDB: 9n7k] CMCF-ID Health
Hemmings, Mark; Zieliński, Michał; Golkar, Tolou; Blanchet, Jonathan; Pistofidis, Angelos et al. (2025). Enzyme-mediated aminoglycoside resistance without target mimicry. Communications Chemistry 8(1) . 10.1038/s42004-025-01666-0. [PDB: 9mgu] CMCF-ID Health
Abdoli, Amirabbas; Yang, Zhihan; Odeh‐Ahmed, Abdullah; Bednova, Olga; Lemieux, Bruno et al. (2025). Probing the extent of importin‐α targeting of the TAF8 NLS by eliminating its cationic net‐charge. Protein Science 34(9) . 10.1002/pro.70272. [PDB: 9cl8, 9cle, 9clf, 9clg] CMCF-ID Health