Publication Beamlines Strategic Pillar
Fan, S.; Wei, X.; Lv, R.; Wang, C.; Tang, M. et al. (2025). The Crystal Structure of Glucosyltransferase TcdB from Clostridioides difficile. Protein Data Bank: 8y2l. CMCF-ID Health
Ezekiel, S.; Park, J. (2025). Structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D-C247L) in complex with isopentenyl pyrophosphate. Protein Data Bank: 9csl. CMCF-ID Health
Costanzi, E.; Thomsen, M. (2025). The crystal structure of FAN1 Nuclease bound to 5' phosphorylated p(dG)/3'(dT-dT-dT-dT) double flap DNA. Protein Data Bank: 8s5a. CMCF-ID Health
Chen, A.; Tomlinson, A.C.A.; Bieder, R.; Knox, J.E.; Yano, J.K. et al. (2025). Tri-complex of Daraxonrasib (RMC-6236), KRAS G12C, and CypA. Protein Data Bank: 9bga. CMCF-ID Health
Boraston, A.B.; Tingley, J.; Mihalynuk, L.; Abbott, D.W. (2026). Structure of a GH16_17 carrageenase from a metagenomic dataset.. Protein Data Bank: 9efl. CMCF-ID Health
Vara, Brandon A.; Lim, Jongwon; Moure, Casey J.; Schneider, Sebastian E.; Yeung, Charles S. et al. (2026). Discovery and In Vivo Evaluation of Aryl Ether YAP1/TEAD Inhibitors for the Treatment of Hippo-Driven Malignancies. Journal of Medicinal Chemistry 69(4) , 4303-4316. 10.1021/acs.jmedchem.5c02997. [PDB: 9yk2] CMCF-BM Health
Van Schepdael, Matthew; Asakereh, Iman; Colautti, Jake; Gierys, Andrew J.; Sachar, Kartik et al. (2026). Biophysical characterization of Eag chaperones suggests the mechanism of effector transmembrane domain release. Nature Communications . 10.1038/s41467-025-68138-w. [PDB: 9mvg] CMCF-BM Health
Uguen, Mélanie; Shell, Devan J.; Silva, Madhushika; Deng, Yu; Li, Fengling et al. (2025). Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells. Nature Communications 16(1) . 10.1038/s41467-025-57005-3. [PDB: 9cuw, 9cux] CMCF-BM Health
Tran, Norman; Redzic, Jasmina S.; Eisenmesser, Elan Z.; Holyoak, Todd (2025). The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain. Acta Crystallographica Section F:Structural Biology Communications 81(4) . 10.1107/s2053230x25001219. [PDB: 9ect] CMCF-BM Health
Tran, Norman; Frenette, Aaron; Holyoak, Todd (2025). Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases. Proceedings of the National Academy of Sciences of the United States of America 122(35) . 10.1073/pnas.2503549122. [PDB: 9ekk, 9ekm, 9ekn] CMCF-BM Health
Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L. et al. (2025). Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor. Bioorganic and Medicinal Chemistry Letters 124, 130262. 10.1016/j.bmcl.2025.130262. [PDB: 9n9y] CMCF-BM Health
Rolfe, Nicolas; Schroeter, Kurt L.; Forrester, Taylor JB.; Kimber, Matthew S.; Seah, Stephen YK. et al. (2025). Sal is a proteobacterial bile acid aldolase that repurposes key thiolase catalytic residues for retroaldol cleavage of C5 steroid side chains. Journal of Biological Chemistry 301(8) , 110439. 10.1016/j.jbc.2025.110439. [PDB: 9myr] CMCF-BM Health
Rolfe, Nicolas; Myskiw, Dustin; Patton, Matthew T.; Forrester, Taylor J. B.; Kimber, Matthew S. et al. (2025). Sad from Proteobacteria is a Structurally Distinct ALDH3 Enzyme Specialized for the Oxidation of Steroidal Aldehydes. Biochemistry 64(17) , 3735-3744. 10.1021/acs.biochem.5c00213. [PDB: 9nxl] CMCF-BM Health
Pham, N. T. Hang; Paré, Alex; Létourneau, Myriam; Fortier, Marlène; Chatenet, David et al. (2026). Network‐based allosteric analysis of galectin‐7: Key residues dictate functional communication and stability. Protein Science 35(3) . 10.1002/pro.70502. [PDB: 7n4o, 7n6c, 7n96] CMCF-BM Health
Mellouk, Abdelkader; Ngo, Kenny; Kezzo, Ahmad A.; Martini, Cyrielle; França, Tanos C. C. et al. (2026). Mechanism of trans-envelope bacterial polysaccharide secretion in Class-3 outer-membrane polysaccharide export (OPX) protein systems. Nature Communications . 10.1038/s41467-025-67321-3. [PDB: 9n9a] CMCF-BM Health