| Vallée, Frédéric; Casás-Selves, Matias; Bubenik, Monica; Duplessis, Martin; Sow, Boubacar et al. (2025). Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.5c00529. [PDB: 9o63] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Walker, Morgan E.; Zhu, Wei; Peterson, Janine H.; Wang, Hao; Patteson, Jon et al. (2025). Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition. Nature Communications 16(1) . 10.1038/s41467-025-58086-w. [PDB: 9cs0, 9cs1] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Wang, Mingyu; Du, Grace; Yongo‐Luwawa, Charity; Lu, Angelina; Kinrade, Brett et al. (2025). Peptide‐based ligand antagonists block a
Vibrio cholerae
adhesin. FEBS Letters . 10.1002/1873-3468.70231. [PDB: 9y9w, 9ybq] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Weller, Caroline; Burnett, G. Leslie; Jiang, Lingyan; Chakraborty, Sujata; Zhang, Dongyu et al. (2025). A neomorphic protein interface catalyzes covalent inhibition of RAS
G12D
aspartic acid in tumors. Science 389(6758) . 10.1126/science.ads0239. [PDB: 9ct7, 9ct9, 9cta, 9ctb] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Ye, Qilu; Eves, Robert; Vance, Tyler D. R.; Hansen, Thomas; Sage, Adam P. et al. (2025). Aeromonas hydrophila
RTX adhesin has three ligand-binding domains that give the bacterium the potential to adhere to and aggregate a wide variety of cell types. mBio 16(5) . 10.1128/mbio.03158-24. [PDB: 9cse] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Lu, Jimmy (2025). Mechanistic Insights into Protease Function and Inhibition in Infectious Diseases. Supervisor: Lemieux, M. Joanne. Alberta, Canada: University of Alberta. https://doi.org/10.7939/83361. |
CMCF-BM |
Doctoral Thesis |
Health |
| Frigon, L.; Pascal, J.M. (2025). PARP4 BRCT domain F39A mutant. Protein Data Bank: 9dfr. |
CMCF-BM |
PDB Deposition |
Health |
| Frigon, L.; Pascal, J.M. (2025). PARP4 BRCT domain F39Q mutant. Protein Data Bank: 9dfq. |
CMCF-BM |
PDB Deposition |
Health |
| Frigon, L.; Pascal, J.M. (2025). PARP4 BRCT domain K23/24Q mutant. Protein Data Bank: 9dfp. |
CMCF-BM |
PDB Deposition |
Health |
| Frigon, L.; Pascal, J.M. (2025). PARP4 BRCT domain K31Q mutant. Protein Data Bank: 9dfo. |
CMCF-BM |
PDB Deposition |
Health |
| Grainger, R.; Colussi, D.C.; Noble, M.; Junop, M.; Stathopulos, P.B. et al. (2025). Human mitochondrial calcium uniporter crystal structure (residues 74-165 resolved) with lithium. Protein Data Bank: 8urg. |
CMCF-BM |
PDB Deposition |
Health |
| Holyoak, T.; Tran, N. (2025). Staphylococcus aureus exfoliative toxin A D164E variant. Protein Data Bank: 9bsm. |
CMCF-BM |
PDB Deposition |
Health |
| Holyoak, T.; Tran, N. (2025). Staphylococcus aureus exfoliative toxin A D164A variant. Protein Data Bank: 9bsh. |
CMCF-BM |
PDB Deposition |
Health |
| Kimani, S.; Dong, A.; Hoffmann, L.; Nemec, V.; Ackloo, S. et al. (2025). Crystal structure of the human WDR5 in complex with LH168 compound. Protein Data Bank: 9d5z. |
CMCF-BM |
PDB Deposition |
Health |
| Lai, C.H.R.; Shah, M.; Nguyen, Q.H.; Moraes, T.F. (2025). Crystal structure of a Slam-dependent surface lipoprotein, PmSLP, in Pasteurella multocida. Protein Data Bank: 9b3e. |
CMCF-BM |
PDB Deposition |
Health |