| Cottrell, Kevin M.; Briggs, Kimberly J.; Tsai, Alice; Tonini, Matthew R.; Whittington, Douglas A. et al. (2025). Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion. Journal of Medicinal Chemistry 68(5) , 5097-5119. 10.1021/acs.jmedchem.4c03067. [PDB: 9n3o] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Deschenes, Natalie M; Pérez-Vargas, Jimena; Zhong, Zoe; Thomas, Merrilee; Kenward, Calem et al. (2025). Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance. Journal of Infectious Diseases . 10.1093/infdis/jiaf294. [PDB: 9pfh, 9pfi] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Krishnan, Shreya S; Shen, Yao; O’Hagan, Treasa B; Matthews, Lindsay A; Weerasinghe, Nuwani W et al. (2025). Asymmetric loading of TnsE regulates Tn7 targeting of DNA replication structures. Nucleic Acids Research 53(11) . 10.1093/nar/gkaf472. [PDB: 9d5l] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Lee, Eunjeong; Tran, Norman; Redzic, Jasmina S.; Singh, Harmanpreet; Alamillo, Lorena et al. (2025). Identifying and controlling inactive and active conformations of a serine protease. Science Advances 11(15) . 10.1126/sciadv.adu7447. [PDB: 9bsh, 9bsm] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L. et al. (2025). Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor. Bioorganic and Medicinal Chemistry Letters 124, 130262. 10.1016/j.bmcl.2025.130262. [PDB: 9n9y] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Tran, Norman; Redzic, Jasmina S.; Eisenmesser, Elan Z.; Holyoak, Todd (2025). The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain. Acta Crystallographica Section F:Structural Biology Communications 81(4) . 10.1107/s2053230x25001219. [PDB: 9ect] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Zhao, Feipeng; Zhang, Shumin; Wang, Shuo; Reid, Joel W.; Xia, Wei et al. (2025). Anion sublattice design enables superionic conductivity in crystalline oxyhalides. Science 390(6769) , 199-204. 10.1126/science.adt9678. |
CMCF-BM, SXRMB |
Peer-Reviewed Article |
Materials |
| Chen, P.; Lamer, T.; Vederas, J.C.; Lemieux, M.J. (2025). Crystal structures of a cyanobacterial DAP epimerase bound to D,L-alpha-methyl DAP. Protein Data Bank: 9mrv. |
CMCF-BM |
PDB Deposition |
Agriculture |
| Chen, P.; Lamer, T.; Vederas, J.C.; Lemieux, M.J. (2025). Crystal structures of a cyanobacterial DAP epimerase bound to either D,L-aziDAP or D,L-alpha-methyl DAP. Protein Data Bank: 9mro. |
CMCF-BM |
PDB Deposition |
Agriculture |
| Hemmings, M.; Zielinski, M.; Blanchet, J.; Golkar, T.; Berghuis, A.M. et al. (2025). Structure of aminoglycoside acetyltransferase AAC(3)-Ia in complex with sisomicin and CoA. Protein Data Bank: 9mgs. |
CMCF-BM |
PDB Deposition |
Agriculture |
| Kenward, C.; Mosimann, W.A.; Worrall, L.J.; Strynadka, N.C.J. (2025). Crystal structure of SARS-CoV-2 Mpro Mutant P132H. Protein Data Bank: 9pfi. |
CMCF-BM |
PDB Deposition |
Agriculture |
| Kenward, C.; Mosimann, W.A.; Worrall, L.J.; Strynadka, N.C.J. (2025). Crystal structure of SARS-CoV-2 Mpro Mutant P132H with C5a. Protein Data Bank: 9pfh. |
CMCF-BM |
PDB Deposition |
Agriculture |
| kimani, S.; Dong, A.; Li, Y.; Seitova, A.; Mamai, A. et al. (2025). Crystal structure of the human DCAF1 WDR domain in complex with OICR-40120. Protein Data Bank: 9y76. |
CMCF-BM |
PDB Deposition |
Agriculture |
| Krishnan, S.S.; Guarne, A. (2025). The C-terminal domain of Thiopseudomonas alkaliphila Tn7 TnsE bound to DNA. Protein Data Bank: 9d5l. |
CMCF-BM |
PDB Deposition |
Agriculture |
| Mabanglo, M.F.; Houry, W.A. (2025). Crystal structure of Neisseria meningitidis ClpP protease complex with boronate compound BC8a. Protein Data Bank: 9mjp. |
CMCF-BM |
PDB Deposition |
Agriculture |