Publication Beamlines Strategic Pillar
Tran, Norman; Redzic, Jasmina S.; Eisenmesser, Elan Z.; Holyoak, Todd (2025). The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain. Acta Crystallographica Section F:Structural Biology Communications 81(4) . 10.1107/s2053230x25001219. [PDB: 9ect] CMCF-BM Health
Colussi, Danielle M.; Grainger, Ryan; Noble, Megan; Lake, Taylor; Junop, Murray et al. (2025). Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb. Computational and Structural Biotechnology Journal 27, 190-213. 10.1016/j.csbj.2024.12.007. [PDB: 8urg] CMCF-BM Health
Rolfe, Nicolas; Myskiw, Dustin; Patton, Matthew T.; Forrester, Taylor J. B.; Kimber, Matthew S. et al. (2025). Sad from Proteobacteria is a Structurally Distinct ALDH3 Enzyme Specialized for the Oxidation of Steroidal Aldehydes. Biochemistry 64(17) , 3735-3744. 10.1021/acs.biochem.5c00213. [PDB: 9nxl] CMCF-BM Agriculture
Rolfe, Nicolas; Schroeter, Kurt L.; Forrester, Taylor JB.; Kimber, Matthew S.; Seah, Stephen YK. et al. (2025). Sal is a proteobacterial bile acid aldolase that repurposes key thiolase catalytic residues for retroaldol cleavage of C5 steroid side chains. Journal of Biological Chemistry 301(8) , 110439. 10.1016/j.jbc.2025.110439. [PDB: 9myr] CMCF-BM Agriculture
Dodda, Leela S.; Campos, Sebastien; Ciccone, David; Carreiro, Samantha; Leit, Silvana et al. (2025). Knowledge and Structure-Based Drug Design of 15-PGDH Inhibitors. Journal of Medicinal Chemistry 68(17) , 18436-18462. 10.1021/acs.jmedchem.5c01231. [PDB: 9pfl] CMCF-BM Agriculture
Barghash, Marim M.; Mabanglo, Mark F.; Hoff, Samuel E.; Brozdnychenko, Dmytro; Wong, Keith S. et al. (2025). Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure . 10.1016/j.str.2025.07.013. [PDB: 9mjp] CMCF-BM Agriculture
Tran, Norman; Frenette, Aaron; Holyoak, Todd (2025). Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases. Proceedings of the National Academy of Sciences of the United States of America 122(35) . 10.1073/pnas.2503549122. [PDB: 9ekk, 9ekm, 9ekn] CMCF-BM Agriculture
Frigon, L.; Pascal, J.M. (2025). PARP4 BRCT domain F39A mutant. Protein Data Bank: 9dfr. CMCF-BM Health
Frigon, L.; Pascal, J.M. (2025). PARP4 BRCT domain F39Q mutant. Protein Data Bank: 9dfq. CMCF-BM Health
Frigon, L.; Pascal, J.M. (2025). PARP4 BRCT domain K23/24Q mutant. Protein Data Bank: 9dfp. CMCF-BM Health
Frigon, L.; Pascal, J.M. (2025). PARP4 BRCT domain K31Q mutant. Protein Data Bank: 9dfo. CMCF-BM Health
Whittington, D.A. (2025). Crystal structure of truncated USP1:UAF1 in complex with compound 18. Protein Data Bank: 9n9y. CMCF-BM Health
Holyoak, T.; Tran, N. (2025). Staphylococcus aureus exfoliative toxin A D164E variant. Protein Data Bank: 9bsm. CMCF-BM Health
Holyoak, T.; Tran, N. (2025). Staphylococcus aureus exfoliative toxin A D164A variant. Protein Data Bank: 9bsh. CMCF-BM Health
Lai, C.H.R.; Shah, M.; Nguyen, Q.H.; Moraes, T.F. (2025). Crystal structure of a Slam-dependent surface lipoprotein, PmSLP, in Pasteurella multocida. Protein Data Bank: 9b3e. CMCF-BM Health