| Bian, Zhiguo; Schmidt, Robert G.; Wilson, Noel S.; Duignan, David B.; Breinlinger, Eric et al. (2025). Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators. Journal of Medicinal Chemistry 68(14) , 14357-14383. 10.1021/acs.jmedchem.5c00323. [PDB: 9ojs, 9ok6] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Zhang, D.; Bar Ziv, T.; Tomlinson, A.C.A.; Saldajeno-Concar, M.; Yano, J.K. et al. (2025). Tri-complex of zoldonrasib (RMC-9805), KRAS G12D, and CypA. Protein Data Bank: 9ctb. |
CMCF-ID |
PDB Deposition |
Agriculture |
| Zhang, D.; Saldajeno-Concar, M.; Tomlinson, A.C.A.; Yano, J.K.; Knox, J.E. et al. (2025). Tricomplex of RMC-9945, KRAS G12D, and CypA. Protein Data Bank: 9cta. |
CMCF-ID |
PDB Deposition |
Agriculture |
| Zhang, D.; Bar Ziv, T.; Knox, J.E.; Yano, J.K. (2025). Tricomplex of Compound 3, KRAS G12D, and CypA. Protein Data Bank: 9ct9. |
CMCF-ID |
PDB Deposition |
Agriculture |
| Zhang, D.; Bar Ziv, T.; Knox, J.E.; Yano, J.K. (2025). Tricomplex of Compound 1, KRAS G12D, and CypA. Protein Data Bank: 9ct7. |
CMCF-ID |
PDB Deposition |
Agriculture |
| Weller, Caroline; Burnett, G. Leslie; Jiang, Lingyan; Chakraborty, Sujata; Zhang, Dongyu et al. (2025). A neomorphic protein interface catalyzes covalent inhibition of RAS
G12D
aspartic acid in tumors. Science 389(6758) . 10.1126/science.ads0239. [PDB: 9ct7, 9ct9, 9cta, 9ctb] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Petzold, Georg; Gainza, Pablo; Annunziato, Stefano; Lamberto, Ilaria; Trenh, Peter et al. (2025). Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition. Science 389(6755) . 10.1126/science.adt6736. [PDB: 9nfr] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Trenh, P.; Bunker, R.D.; Lucas, X.; Gainza, P.; Tsai, J.H.C. et al. (2025). Crystal structure of CRBN-DDB1 and MRT-23227 in complex with VAV1. Protein Data Bank: 9nfr. |
CMCF-ID |
PDB Deposition |
Agriculture |
| White, A.; Lakshminarasimhan, D.; Cakici, O.; Suto, R. (2025). Crystal structure of HBV capsid with compound 18. Protein Data Bank: 9n3h. |
CMCF-ID |
PDB Deposition |
Agriculture |
| Liu, Bin; Yao, Jiangchao; Haimowitz, Thomas; Benetatos, Christopher A.; Boyd, Steven A. et al. (2025). Discovery of VNRX-9945, a Potent, Broadly Active Capsid Assembly Modulator as a Clinical Candidate for the Treatment of Chronic Hepatitis B Virus Infection. ACS Medicinal Chemistry Letters . 10.1021/acsmedchemlett.5c00315. [PDB: 9n3h] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Pemberton, O.A.; Tong, Y.; Nocek, B.; Tang, H.Y.H. (2025). Crystal structure of WRN in complex with compound 43. Protein Data Bank: 9og8. |
CMCF-ID |
PDB Deposition |
Health |
| Tong, Yunsong; Baker, Kenton A.; Chapman, Alex M.; Elsen, Nathaniel L.; Fowler, Faith et al. (2025). Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c03029. [PDB: 9og8] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Knudson-Goerner, E.J.; Boraston, A.B. (2025). The structure of a family 168 glycoside hydrolase from the marine bacterium Muricauda eckloniae.. Protein Data Bank: 9nhf. |
CMCF-ID |
PDB Deposition |
Agriculture |
| Knudson-Goerner, Emily; Boraston, Alisdair B. (2025). The structure of a family 168 glycoside hydrolase from the marine bacterium Muricauda eckloniae. Acta Crystallographica Section F:Structural Biology Communications 81(7) . 10.1107/s2053230x2500425x. [PDB: 9nhf] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Thomsen, M.; Costanzi, E. (2025). The crystal structure of DNA-bound human MutSbeta (MSH2_E749A/MSH3_E976A) in the canonical mismatch bound conformation with ADP bound in MSH2. Protein Data Bank: 8rb2. |
CMCF-ID |
PDB Deposition |
Agriculture |