Publication Beamlines Strategic Pillar
Lee, Eunjeong; Redzic, Jasmina S.; Gordon, Blaine; Saviola, Anthony J.; Tran, Norman et al. (2025). Streptococcus pneumoniae HtrA is a dynamic and monomeric virulence factor capable of forming larger oligomeric complexes. Protein Science 35(1) . 10.1002/pro.70411. [PDB: 9pno] CMCF-BM Health
Lee, Eunjeong; Tran, Norman; Redzic, Jasmina S.; Singh, Harmanpreet; Alamillo, Lorena et al. (2025). Identifying and controlling inactive and active conformations of a serine protease. Science Advances 11(15) . 10.1126/sciadv.adu7447. [PDB: 9bsh, 9bsm] CMCF-BM Health
Lin, Funing; Mabanglo, Mark F.; Zhou, Jin Lin; Binepal, Gursonika; Barghash, Marim M. et al. (2024). Structure-Based Design and Development of Phosphine Oxides as a Novel Chemotype for Antibiotics that Dysregulate Bacterial ClpP Proteases. Journal of Medicinal Chemistry 67(17) , 15131-15147. 10.1021/acs.jmedchem.4c00773. [PDB: 8szm, 8szn] CMCF-BM Health
Mabanglo, Mark F.; Wilson, Brian; Noureldin, Mahmoud; Kimani, Serah W.; Mamai, Ahmed et al. (2024). Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity. Nature Communications 15(1) . 10.1038/s41467-024-54500-x. [PDB: 9b9h, 9b9t, 9b9w, 9ba2] CMCF-BM Health
Mellouk, Abdelkader; Ngo, Kenny; Kezzo, Ahmad A.; Martini, Cyrielle; França, Tanos C. C. et al. (2026). Mechanism of trans-envelope bacterial polysaccharide secretion in Class-3 outer-membrane polysaccharide export (OPX) protein systems. Nature Communications . 10.1038/s41467-025-67321-3. [PDB: 9n9a] CMCF-BM Health
Muna, Tasneem Hassan; Rutbeek, Nicole R; Horne, Julia; Lao, Ying W; Krokhin, Oleg V et al. (2024). The phage protein paratox is a multifunctional metabolic regulator of Streptococcus. Nucleic Acids Research . 10.1093/nar/gkae1200. [PDB: 8vsq] CMCF-BM Health
Nasseri, Seyed Amirhossein; Lazarski, Aleksander C.; Lemmer, Imke L.; Zhang, Chloe Y.; Brencher, Eva et al. (2024). An alternative broad-specificity pathway for glycan breakdown in bacteria. Nature . 10.1038/s41586-024-07574-y. [PDB: 8tdi] CMCF-BM Health
Petraccione, Kaylee; Ali, Mohamed G. H.; Cyr, Normand; Wahba, Haytham M.; Stocker, Timothy et al. (2024). An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy. PLoS Pathogens 20(3) , e1012093. 10.1371/journal.ppat.1012093. [PDB: 8t2m] CMCF-BM Health
Pham, N. T. Hang; Paré, Alex; Létourneau, Myriam; Fortier, Marlène; Chatenet, David et al. (2026). Network‐based allosteric analysis of galectin‐7: Key residues dictate functional communication and stability. Protein Science 35(3) . 10.1002/pro.70502. [PDB: 7n4o, 7n6c, 7n96] CMCF-BM Health
Rolfe, Nicolas; Myskiw, Dustin; Patton, Matthew T.; Forrester, Taylor J. B.; Kimber, Matthew S. et al. (2025). Sad from Proteobacteria is a Structurally Distinct ALDH3 Enzyme Specialized for the Oxidation of Steroidal Aldehydes. Biochemistry 64(17) , 3735-3744. 10.1021/acs.biochem.5c00213. [PDB: 9nxl] CMCF-BM Health
Rolfe, Nicolas; Schroeter, Kurt L.; Forrester, Taylor JB.; Kimber, Matthew S.; Seah, Stephen YK. et al. (2025). Sal is a proteobacterial bile acid aldolase that repurposes key thiolase catalytic residues for retroaldol cleavage of C5 steroid side chains. Journal of Biological Chemistry 301(8) , 110439. 10.1016/j.jbc.2025.110439. [PDB: 9myr] CMCF-BM Health
Saran, Anshu; Kim, Hey-Min; Manning, Ireland; Hancock, Mark A; Schmitz, Claus et al. (2024). Unveiling the molecular mechanisms of the type IX secretion system's response regulator: Structural and functional insights. PNAS Nexus 3(8) . 10.1093/pnasnexus/pgae316. [PDB: 8ted] CMCF-BM Health
Shurtleff, Valerie W.; Layton, Mark E.; Parish, Craig A.; Perkins, James J.; Schreier, John D. et al. (2024). Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.3c02248. [PDB: 8ute] CMCF-BM Health
Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L. et al. (2025). Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor. Bioorganic and Medicinal Chemistry Letters 124, 130262. 10.1016/j.bmcl.2025.130262. [PDB: 9n9y] CMCF-BM Health
Tian, Yuqing; Worrall, Liam J.; Sim, Lyann; Liu, Feng; Nasseri, Seyed A. et al. (2024). Cobalt as a Cofactor for α-Galactosaminidase-Catalyzed Cleavage of Blood Group Antigens. ACS Catalysis 14(17) , 13497-13508. 10.1021/acscatal.4c03643. [PDB: 9awt, 9ay8, 9ayu] CMCF-BM, CMCF-ID Health