Publication Beamlines Strategic Pillar
Vallée, Frédéric; Casás-Selves, Matias; Bubenik, Monica; Duplessis, Martin; Sow, Boubacar et al. (2025). Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.5c00529. [PDB: 9o63] CMCF-ID Health
Vu, Binh T.; Dominique, Romyr; Fahr, Bruce J.; Li, Hongju H.; Fry, David C. et al. (2024). Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development. ACS Medicinal Chemistry Letters . 10.1021/acsmedchemlett.4c00379. [PDB: 9br4] CMCF-ID Health
Walker, Morgan E.; Zhu, Wei; Peterson, Janine H.; Wang, Hao; Patteson, Jon et al. (2025). Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition. Nature Communications 16(1) . 10.1038/s41467-025-58086-w. [PDB: 9cs0, 9cs1] CMCF-ID Health
Weller, Caroline; Burnett, G. Leslie; Jiang, Lingyan; Chakraborty, Sujata; Zhang, Dongyu et al. (2025). A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors. Science 389(6758) . 10.1126/science.ads0239. [PDB: 9ct7, 9ct9, 9cta, 9ctb] CMCF-ID Health
Xu, Shangyi; Grochulski, Pawel; Tanaka, Takuji (2024). Structural basis for the allosteric behaviour and substrate specificity of Lactococcus lactis Prolidase. Biochimica et Biophysica Acta - Proteins and Proteomics 1872(3) , 141000. 10.1016/j.bbapap.2024.141000. CMCF-BM, CMCF-ID Health
Ye, Qilu; Eves, Robert; Vance, Tyler D. R.; Hansen, Thomas; Sage, Adam P. et al. (2025). Aeromonas hydrophila RTX adhesin has three ligand-binding domains that give the bacterium the potential to adhere to and aggregate a wide variety of cell types. mBio 16(5) . 10.1128/mbio.03158-24. [PDB: 9cse] CMCF-ID Health
Zheng, Xiaozhang; Ji, Nan; Campbell, Veronica; Slavin, Anthony; Zhu, Xiao et al. (2024). Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c01305. [PDB: 9cuo] CMCF-ID Health
Zhu, Yuao; Yurgelonis, Irina; Noell, Stephen; Yang, Qingyi; Guan, Shunjie et al. (2024). In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance. Science Advances 10(30) . 10.1126/sciadv.adl4013. [PDB: 9aum] CMCF-ID Health
Ali, M.G.H.; Wahba, H.M.; Cyr, N.; Omichinski, J.G. (2024). Crystal structure of GABARAP in complex with the LIR of NSs4. Protein Data Bank: 8t2m. CMCF-BM Agriculture
Chen, P.; Lamer, T.; Vederas, J.C.; Lemieux, M.J. (2025). Crystal structures of a cyanobacterial DAP epimerase bound to D,L-alpha-methyl DAP. Protein Data Bank: 9mrv. CMCF-BM Agriculture
Chen, P.; Lamer, T.; Vederas, J.C.; Lemieux, M.J. (2025). Crystal structures of a cyanobacterial DAP epimerase bound to either D,L-aziDAP or D,L-alpha-methyl DAP. Protein Data Bank: 9mro. CMCF-BM Agriculture
Gunn, R.J.; Lawson, J.D.; Ivetac, A.; Ulaganathan, T.; Coulombe, R. et al. (2024). SOS2 crystal structure with fragment bound (compound 13). Protein Data Bank: 8t5r. CMCF-BM Agriculture
Kenward, C.; Mosimann, W.A.; Worrall, L.J.; Strynadka, N.C.J. (2025). Crystal structure of SARS-CoV-2 Mpro Mutant P132H. Protein Data Bank: 9pfi. CMCF-BM Agriculture
Kenward, C.; Mosimann, W.A.; Worrall, L.J.; Strynadka, N.C.J. (2025). Crystal structure of SARS-CoV-2 Mpro Mutant P132H with C5a. Protein Data Bank: 9pfh. CMCF-BM Agriculture
Penner, T.V.; Prehna, G. (2024). Crystal structure of Sel-1 repeat protein LceB from Legionella pneumophila. Protein Data Bank: 8sxq. CMCF-BM Agriculture