Publication Beamlines Strategic Pillar
Cregg, James; Edwards, Anne V.; Chang, Stephanie; Lee, Bianca J.; Knox, John E. et al. (2025). Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02314. [PDB: 9bg0, 9bg2, 9bg3, 9bg4, 9bg5, 9bg6, 9bg8, 9bga, 9bgb, 9bgc, 9bgd] CMCF-ID Health
Cottrell, Kevin M.; Briggs, Kimberly J.; Whittington, Douglas A.; Jahic, Haris; Ali, Janid A. et al. (2024). Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers. Journal of Medicinal Chemistry 67(8) , 6064-6080. 10.1021/acs.jmedchem.4c00133. [PDB: 8veu] CMCF-ID Health
Bissegger, Lukas; Constantin, Theodora A.; Keles, Erhan; Raguž, Luka; Barlow-Busch, Isobel et al. (2024). Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling. Chemical Science . 10.1039/d4sc05459h. [PDB: 8twy] CMCF-ID Health
Bian, Zhiguo; Schmidt, Robert G.; Wilson, Noel S.; Duignan, David B.; Breinlinger, Eric et al. (2025). Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators. Journal of Medicinal Chemistry 68(14) , 14357-14383. 10.1021/acs.jmedchem.5c00323. [PDB: 9ojs, 9ok6] CMCF-ID Health
Asar, Radwa; Dhindwal, Poonam; Ruzzini, Antonio (2024). Structural and functional analysis of a bile salt hydrolase from the bison microbiome. Journal of Biological Chemistry 300(10) , 107769. 10.1016/j.jbc.2024.107769. [PDB: 8vrx] CMCF-ID Health
Ali, Mohamed G.; Wahba, Haytham M.; Igelmann, Sebastian; Cyr, Normand; Ferbeyre, Gerardo et al. (2024). Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR. Autophagy . 10.1080/15548627.2024.2353443. [PDB: 8t33, 8t4t] CMCF-BM, CMCF-ID Health
Aguilar, Eric N.; Sagar, Satish; Murray, Brandy R.; Rajesh, Christabelle; Lei, Eric K. et al. (2024). Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6. Molecular Cancer Therapeutics 23(6) , 836-853. 10.1158/1535-7163.mct-23-0868. [PDB: 8gkk, 8gkl] CMCF-ID Health
Adachi, Kaoru; Manabe, Tomoyuki; Yamasaki, Takayuki; Suma, Akira; Orita, Takuya et al. (2024). Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety. Bioorganic and Medicinal Chemistry Letters 110, 129864. 10.1016/j.bmcl.2024.129864. [PDB: 8zh4] CMCF-ID Health
Zhu, X.; Moineau, S.; Shi, R. (2025). Crystal structure of the HEPN family member AbiV (P212121 space group). Protein Data Bank: 9bj5. CMCF-BM Agriculture
Tran, T.T.Q.; Pham, N.T.H.; Calmettes, C.; Doucet, N. (2025). Crystal structure of human ribonuclease 7 (RNase 7) in complex with 5'-adenosine monophosphate (5'-AMP). Protein Data Bank: 9csn. CMCF-BM Agriculture
Tran, T.T.Q.; Pham, N.T.H.; Calmettes, C.; Doucet, N. (2025). Crystal structure of human ribonuclease 7 (RNase 7, HsR7). Protein Data Bank: 9csm. CMCF-BM Agriculture
Tran, T.T.Q.; Pham, N.T.H.; Calmettes, C.; Doucet, N. (2024). Crystal structure of a resurrected ancestor (AncRNase) of the pancreatic-type RNases 2 and 3 sub-families. Protein Data Bank: 8g9a. CMCF-BM Agriculture
Sychantha, D.; Prehna, G.; Wright, G.D. (2024). Crystal structure of NikA in complex Ni-AMA. Protein Data Bank: 8spm. CMCF-BM Agriculture
Penner, T.V.; Prehna, G. (2024). Crystal structure of Sel-1 repeat protein LceB from Legionella pneumophila. Protein Data Bank: 8sxq. CMCF-BM Agriculture
Kenward, C.; Mosimann, W.A.; Worrall, L.J.; Strynadka, N.C.J. (2025). Crystal structure of SARS-CoV-2 Mpro Mutant P132H. Protein Data Bank: 9pfi. CMCF-BM Agriculture