Publication Beamlines Strategic Pillar
Smith, Christopher R.; Chen, Dan; Christensen, James G.; Coulombe, René; Féthière, James et al. (2023). Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of Medicinal Chemistry 67(1) , 774-781. 10.1021/acs.jmedchem.3c02140. [PDB: 8t5g, 8t5m, 8t5r] CMCF-BM, CMCF-ID Health
Shurtleff, Valerie W.; Layton, Mark E.; Parish, Craig A.; Perkins, James J.; Schreier, John D. et al. (2024). Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.3c02248. [PDB: 8ute] CMCF-BM Health
Shen, Yao; Gomez-Blanco, Josue; Petassi, Michael T.; Peters, Joseph E.; Ortega, Joaquin et al. (2022). Structural basis for DNA targeting by the Tn7 transposon. Nature Structural and Molecular Biology 29(2) , 143-151. 10.1038/s41594-022-00724-8. [PDB: 7mbw] CMCF-BM Health
Sharon, Itai; Schmeing, T. Martin (2023). Bioinformatics of cyanophycin metabolism genes and characterization of promiscuous isoaspartyl dipeptidases that catalyze the final step of cyanophycin degradation. Scientific Reports 13(1) . 10.1038/s41598-023-34587-w. CMCF-BM Health
Sharon, Itai; McKay, Geoffrey A.; Nguyen, Dao; Schmeing, T. Martin (2023). Discovery of cyanophycin dipeptide hydrolase enzymes suggests widespread utility of the natural biopolymer cyanophycin. Proceedings of the National Academy of Sciences of the United States of America 120(8) . 10.1073/pnas.2216547120. CMCF-BM Health
Sharon, Itai; Grogg, Marcel; Hilvert, Donald; Schmeing, T. Martin (2022). The structure of cyanophycinase in complex with a cyanophycin degradation intermediate. Biochimica et Biophysica Acta - General Subjects 1866(11) , 130217. 10.1016/j.bbagen.2022.130217. [PDB: 7uqv] CMCF-BM Health
Sharon, Itai; Grogg, Marcel; Hilvert, Donald; Schmeing, T. Martin (2022). Structure and Function of the β-Asp-Arg Polymerase Cyanophycin Synthetase 2. ACS Chemical Biology 17(3) . 10.1021/acschembio.1c01007. [PDB: 7ta5] CMCF-BM Health
Satishkumar, Nidhi; Alexander, J Andrew N; Poon, Raymond; Buggeln, Emma; Argudín, Maria A et al. (2021). PBP4-mediated β-lactam resistance among clinical strains of Staphylococcus aureus. Journal of Antimicrobial Chemotherapy 76(9) . 10.1093/jac/dkab201. [PDB: 7kcv] CMCF-BM Health
Saran, Anshu; Kim, Hey-Min; Manning, Ireland; Hancock, Mark A; Schmitz, Claus et al. (2024). Unveiling the molecular mechanisms of the type IX secretion system's response regulator: Structural and functional insights. PNAS Nexus 3(8) . 10.1093/pnasnexus/pgae316. [PDB: 8ted] CMCF-BM Health
Rolando, Monica; Wah Chung, Ivy Yeuk; Xu, Caishuang; Gomez-Valero, Laura; England, Patrick et al. (2023). The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin. mBio 14(5) . 10.1128/mbio.01655-23. [PDB: 8swi] CMCF-BM Health
Radka, Christopher D.; Aller, Stephen G. (2021). Site 2 of the Yersinia pestis substrate-binding protein YfeA is a dynamic surface metal-binding site. Acta Crystallographica Section F:Structural Biology Communications 77(9) , 286-293. 10.1107/s2053230x21008086. [PDB: 7me1] CMCF-BM Health
Pollock, Georgina L.; Grishin, Andrey M.; Giogha, Cristina; Gan, Jiyao; Oates, Clare V. et al. (2022). Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli. Proceedings of the National Academy of Sciences of the United States of America 119(34) . 10.1073/pnas.2204332119. [PDB: 7tzk] CMCF-BM Health
Pham, N. T. Hang; Létourneau, Myriam; Fortier, Marlène; Bégin, Gabriel; Al-Abdul-Wahid, M. Sameer et al. (2021). Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7. Journal of Biological Chemistry 297(5) , 101308. 10.1016/j.jbc.2021.101308. [PDB: 6vtp, 6vtr] CMCF-BM Health
Petraccione, Kaylee; Ali, Mohamed G. H.; Cyr, Normand; Wahba, Haytham M.; Stocker, Timothy et al. (2024). An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy. PLoS Pathogens 20(3) , e1012093. 10.1371/journal.ppat.1012093. [PDB: 8t2m] CMCF-BM Health
Pérez-Vargas, Jimena; Worrall, Liam J.; Olmstead, Andrea D.; Ton, Anh-Tien; Lee, Jaeyong et al. (2023). A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants. Emerging Microbes and Infections 12(2) . 10.1080/22221751.2023.2246594. [PDB: 8cyu, 8cyz, 8sxr] CMCF-BM Health