Publication Beamlines Strategic Pillar
Cottrell, Kevin M.; Briggs, Kimberly J.; Whittington, Douglas A.; Jahic, Haris; Ali, Janid A. et al. (2024). Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers. Journal of Medicinal Chemistry 67(8) , 6064-6080. 10.1021/acs.jmedchem.4c00133. [PDB: 8veu] CMCF-ID Health
Cottrell, Kevin M.; Briggs, Kimberly J.; Tsai, Alice; Tonini, Matthew R.; Whittington, Douglas A. et al. (2025). Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion. Journal of Medicinal Chemistry 68(5) , 5097-5119. 10.1021/acs.jmedchem.4c03067. [PDB: 9n3o] CMCF-BM Health
Cooper, David M.L.; Harrison, Kim D.; Hiebert, Beverly D.; King, Gavin A.; Panahifar, Arash et al. (2023). Daily administration of parathyroid hormone slows the progression of basic multicellular units in the cortical bone of the rabbit distal tibia. Bone 176, 116864. 10.1016/j.bone.2023.116864. BMIT-ID Health
Cook, Jonathan D.; Khondker, Adree; Lee, Jeffrey E. (2022). Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies. Communications Biology 5(1) . 10.1038/s42003-022-03235-w. [PDB: 7n04, 7n05, 7n07, 7n08] CMCF-ID Health
Colussi, Danielle M.; Grainger, Ryan; Noble, Megan; Lake, Taylor; Junop, Murray et al. (2025). Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb. Computational and Structural Biotechnology Journal 27, 190-213. 10.1016/j.csbj.2024.12.007. [PDB: 8urg] CMCF-BM Health
Cole, Andrew G.; Kultgen, Steven G.; Mani, Nagraj; Quintero, Jorge G.; Yi Fan, Kristi et al. (2023). Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506. Bioorganic and Medicinal Chemistry Letters 94, 129456. 10.1016/j.bmcl.2023.129456. [PDB: 8gbu] CMCF-ID Health
Colautti, Jake; Bullen, Nathan P.; Whitney, John C. (2023). Lack of evidence that Pseudomonas aeruginosa AmpDh3‐PA0808 constitute a type VI secretion system effector–immunity pair. Molecular Microbiology . 10.1111/mmi.15021. [PDB: 8es5] CMCF-ID Health
Chung, Ivy Y. W.; Li, Lei; Tyurin, Oleg; Gagarinova, Alla; Wibawa, Raissa et al. (2021). Structural and functional study of Legionella pneumophila effector RavA. Protein Science 30(5) . 10.1002/pro.4057. [PDB: 6wo6] CMCF-ID Health
Chung, Ivy Yeuk Wah; Li, Lei; Cygler, Miroslaw (2021). Legionella effector LegA15/AnkH contains an unrecognized cysteine protease-like domain and displays structural similarity to LegA3/AnkD, but differs in host cell localization. Acta Crystallographica Section D: Structural Biology 77(12) . 10.1107/s2059798321010469. [PDB: 7kj6] CMCF-BM Health
Chung, Ivy Yeuk Wah; Cygler, Miroslaw (2022). Structural study of Legionella pneumophila effector DotY (Lpg0294), a component of the Dot/Icm type IV secretion system. Acta Crystallographica Section F:Structural Biology Communications 78(7) , 276-280. 10.1107/s2053230x22006604. [PDB: 7ups] CMCF-BM Health
Chung, Chun-wa; Dai, Han; Fernandez, Esther; Tinworth, Christopher P.; Churcher, Ian et al. (2020). Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chemical Biology 15(9) . 10.1021/acschembio.0c00266. [PDB: 6zhc] CMCF-ID Health
Chew, Kylie S.; Wells, Robert C.; Moshkforoush, Arash; Chan, Darren; Lechtenberg, Kendra J. et al. (2023). CD98hc is a target for brain delivery of biotherapeutics. Nature Communications 14(1) . 10.1038/s41467-023-40681-4. [PDB: 8g0m] CMCF-ID Health
Chen, Yu Seby; Kozlov, Guennadi; Moeller, Brandon E.; Rohaim, Ahmed; Fakih, Rayan et al. (2021). Crystal structure of an archaeal CorB magnesium transporter. Nature Communications 12(1) . 10.1038/s41467-021-24282-7. [PDB: 7m1t, 7m1u] CMCF-ID Health
Chen, Yu Seby; Kozlov, Guennadi; Fakih, Rayan; Yang, Meng; Zhang, Zhidian et al. (2020). Mg2+-ATP Sensing in CNNM, a Putative Magnesium Transporter. Structure 28(3) . 10.1016/j.str.2019.11.016. [PDB: 6n7e] CMCF-ID Health
Chen, Yinshan; Baviriseaty, Sruthika; Thool, Prajwal; Gautreau, Jonah; Yawman, Phillip D. et al. (2025). Quantitative Structural and Compositional Elucidation of Real-World Pharmaceutical Tablet Using Large Field-of-View, Correlative Microscopy-Tomography Techniques and AI-Enabled Image Analysis. Pharmaceutical Research 42(1) , 203-217. 10.1007/s11095-024-03812-0. BMIT-BM Health