Publication Beamlines Strategic Pillar
Huhn, Annissa J.; Gardberg, Anna S.; Poy, Florence; Brucelle, Francois; Vivat, Valerie et al. (2020). Early Drug‐Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors. ChemMedChem 15(11) . 10.1002/cmdc.202000007. [PDB: 6v8n] CMCF-ID Health
Mitcheltree, Matthew J.; Li, Derun; Achab, Abdelghani; Beard, Adam; Chakravarthy, Kalyan et al. (2020). Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy. ACS Medicinal Chemistry Letters 11(4) , 582-588. 10.1021/acsmedchemlett.0c00058. [PDB: 6v7c] CMCF-ID Health
Manenda, Mahder S.; Picard, Marie-Ève; Zhang, Liping; Cyr, Normand; Zhu, Xiaojun et al. (2020). Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations. Journal of Biological Chemistry 295(14) , jbc.RA119.011212. 10.1074/jbc.ra119.011212. [PDB: 6u0p, 6u0s] CMCF-ID Health
Mendoza, Matthew N.; Jian, Mike; King, Moeko T.; Brooks, Cory L. (2020). Role of a noncanonical disulfide bond in the stability, affinity, and flexibility of a VHH specific for the Listeria virulence factor InlB. Protein Science 29(4) , 1004-1017. 10.1002/pro.3831. [PDB: 6u12, 6u14] CMCF-ID Health
Li, Franco K.K.; Rosell, Federico I.; Gale, Robert T.; Simorre, Jean-Pierre; Brown, Eric D. et al. (2020). Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase. Journal of Biological Chemistry 295(9) , 2629-2639. 10.1074/jbc.ra119.011469. [PDB: 6uex, 6uf3, 6uf5, 6uf6] CMCF-ID Health
Alonzo, Diego A.; Chiche-Lapierre, Clarisse; Tarry, Michael J.; Wang, Jimin; Schmeing, T. Martin et al. (2020). Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis. Nature Chemical Biology 16(5) . 10.1038/s41589-020-0481-5. [PDB: 6ulz] CMCF-ID Health
Majdi Yazdi, Mohadeseh; Saran, Sagar; Mrozowich, Tyler; Lehnert, Cheyanne; Patel, Trushar R. et al. (2020). Asparagine-84, a regulatory allosteric site residue, helps maintain the quaternary structure of Campylobacter jejuni dihydrodipicolinate synthase. Journal of Structural Biology 209(1) . 10.1016/j.jsb.2019.107409. [PDB: 6tzu, 6u01] CMCF-BM, CMCF-ID Health
Mascle, Xavier H.; Gagnon, Christina; Wahba, Haytham M.; Lussier-Price, Mathieu; Cappadocia, Laurent et al. (2020). Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure 28(2) . 10.1016/j.str.2019.11.019. [PDB: 6uyo, 6uyp, 6uyq, 6uyr, 6uyu, 6uyz] CMCF-ID Health
Petrilli, Whitney L.; Adam, Gregory C.; Erdmann, Roman S.; Abeywickrema, Pravien; Agnani, Vijayalakshmi et al. (2020). From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chemical Biology 27(1) , 32-40. 10.1016/j.chembiol.2019.10.002. [PDB: 6u36] CMCF-ID Health
Chen, Yu Seby; Kozlov, Guennadi; Fakih, Rayan; Yang, Meng; Zhang, Zhidian et al. (2020). Mg2+-ATP Sensing in CNNM, a Putative Magnesium Transporter. Structure 28(3) . 10.1016/j.str.2019.11.016. [PDB: 6n7e] CMCF-ID Health
Gagarina, Varvara; Bojagora, Anna; Lacdao, Ira Kay; Luthra, Niharika; Pfoh, Roland et al. (2020). Structural Basis of the Interaction Between Ubiquitin Specific Protease 7 and Enhancer of Zeste Homolog 2. Journal of Molecular Biology 432(4) . 10.1016/j.jmb.2019.12.026. [PDB: 6p5l] CMCF-ID Health
Geiger, Michael; Brown, Chris; Wichers, Jan Stephan; Strauss, Jan; Lill, Andrés et al. (2020). Structural Insights Into PfARO and Characterization of its Interaction With PfAIP. Journal of Molecular Biology 432(4) . 10.1016/j.jmb.2019.12.024. CMCF-ID Health
Sokaribo, Akosiererem; Novakovski, Brian A.A.; Cotelesage, Julien; White, Aaron P.; Sanders, David et al. (2020). Kinetic and structural analysis of Escherichia coli phosphoenolpyruvate carboxykinase mutants. Biochimica et Biophysica Acta - General Subjects 1864(4) , 129517. 10.1016/j.bbagen.2020.129517. [PDB: 6v2l, 6v2m, 6v2n] CMCF-BM, CMCF-ID Health
Chatterjee, Som; Poon, Raymond; Satishkumar, Nidhi; Mosimann, Wesley; Hayatnagarkar, Vedangi et al. (2026). Stk1 is required for BlaR1-mediated broad-spectrum β-lactam resistance in epidemic-causing strains of Staphylococcus aureus. Materials & Design . 10.21203/rs.3.rs-8331258/v1. [PDB: 9ymt] CMCF-BM Agriculture
Merchant, Rohan R.; Chernyak, Natalia; Lopez, Jovan A.; Sharp, Phillip P.; Mandal, Mihir et al. (2026). N -Alkyl and N -Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors. ACS Medicinal Chemistry Letters 17(3) , 744-749. 10.1021/acsmedchemlett.6c00066. [PDB: 10qs] CMCF-BM Agriculture