Publication Beamlines Strategic Pillar
Caveney, Nathanael A.; Caballero, Guillermo; Voedts, Henri; Niciforovic, Ana; Worrall, Liam J. et al. (2019). Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli. Nature Communications 10(1) . 10.1038/s41467-019-09507-0. [PDB: 6ntz] CMCF-BM, CMCF-ID Health
Almawi, Ahmad W; Scotland, Michelle K; Randall, Justin R; Liu, Linda; Martin, Heather K et al. (2019). Binding of the regulatory domain of MutL to the sliding β-clamp is species specific. Nucleic Acids Research 47(9) . 10.1093/nar/gkz115. [PDB: 6e8d, 6e8e] CMCF-BM, CMCF-ID Health
Sengupta, Shomit; Giaime, Emilie; Narayan, Sridhar; Hahm, Seung; Howell, Jessica et al. (2019). Discovery of NV-5138, the first selective Brain mTORC1 activator. Scientific Reports 9(1) , 4107. 10.1038/s41598-019-40693-5. [PDB: 6n0m] CMCF-ID Health
Simonetta, Kyle R.; Taygerly, Joshua; Boyle, Kathleen; Basham, Stephen E.; Padovani, Chris et al. (2019). Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications 10(1) , 1402. 10.1038/s41467-019-09358-9. [PDB: 6m91, 6m92, 6m93, 6m94] CMCF-ID Health
Raman, Swetha; Beilschmidt, Melissa; To, Minh; Lin, Kevin; Lui, Francine et al. (2019). Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proceedings of the National Academy of Sciences of the United States of America 116(14) , 6812-6817. 10.1073/pnas.1817246116. [PDB: 6o39, 6o3a] CMCF-ID Health
Li, Tang; Stephen, Preyesh; Zhu, Dao‐Wei; Shi, Rong; Lin, Sheng‐Xiang et al. (2019). Crystal structures of human 17β‐hydroxysteroid dehydrogenase type 1 complexed with estrone andNADP+reveal the mechanism of substrate inhibition. FEBS Journal 286(11) . 10.1111/febs.14784. [PDB: 6mne] CMCF-BM, CMCF-ID Health
Mangat, Chand S.; Vadlamani, Grishma; Holicek, Viktor; Chu, Mitchell; Larmour, Veronica L. C. et al. (2019). Molecular Basis for the Potent Inhibition of the Emerging Carbapenemase VCC-1 by Avibactam. Antimicrobial Agents and Chemotherapy 63(4) . 10.1128/aac.02112-18. [PDB: 6mk6] CMCF-BM, CMCF-ID Health
Zhang, Birong; Kiefer, James R.; Blake, Robert A.; Chang, Jae H.; Hartman, Steven et al. (2019). Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorganic and Medicinal Chemistry Letters 29(7) . 10.1016/j.bmcl.2019.01.036. [PDB: 6dfn] CMCF-ID Health
Wei, Yong; Xiong, Zi Jian; Li, Jun; Zou, Chunxia; Cairo, Christopher W. et al. (2019). Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters. Communications Biology 2(1) . 10.1038/s42003-018-0262-9. [PDB: 6e7o] CMCF-ID Health
Whitesell, Luke; Robbins, Nicole; Huang, David S.; McLellan, Catherine A.; Shekhar-Guturja, Tanvi et al. (2019). Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications 10(1) , 402. 10.1038/s41467-018-08248-w. [PDB: 6cjl, 6cjp] CMCF-ID Health
Gytz, Heidi; Liang, Jason; Liang, Yingke; Gorelik, Alexei; Illes, Katalin et al. (2019). The structure of mammalian β‐mannosidase provides insight into β‐mannosidosis and nystagmus. FEBS Journal 286(7) . 10.1111/febs.14731. [PDB: 6ddt, 6ddu] CMCF-ID Health
Ryan, Patrick; Forrester, Taylor J.B.; Wroblewski, Charles; Kenney, Tristan M.G.; Kitova, Elena N. et al. (2019). The small RbcS-like domains of the β-carboxysome structural protein CcmM bind RubisCO at a site distinct from that binding the RbcS subunit. Journal of Biological Chemistry 294(8) , 2593-2603. 10.1074/jbc.ra118.006330. [PDB: 6mr1] CMCF-ID Health
Vara, Brandon A.; Lim, Jongwon; Moure, Casey J.; Schneider, Sebastian E.; Yeung, Charles S. et al. (2026). Discovery and In Vivo Evaluation of Aryl Ether YAP1/TEAD Inhibitors for the Treatment of Hippo-Driven Malignancies. Journal of Medicinal Chemistry 69(4) , 4303-4316. 10.1021/acs.jmedchem.5c02997. [PDB: 9yk2] CMCF-BM Health
Pham, N. T. Hang; Paré, Alex; Létourneau, Myriam; Fortier, Marlène; Chatenet, David et al. (2026). Network‐based allosteric analysis of galectin‐7: Key residues dictate functional communication and stability. Protein Science 35(3) . 10.1002/pro.70502. [PDB: 7n4o, 7n6c, 7n96] CMCF-BM Health
Van Schepdael, Matthew; Asakereh, Iman; Colautti, Jake; Gierys, Andrew J.; Sachar, Kartik et al. (2026). Biophysical characterization of Eag chaperones suggests the mechanism of effector transmembrane domain release. Nature Communications . 10.1038/s41467-025-68138-w. [PDB: 9mvg] CMCF-BM Health