Publication Beamlines Strategic Pillar
Cregg, James; Pota, Kristof; Tomlinson, Aidan C. A.; Yano, Jason; Marquez, Abby et al. (2025). Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02313. [PDB: 9bfv, 9bfw] CMCF-ID Health
Cummer, Rebecca; Grosjean, Félix; Bolteau, Raphaël; Vasegh, Seyed Ehsan; Veyron, Simon et al. (2024). Structure-activity relationship of inositol thiophosphate analogs as allosteric activators of Clostridioides difficile toxin B. Applied Spectroscopy Reviews . 10.26434/chemrxiv-2024-2cf6g-v2. [PDB: 9bja] CMCF-ID Health
Curtin, Michael L.; Pliushchev, Marina A.; Li, Huan-Qiu; Torrent, Maricel; Dietrich, Justin D. et al. (2017). SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorganic and Medicinal Chemistry Letters 27(7) , 1576-1583. 10.1016/j.bmcl.2017.02.030. [PDB: 5u69, 5u6d] CMCF-ID Health
Cyr, Patrick; Fader, Lee D.; Burch, Jason D.; Pike, Kelly A.; Sietsema, Daniel V. et al. (2024). Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization. ACS Medicinal Chemistry Letters 15(12) , 2201-2209. 10.1021/acsmedchemlett.4c00471. [PDB: 9mdc] CMCF-ID Health
Daniel-Ivad, Phillip; Ryan, Katherine S. (2024). An imine reductase that captures reactive intermediates in the biosynthesis of the indolocarbazole reductasporine. Journal of Biological Chemistry , 105642. 10.1016/j.jbc.2024.105642. CMCF-ID Health
Das, Samir; Gilchrist, John; Bosmans, Frank; Van Petegem, Filip (2016). Binary architecture of the Nav1.2-β2 signaling complex. eLife 5, e10960. 10.7554/elife.10960. [PDB: 5feb] CMCF-ID Health
Davies, Christopher W.; Stowe, Irma; Phung, Qui T.; Ho, Hoangdung; Bakalarski, Corey E. et al. (2021). Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function. Proceedings of the National Academy of Sciences of the United States of America 118(12) , e2018024118. 10.1073/pnas.2018024118. [PDB: 7jwq] CMCF-ID Health
Dementiev, Alexey; Silva, Abel; Yee, Calvin; Li, Zhe; Flavin, Michael T. et al. (2018). Structures of human plasma β–factor XIIa cocrystallized with potent inhibitors. Blood Advances 2(5) , 549-558. 10.1182/bloodadvances.2018016337. [PDB: 6b74] CMCF-ID Health
Després, Philippe C.; Dubé, Alexandre K.; Picard, Marie-Ève; Grenier, Jordan; Shi, Rong et al. (2024). Compensatory mutations potentiate constructive neutral evolution by gene duplication. Science 385(6710) , 770-775. 10.1126/science.ado5719. [PDB: 8vll, 8vlm] CMCF-BM, CMCF-ID Health
Dong, Cheng; Chen, Shun-Jia; Melnykov, Artem; Weirich, Sara; Sun, Kelly et al. (2020). Recognition of nonproline N-terminal residues by the Pro/N-degron pathway. Proceedings of the National Academy of Sciences of the United States of America 117(25) , 14158-14167. 10.1073/pnas.2007085117. [PDB: 6wzz] CMCF-ID Health
Dong, Cheng; Dong, Guangping; Li, Li; Zhu, Licheng; Tempel, Wolfram et al. (2018). An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2. Communications Biology 1(1) . 10.1038/s42003-018-0196-2. [PDB: 6dub] CMCF-ID Health
Dong, Cheng; Nakagawa, Reiko; Oyama, Kyohei; Yamamoto, Yusuke; Zhang, Weilian et al. (2020). Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. eLife 9. 10.7554/elife.58675. [PDB: 6wat, 6wau] CMCF-BM, CMCF-ID Health
Dong, Cheng; Zhang, Heng; Li, Li; Tempel, Wolfram; Loppnau, Peter et al. (2018). Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Nature Chemical Biology 14(5) , 466-473. 10.1038/s41589-018-0036-1. [PDB: 6cdc] CMCF-ID Health
Doyle, Liam; Ovchinnikova, Olga G.; Huang, Bo-Shun; Forrester, Taylor J.B.; Lowary, Todd L. et al. (2023). Mechanism and linkage specificities of the dual retaining β-Kdo glycosyltransferase modules of KpsC from bacterial capsule biosynthesis. Journal of Biological Chemistry , 104609. 10.1016/j.jbc.2023.104609. [PDB: 8fuw, 8fux] CMCF-ID Health
Doyle, Liam; Ovchinnikova, Olga G.; Myler, Katharine; Mallette, Evan; Huang, Bo-Shun et al. (2019). Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules. Nature Chemical Biology 15(6) . 10.1038/s41589-019-0276-8. [PDB: 6mgb, 6mgc, 6mgd] CMCF-BM, CMCF-ID Health