Publication Beamlines Strategic Pillar
Cregg, James; Edwards, Anne V.; Chang, Stephanie; Lee, Bianca J.; Knox, John E. et al. (2025). Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02314. [PDB: 9bg0, 9bg2, 9bg3, 9bg4, 9bg5, 9bg6, 9bg8, 9bga, 9bgb, 9bgc, 9bgd] CMCF-ID Health
Crawford, Terry D.; Tsui, Vickie; Flynn, E. Megan; Wang, Shumei; Taylor, Alexander M. et al. (2016). Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. Journal of Medicinal Chemistry 59(11) , 5391-5402. 10.1021/acs.jmedchem.6b00264. [PDB: 5i29] CMCF-ID Health
Crawford, Terry D.; Romero, F. Anthony; Lai, Kwong Wah; Tsui, Vickie; Taylor, Alexander M. et al. (2016). Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. Journal of Medicinal Chemistry 59(23) , 10549-10563. 10.1021/acs.jmedchem.6b01022. [PDB: 5ktw] CMCF-ID Health
Crawford, Terry D.; Audia, James E.; Bellon, Steve; Burdick, Daniel J.; Bommi-Reddy, Archana et al. (2017). GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). ACS Medicinal Chemistry Letters 8(7) , 737-741. 10.1021/acsmedchemlett.7b00132. [PDB: 5v84] CMCF-ID Health
Cranston, Rosemary R.; Vebber, Mário C.; Faleiro Berbigier, Jônatas; Brusso, Jaclyn; Kelly, Timothy L. et al. (2022). High Performance Solution Processed n‐Type OTFTs through Surface Engineered F–F Interactions Using Asymmetric Silicon Phthalocyanines. Advanced Electronic Materials , 2200696. 10.1002/aelm.202200696. BXDS-WLE Materials
Cranston, Rosemary R.; Vebber, Mário C.; Berbigier, Jônatas Faleiro; Rice, Nicole A.; Tonnelé, Claire et al. (2020). Thin-Film Engineering of Solution-Processable n-Type Silicon Phthalocyanines for Organic Thin-Film Transistors. ACS Applied Materials and Interfaces 13(1) , 1008-1020. 10.1021/acsami.0c17657. HXMA Materials
Coutant, Maxime; Lepot, Kevin; Fadel, Alexandre; Addad, Ahmed; Richard, Elodie et al. (2022). Distinguishing cellular from abiotic spheroidal microstructures in the ca. 3.4 Ga Strelley Pool Formation. Geobiology 20(5) , 599-622. 10.1111/gbi.12506. SM Environment
Courchesne, Brittaney; Schindler, Michael; Mykytczuk, Nadia C. S. (2021). Relationships Between the Microbial Composition and the Geochemistry and Mineralogy of the Cobalt-Bearing Legacy Mine Tailings in Northeastern Ontario. Frontiers in Microbiology 12. 10.3389/fmicb.2021.660190. VESPERS Environment
Cottrell, Kevin M.; Briggs, Kimberly J.; Whittington, Douglas A.; Jahic, Haris; Ali, Janid A. et al. (2024). Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers. Journal of Medicinal Chemistry 67(8) , 6064-6080. 10.1021/acs.jmedchem.4c00133. [PDB: 8veu] CMCF-ID Health
Cottrell, Kevin M.; Briggs, Kimberly J.; Tsai, Alice; Tonini, Matthew R.; Whittington, Douglas A. et al. (2025). Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion. Journal of Medicinal Chemistry 68(5) , 5097-5119. 10.1021/acs.jmedchem.4c03067. [PDB: 9n3o] CMCF-BM Health