Publication Beamlines Strategic Pillar
Kwan, David H.; Constantinescu, Iren; Chapanian, Rafi; Higgins, Melanie A.; Kötzler, Miriam P et al. (2015). Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution. Journal of the American Chemical Society 137(17) , 5695-5705. 10.1021/ja5116088. [PDB: 4d6c, 4d6d, 4d6e, 4d6g] CMCF-BM, CMCF-ID Health
Kwan, David H.; Constantinescu, Iren; Chapanian, Rafi; Higgins, Melanie A.; Kötzler, Miriam P et al. (2015). Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution. Journal of the American Chemical Society 137(17) , 5695-5705. 10.1021/ja5116088. [PDB: 4d6c, 4d6d, 4d6e, 4d6g] CMCF-BM, CMCF-ID Health
Kwon, Min Chul; Thuring, Jan Willem; Querolle, Olivier; Dai, Xuedong; Verhulst, Tinne et al. (2024). Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias. Blood 144(11) , 1206-1220. 10.1182/blood.2023022480. [PDB: 9z4x] CMCF-ID Health
Labandera, Anne-Marie; Uhrig, R. Glen; Colville, Keaton; Moorhead, Greg B.; Ng, Kenneth K. S. et al. (2018). Structural basis for the preference of the Arabidopsis thaliana phosphatase RLPH2 for tyrosine-phosphorylated substrates. Science Signaling 11(524) , eaan8804. 10.1126/scisignal.aan8804. [PDB: 5vjv, 5vjw] CMCF-BM Health
Labiuk, Shaunivan L.; Sygusch, Jurgen; Grochulski, Pawel (2019). Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan. Acta Crystallographica Section F:Structural Biology Communications 75(6) , 405-411. 10.1107/s2053230x19006046. Health
Labriola, Jonathan M.; Zhou, Yifan; Nagar, Bhushan (2018). Structural Analysis of the Bacterial Effector AvrA Identifies a Critical Helix Involved in Substrate Recognition. Biochemistry 57(33) , 4985-4996. 10.1021/acs.biochem.8b00512. [PDB: 6be0] CMCF-ID Health
Lacbay, Cyrus M.; Waller, Daniel D.; Park, Jaeok; Gómez Palou, Mònica; Vincent, Félix et al. (2018). Unraveling the Prenylation–Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. Journal of Medicinal Chemistry 61(15) , 6904-6917. 10.1021/acs.jmedchem.8b00886. [PDB: 6c56, 6c57] CMCF-ID Health
Lang, Dean E.; Morris, Jeremy S.; Rowley, Michael; Torres, Miguel A.; Maksimovich, Vook A. et al. (2019). Structure–function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition. Journal of Biological Chemistry 294(40) , jbc.RA119.009214. 10.1074/jbc.ra119.009214. [PDB: 6p3m] CMCF-BM Health
Langelaan, David N.; Liburd, Janine; Yang, Yidai; Miller, Emily; Chitayat, Seth et al. (2016). Structure of the Single-lobe Myosin Light Chain C in Complex with the Light Chain-binding Domains of Myosin-1C Provides Insights into Divergent IQ Motif Recognition. Journal of Biological Chemistry 291(37) , 19607-19617. 10.1074/jbc.m116.746313. [PDB: 5ibw] CMCF-ID Health
Langelier, Marie-France; Mirhasan, Manija; Gilbert, Karine; Sverzhinksy, Aleksandr; Furtos, Alexandra et al. (2024). PARP enzyme de novo synthesis of protein-free poly(ADP-ribose). Molecular Cell 84(24) , 4758-4773.e6. 10.1016/j.molcel.2024.10.024. [PDB: 9bpy, 9dmc] CMCF-BM Health
Lang, Shenhui; Cressatti, Marisa; Mendoza, Kris E.; Coumoundouros, Chelsea N.; Plater, Samantha M. et al. (2015). YehZYXW of Escherichia coli Is a Low-Affinity, Non-Osmoregulatory Betaine-Specific ABC Transporter. Biochemistry 54(37) , 5735-5747. 10.1021/acs.biochem.5b00274. [PDB: 4wep] CMCF-ID Health
Langston, Steven P.; Grossman, Stephen; England, Dylan; Afroze, Roushan; Bence, Neil et al. (2021). Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. Journal of Medicinal Chemistry 64(5) . 10.1021/acs.jmedchem.0c01491. [PDB: 6xog, 6xoh] CMCF-ID Health
Lee, Eunjeong; Redzic, Jasmina S.; Gordon, Blaine; Saviola, Anthony J.; Tran, Norman et al. (2025). Streptococcus pneumoniae HtrA is a dynamic and monomeric virulence factor capable of forming larger oligomeric complexes. Protein Science 35(1) . 10.1002/pro.70411. [PDB: 9pno] CMCF-BM Health
Lee, Eunjeong; Tran, Norman; Redzic, Jasmina S.; Singh, Harmanpreet; Alamillo, Lorena et al. (2025). Identifying and controlling inactive and active conformations of a serine protease. Science Advances 11(15) . 10.1126/sciadv.adu7447. [PDB: 9bsh, 9bsm] CMCF-BM Health
Lee, Jaeyong; Kenward, Calem; Worrall, Liam J.; Vuckovic, Marija; Gentile, Francesco et al. (2022). X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation. Nature Communications 13(1) . 10.1038/s41467-022-32854-4. [PDB: 8dru, 8drx, 8ds1] CMCF-BM Health