Publication Beamlines Strategic Pillar
Coquelle, Nicolas; Havali-Shahriari, Zahra; Bernstein, Nina; Green, Ruth; Glover, J. N. Mark et al. (2011). Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates. Proceedings of the National Academy of Sciences of the United States of America 108(52) , 21022-21027. 10.1073/pnas.1112036108. CMCF-ID Health
Cregg, James; Edwards, Anne V.; Chang, Stephanie; Lee, Bianca J.; Knox, John E. et al. (2025). Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02314. CMCF-ID Health
Cregg, James; Pota, Kristof; Tomlinson, Aidan C. A.; Yano, Jason; Marquez, Abby et al. (2025). Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02313. CMCF-ID Health
Crowe, Adam M.; Workman, Sean D.; Watanabe, Nobuhiko; Worrall, Liam J.; Strynadka, Natalie C. J. et al. (2018). IpdAB, a virulence factor in Mycobacterium tuberculosis , is a cholesterol ring-cleaving hydrolase. Proceedings of the National Academy of Sciences of the United States of America 115(15) , E3378-E3387. 10.1073/pnas.1717015115. CMCF-BM Health
Curtin, Michael L.; Pliushchev, Marina A.; Li, Huan-Qiu; Torrent, Maricel; Dietrich, Justin D. et al. (2017). SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorganic and Medicinal Chemistry Letters 27(7) , 1576-1583. 10.1016/j.bmcl.2017.02.030. CMCF-ID Health
Cuskin, Fiona; Lowe, Elisabeth C.; Temple, Max J.; Zhu, Yanping; Cameron, Elizabeth A. et al. (2015). Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism. Nature 517(7533) , 165-169. 10.1038/nature13995. CMCF-BM, CMCF-ID Health
Cuskin, Fiona; Lowe, Elisabeth C.; Temple, Max J.; Zhu, Yanping; Cameron, Elizabeth A. et al. (2015). Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism. Nature 517(7533) , 165-169. 10.1038/nature13995. CMCF-BM, CMCF-ID Health
De Schutter, Joris W.; Park, Jaeok; Leung, Chun Yuen; Gormley, Patrick; Lin, Yih-Shyan et al. (2014). Multistage Screening Reveals Chameleon Ligands of the Human Farnesyl Pyrophosphate Synthase: Implications to Drug Discovery for Neurodegenerative Diseases. Journal of Medicinal Chemistry 57(13) , 5764-5776. 10.1021/jm500629e. CMCF-ID Health
Després, Philippe C.; Dubé, Alexandre K.; Picard, Marie-Ève; Grenier, Jordan; Shi, Rong et al. (2024). Compensatory mutations potentiate constructive neutral evolution by gene duplication. Science 385(6710) , 770-775. 10.1126/science.ado5719. CMCF-BM, CMCF-ID Health
Després, Philippe C.; Dubé, Alexandre K.; Picard, Marie-Ève; Grenier, Jordan; Shi, Rong et al. (2024). Compensatory mutations potentiate constructive neutral evolution by gene duplication. Science 385(6710) , 770-775. 10.1126/science.ado5719. CMCF-BM, CMCF-ID Health
Dong, Cheng; Nakagawa, Reiko; Oyama, Kyohei; Yamamoto, Yusuke; Zhang, Weilian et al. (2020). Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. eLife 9. 10.7554/elife.58675. CMCF-BM, CMCF-ID Health
Dong, Cheng; Nakagawa, Reiko; Oyama, Kyohei; Yamamoto, Yusuke; Zhang, Weilian et al. (2020). Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. eLife 9. 10.7554/elife.58675. CMCF-BM, CMCF-ID Health
Doyle, Liam; Ovchinnikova, Olga G.; Huang, Bo-Shun; Forrester, Taylor J.B.; Lowary, Todd L. et al. (2023). Mechanism and linkage specificities of the dual retaining β-Kdo glycosyltransferase modules of KpsC from bacterial capsule biosynthesis. Journal of Biological Chemistry , 104609. 10.1016/j.jbc.2023.104609. CMCF-ID Health
Doyle, Liam; Ovchinnikova, Olga G.; Myler, Katharine; Mallette, Evan; Huang, Bo-Shun et al. (2019). Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules. Nature Chemical Biology 15(6) . 10.1038/s41589-019-0276-8. CMCF-BM, CMCF-ID Health
Doyle, Liam; Ovchinnikova, Olga G.; Myler, Katharine; Mallette, Evan; Huang, Bo-Shun et al. (2019). Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules. Nature Chemical Biology 15(6) . 10.1038/s41589-019-0276-8. CMCF-BM, CMCF-ID Health