Publication Beamlines Strategic Pillar
Kallander, Lara S.; Washburn, David; Hilfiker, Mark A.; Eidam, Hilary Schenck; Lawhorn, Brian G. et al. (2018). Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1. ACS Medicinal Chemistry Letters 9(7) , 736-740. 10.1021/acsmedchemlett.8b00173. [PDB: 6bsm] CMCF-ID Health
Labriola, Jonathan M.; Zhou, Yifan; Nagar, Bhushan (2018). Structural Analysis of the Bacterial Effector AvrA Identifies a Critical Helix Involved in Substrate Recognition. Biochemistry 57(33) , 4985-4996. 10.1021/acs.biochem.8b00512. [PDB: 6be0] CMCF-ID Health
Beyrakhova, Ksenia; Li, Lei; Xu, Caishuang; Gagarinova, Alla; Cygler, Miroslaw et al. (2018). Legionella pneumophila effector Lem4 is a membrane-associated protein tyrosine phosphatase. Journal of Biological Chemistry 293(34) , 13044-13058. 10.1074/jbc.ra118.003845. [PDB: 6cdw, 6cgj] CMCF-ID Health
King, Moeko Toride; Huh, Ian; Shenai, Akhilesh; Brooks, Teresa M.; Brooks, Cory L. et al. (2018). Structural basis of VHH-mediated neutralization of the food-borne pathogen Listeria monocytogenes. Journal of Biological Chemistry 293(35) , 13626-13635. 10.1074/jbc.ra118.003888. [PDB: 6dba, 6dbd, 6dbe, 6dbf, 6dbg] CMCF-ID Health
Sauvé, Véronique; Sung, George; Soya, Naoto; Kozlov, Guennadi; Blaimschein, Nina et al. (2018). Mechanism of parkin activation by phosphorylation. Nature Structural and Molecular Biology 25(7) , 623-630. 10.1038/s41594-018-0088-7. [PDB: 6djw, 6djx] CMCF-ID Health
Bagal, Sharan K.; Andrews, Mark; Bechle, Bruce M.; Bian, Jianwei; Bilsland, James et al. (2018). Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. Journal of Medicinal Chemistry 61(15) , 6779-6800. 10.1021/acs.jmedchem.8b00633. [PDB: 6dkb] CMCF-ID Health
Loewen, Peter C.; De Silva, P. Malaka; Donald, Lynda J.; Switala, Jacek; Villanueva, Jacylyn et al. (2018). KatG-Mediated Oxidation Leading to Reduced Susceptibility of Bacteria to Kanamycin. ACS Omega 3(4) , 4213-4219. 10.1021/acsomega.8b00356. [PDB: 6b9b] CMCF-ID Health
Qiu, Luping; Levine, Kymberly; Gajiwala, Ketan S.; Cronin, Ciarán N.; Nagata, Asako et al. (2018). Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers. PLoS ONE 13(6) , e0198374. 10.1371/journal.pone.0198374. [PDB: 6cz2, 6cz3] CMCF-ID Health
Imkeller, Katharina; Scally, Stephen W.; Bosch, Alexandre; Martí, Gemma Pidelaserra; Costa, Giulia et al. (2018). Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. Science 360(6395) , 1358-1362. 10.1126/science.aar5304. [PDB: 6d01, 6d11] CMCF-ID Health
Gorelik, Alexei; Randriamihaja, Antsa; Illes, Katalin; Nagar, Bhushan (2018). Structural basis for nucleotide recognition by the ectoenzyme CD 203c. FEBS Journal 285(13) . 10.1111/febs.14489. [PDB: 6c01, 6c02] CMCF-ID Health
Mallette, Evan; Kimber, Matthew S. (2018). Structure and Kinetics of the S-(+)-1-Amino-2-propanol Dehydrogenase from the RMM Microcompartment of Mycobacterium smegmatis. Biochemistry 57(26) , 3780-3789. 10.1021/acs.biochem.8b00464. [PDB: 6ci8, 6ci9] CMCF-ID Health
Stöppler, Daniel; Macpherson, Alex; Smith-Penzel, Susanne; Basse, Nicolas; Lecomte, Fabien et al. (2018). Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR. PLoS Biology 16(5) , e2006192. 10.1371/journal.pbio.2006192. [PDB: 6c97, 6c98] CMCF-ID Health
Mellor, Paul; Marshall, Jeremy D. S.; Ruan, Xuan; Whitecross, Dielle E.; Ross, Rebecca L. et al. (2018). Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation. Scientific Reports 8(1) . 10.1038/s41598-018-25487-5. [PDB: 6d81, 6d82, 6d85, 6d86, 6d87] CMCF-BM, CMCF-ID Health
Bonday, Zahid Q.; Cortez, Guillermo S.; Grogan, Michael J.; Antonysamy, Stephen; Weichert, Ken et al. (2018). LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Medicinal Chemistry Letters 9(7) , 612-617. 10.1021/acsmedchemlett.8b00014. [PDB: 6ckc] CMCF-ID Health
Huang, Christine S.; Oberbeck, Nina; Hsiao, Yi-Chun; Liu, Peter; Johnson, Adam R. et al. (2018). Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity. Structure 26(5) , 767-777.e5. 10.1016/j.str.2018.04.002. [PDB: 5wni] CMCF-ID Health