Publication Beamlines Strategic Pillar
D’Costa, Vanessa M.; Braun, Virginie; Landekic, Marija; Shi, Rong; Proteau, Ariane et al. (2015). Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7. Cell Reports 12(9) , 1508-1518. 10.1016/j.celrep.2015.07.063. [PDB: 5cq9] CMCF-ID Health
Wan, Honghe; Schroeder, Gretchen M.; Hart, Amy C.; Inghrim, Jennifer; Grebinski, James et al. (2015). Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms. ACS Medicinal Chemistry Letters 6(8) , 850-855. 10.1021/acsmedchemlett.5b00226. [PDB: 5cf8] CMCF-ID Health
Farha, Maya A.; Czarny, Tomasz L.; Myers, Cullen L.; Worrall, Liam J.; French, Shawn et al. (2015). Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase. Proceedings of the National Academy of Sciences of the United States of America 112(35) , 11048-11053. 10.1073/pnas.1511751112. [PDB: 5cqb, 5cqj] CMCF-ID Health
Piper, Derek E.; Romanow, William G.; Gunawardane, Ruwanthi N.; Fordstrom, Preston; Masterman, Stephanie et al. (2015). The high-resolution crystal structure of human LCAT. Journal of Lipid Research 56(9) , 1711-1719. 10.1194/jlr.m059873. [PDB: 4xwg] CMCF-ID Health
Julien, Jean-Philippe; Cupo, Albert; Sok, Devin; Stanfield, Robyn L.; Lyumkis, Dmitry et al. (2013). Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer. Science 342(6165) , 1477-1483. 10.1126/science.1245625. CMCF-BM, CMCF-ID Health
Sit, Brandon; Crowley, Shauna M.; Bhullar, Kirandeep; Lai, Christine Chieh-Lin; Tang, Calvin et al. (2015). Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen. PLoS Pathogens 11(8) , e1005107. 10.1371/journal.ppat.1005107. [PDB: 4r72, 4r73] CMCF-ID Health
Calmettes, Charles; Ing, Christopher; Buckwalter, Carolyn M.; El Bakkouri, Majida; Chieh-Lin Lai, Christine et al. (2015). The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD. Nature Communications 6(1) . 10.1038/ncomms8996. [PDB: 4rdr, 4rvw] CMCF-ID Health
Little, Dustin J.; Milek, Sonja; Bamford, Natalie C.; Ganguly, Tridib; DiFrancesco, Benjamin R. et al. (2015). The Protein BpsB Is a Poly-β-1,6-N-acetyl-d-glucosamine Deacetylase Required for Biofilm Formation in Bordetella bronchiseptica. Journal of Biological Chemistry 290(37) , 22827-22840. 10.1074/jbc.m115.672469. [PDB: 5bu6] CMCF-ID Health
Taylor, Alexander M.; Vaswani, Rishi G.; Gehling, Victor S.; Hewitt, Michael C.; Leblanc, Yves et al. (2015). Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains. ACS Medicinal Chemistry Letters 7(2) , 145-150. 10.1021/ml500411h. [PDB: 4z1s] CMCF-ID Health
Grebien, Florian; Vedadi, Masoud; Getlik, Matthäus; Giambruno, Roberto; Grover, Amit et al. (2015). Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nature Chemical Biology 11(8) , 571-578. 10.1038/nchembio.1859. [PDB: 4ql1] CMCF-ID Health
Ndubaku, Chudi O.; Crawford, Terry D.; Chen, Huifen; Boggs, Jason W.; Drobnick, Joy et al. (2015). Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Medicinal Chemistry Letters 6(8) , 913-918. 10.1021/acsmedchemlett.5b00174. CMCF-ID Health
Haji-Ghassemi, Omid; Müller-Loennies, Sven; Rodriguez, Teresa; Brade, Lore; Kosma, Paul et al. (2015). Structural Basis for Antibody Recognition of Lipid A. Journal of Biological Chemistry 290(32) , 19629-19640. 10.1074/jbc.m115.657874. [PDB: 4odt, 4odu, 4odv, 4odw, 4z8f, 4z95] CMCF-ID Health
Pfoh, Roland; Lacdao, Ira Kay; Georges, Anna A.; Capar, Adam; Zheng, Hong et al. (2015). Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7. PLoS Pathogens 11(6) , e1004950. 10.1371/journal.ppat.1004950. [PDB: 4wpi] CMCF-ID Health
Singh, Sheo B.; Kaelin, David E.; Wu, Jin; Miesel, Lynn; Tan, Christopher M. et al. (2015). Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2). Bioorganic and Medicinal Chemistry Letters 25(9) , 1831-1835. 10.1016/j.bmcl.2015.03.044. [PDB: 5bs3] CMCF-ID Health
Sivaprakasam, Prasanna; Han, Xiaojun; Civiello, Rita L.; Jacutin-Porte, Swanee; Kish, Kevin et al. (2015). Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorganic and Medicinal Chemistry Letters 25(9) , 1856-1863. 10.1016/j.bmcl.2015.03.046. [PDB: 4ptc] CMCF-ID Health