Publication Beamlines Strategic Pillar
Wrobleski, Stephen T.; Moslin, Ryan; Lin, Shuqun; Zhang, Yanlei; Spergel, Steven et al. (2019). Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. Journal of Medicinal Chemistry 62(20) . 10.1021/acs.jmedchem.9b00444. [PDB: 6nzq, 6nzr] CMCF-ID Health
Worrall, Liam J.; Vuckovic, Marija; Strynadka, Natalie C. J. (2010). Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA. Protein Science 19(5) , 1091-1096. 10.1002/pro.382. [PDB: 2x49] CMCF-ID Health
Workman, Sean D.; Worrall, Liam J.; Strynadka, Natalie C. J. (2018). Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling. Nature Communications 9(1) . 10.1038/s41467-018-03547-8. [PDB: 6cb2] CMCF-ID Health
Workman, Sean D.; Day, Jonathan; Farha, Maya A.; El Zahed, Sara S.; Bon, Chris et al. (2021). Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria. Journal of Medicinal Chemistry 64(18) , 13540–13550. 10.1021/acs.jmedchem.1c00941. [PDB: 7jli] CMCF-ID Health
Wong King Yuen, Siobhan M.; Campiglio, Marta; Tung, Ching-Chieh; Flucher, Bernhard E.; Van Petegem, Filip et al. (2017). Structural insights into binding of STAC proteins to voltage-gated calcium channels. Proceedings of the National Academy of Sciences of the United States of America 114(45) , 201708852. 10.1073/pnas.1708852114. [PDB: 6b29] CMCF-ID Health
Wong, Joyce J. W.; Lu, Jun; Edwards, Ross A.; Frost, Laura S.; Glover, J. N. Mark et al. (2011). Structural basis of cooperative DNA recognition by the plasmid conjugation factor, TraM. Nucleic Acids Research 39(15) , 6775-6788. 10.1093/nar/gkr296. CMCF-BM, CMCF-ID Health
Wong, Alan H.M.; Zhou, Dongxia; Rini, James M. (2012). The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing. Journal of Biological Chemistry 287(44) , 36804-36813. 10.1074/jbc.m112.398842. [PDB: 4fyq, 4fyr, 4fys, 4fyt] CMCF-ID Health
Wong, Alan H. M.; Tomlinson, Aidan C. A.; Zhou, Dongxia; Satkunarajah, Malathy; Chen, Kevin et al. (2017). Receptor-binding loops in alphacoronavirus adaptation and evolution. Nature Communications 8(1) . 10.1038/s41467-017-01706-x. [PDB: 6atk] CMCF-ID Health
Wiseman, Ben; Carpena, Xavi; Feliz, Miguel; Donald, Lynda J.; Pons, Miquel et al. (2010). Isonicotinic Acid Hydrazide Conversion to Isonicotinyl-NAD by Catalase-peroxidases. Journal of Biological Chemistry 285(34) , 26662-26673. 10.1074/jbc.m110.139428. [PDB: 5sxq, 5sxr, 5sxs, 5sxt, 5sxw, 5sxx] CMCF-ID Health
Wilsbacher, Julie L.; Cheng, Min; Cheng, Dong; Trammell, Samuel A.J.; Shi, Yan et al. (2017). Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Molecular Cancer Therapeutics 16(7) , 1236-1245. 10.1158/1535-7163.mct-16-0819. [PDB: 5u2m] CMCF-ID Health
Wilding, Birgit; Scharn, Dirk; Böse, Dietrich; Baum, Anke; Santoro, Valeria et al. (2022). Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling. Nature Cancer 3(7) , 821-836. 10.1038/s43018-022-00412-y. [PDB: 7pcd] CMCF-ID Health
Wigle, Tim J.; Ren, Yue; Molina, Jennifer R.; Blackwell, Danielle J.; Schenkel, Laurie B. et al. (2021). Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule. ChemBioChem 22(12) . 10.1002/cbic.202100047. [PDB: 7l9y] CMCF-ID Health
Whitesell, Luke; Robbins, Nicole; Huang, David S.; McLellan, Catherine A.; Shekhar-Guturja, Tanvi et al. (2019). Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications 10(1) , 402. 10.1038/s41467-018-08248-w. [PDB: 6cjl, 6cjp] CMCF-ID Health
White, E. Railey; Sun, Luxin; Ma, Zhong; Beckta, Jason M.; Danzig, Brittany A. et al. (2015). Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain. ACS Chemical Biology 10(5) , 1198-1208. 10.1021/cb500757u. [PDB: 4ofb] CMCF-BM, CMCF-ID Health
White, Brandy; Patterson, Michelle; Karnwal, Saloni; Brooks, Cory L. (2022). Crystal structure of a human MUC16 SEA domain reveals insight into the nature of the CA125 tumor marker. Proteins: Structure. Function and Bioinformatics 90(5) . 10.1002/prot.26303. [PDB: 7sa9] CMCF-ID Health