Publication Beamlines Strategic Pillar
Fraser, Bryan J.; Young, Nicholas J.; Bender, Brian J.; Gahbauer, Stefan; Ilyassov, Olzhas et al. (2025). Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors. Journal of Medicinal Chemistry 68(19) , 19893-19907. 10.1021/acs.jmedchem.4c03089. CMCF-ID Health
Higgins, Melanie A.; Shi, Xinjie; Soler, Jordi; Harland, Jill B.; Parkkila, Taylor et al. (2025). Structure and mechanism of haem-dependent nitrogen–nitrogen bond formation in piperazate synthase. Nature Catalysis 8(3) , 207-217. 10.1038/s41929-024-01280-8. CMCF-ID Materials
Fraser, Bryan J.; Wilson, Ryan P.; Ferková, Sára; Ilyassov, Olzhas; Lac, Jackie et al. (2025). Structural basis of TMPRSS11D specificity and autocleavage activation. Nature Communications 16(1) . 10.1038/s41467-025-59677-3. CMCF-ID Health
Puumala, Emily; Nandakumar, Meganathan; Yiu, Bonnie; Stogios, Peter J.; Strickland, Benjamin G. et al. (2025). Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans. Nature Communications 16(1) . 10.1038/s41467-025-57346-z. CMCF-ID Health
Nguyen, Quynh Huong; Lai, Chun Heng Royce; Norris, Michael J.; Ng, Dixon; Shah, Megha et al. (2025). A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion. PLoS Pathogens 21(5) , e1012686. 10.1371/journal.ppat.1012686. CMCF-ID Health
Xiao, Qin; Wang, Yu; Shang, Xinci; Chen, Yichang; Zhang, Ming et al. (2026). Structural basis for sequence-specific DNA recognition by a group IId WRKY transcription factor GhWRKY17 in cotton. Biochemical Journal 483(2) , 149-160. 10.1042/bcj20250191. [PDB: 9m0k] CMCF-ID Agriculture
Ivanochko, Danton; Miura, Kazutoyo; Hailemariam, Sophia; Ravichandran, Rashmi; Song, Yiting et al. (2026). A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity. Nature Communications . 10.1038/s41467-026-68761-1. CMCF-ID Health
Govind, Manitabhai; Allas, Mikel Jason; Huang, Bo-Shun; Lowary, Todd L.; Kimber, Matthew S. et al. (2026). The retaining kdo transferase that synthesizes Escherichia coli K13 capsule is deeply divergent from structurally homologous enzymes. Journal of Biological Chemistry 302(3) , 111162. 10.1016/j.jbc.2026.111162. [PDB: 9yfx] CMCF-ID Health
Haines, Eric; Burke, Michael; Catterall, Rachel; De Jesus, Victor; Hidalgo, Daniel et al. (2026). The MEK–RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers. Nature Cancer . 10.1038/s43018-025-01081-3. [PDB: 9ecu] CMCF-ID Health
Guo, Shuaiqi; Zahiri, Hossein; Stevens, Corey; Spaanderman, Daniel C.; Milroy, Lech-Gustav et al. (2021). Molecular basis for inhibition of adhesin-mediated bacterial-host interactions through a peptide-binding domain. Cell Reports 37(7) , 110002. 10.1016/j.celrep.2021.110002. [PDB: 6x5v, 6x5w] CMCF-ID Agriculture
Kwon, Min Chul; Thuring, Jan Willem; Querolle, Olivier; Dai, Xuedong; Verhulst, Tinne et al. (2024). Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias. Blood 144(11) , 1206-1220. 10.1182/blood.2023022480. [PDB: 9z4x] CMCF-ID Health
Kimani, Serah W.; Noureldin, Mahmoud; Wilson, Brian; Hoffer, Laurent; Green, Stuart R. et al. (2025). OICR-41103 as a chemical probe for the DCAF1 WD40 domain. Communications Biology 8(1) . 10.1038/s42003-025-08491-0. [PDB: 9yv4] CMCF-ID Health
Wang, Mingyu; Du, Grace; Yongo‐Luwawa, Charity; Lu, Angelina; Kinrade, Brett et al. (2025). Peptide‐based ligand antagonists block a Vibrio cholerae adhesin. FEBS Letters . 10.1002/1873-3468.70231. [PDB: 9y9w, 9ybq] CMCF-ID Health
Luo, Chuanyun; Paetzel, Mark (2025). Crystal structure of Escherichia coli type I signal peptidase P84A in complex with lipopeptide antibiotic arylomycin A2. Journal of Structural Biology 217(4) , 108260. 10.1016/j.jsb.2025.108260. [PDB: 9nlo] CMCF-ID Health
Forrester, Taylor J. B.; Lin, Sicheng; Lowary, Todd L.; Kimber, Matthew S. (2025). WrtF from Rhizobium tropici CIAT 899 is a GT-A fold fucosyltransferase that binds its donor nonproductively. Proceedings of the National Academy of Sciences of the United States of America 122(44) . 10.1073/pnas.2512460122. [PDB: 9omh, 9omi] CMCF-BM, CMCF-ID Agriculture