| Park, J.; Leung, C.Y.; Tsantrizos, Y.S.; Berghuis, A.M. (2017). Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-066. Protein Data Bank: 5jv1. |
CMCF-ID |
PDB Deposition |
Health |
| Park, J.; Leung, C.Y.; Tsantrizos, Y.S.; Berghuis, A.M. (2014). Crystal structure of human FPPS in complex with CL03093. Protein Data Bank: 4lph. |
CMCF-ID |
PDB Deposition |
Health |
| Park, J.; Leung, C.Y.; Tsantrizos, Y.S.; Berghuis, A.M. (2014). Crystal structure of human FPPS in complex with CL01131. Protein Data Bank: 4lpg. |
CMCF-ID |
PDB Deposition |
Health |
| Park, J.; Leung, C.-Y.; Tsantrizos, Y.S.; Berghuis, A.M. (2014). Crystal structure of human FPPS in complex with magnesium, CL02134, and inorganic pyrophosphate. Protein Data Bank: 4l2x. |
CMCF-ID |
PDB Deposition |
Health |
| Park, J.; Leung, C.-Y.; Tsantrizos, Y.S.; Berghuis, A.M. (2014). Crystal structure of human FPPS in complex with magnesium, CL01131, and sulfate. Protein Data Bank: 4jvj. |
CMCF-ID |
PDB Deposition |
Health |
| Park, J.; De Schutter, J.W.; Tsantrizos, Y.S.; Berghuis, A.M. (2014). Crystal structure of human FPPS in complex with magnesium, JDS05120, and sulfate. Protein Data Bank: 4nfj. |
CMCF-ID |
PDB Deposition |
Health |
| Park, J.; De Schutter, J.W.; Tsantrizos, Y.S.; Berghuis, A.M. (2014). Crystal structure of human FPPS in complex with magnesium and JDS05120. Protein Data Bank: 4nfi. |
CMCF-ID |
PDB Deposition |
Health |
| Park, J.; De schutter, J.W.; Tsantrizos, Y.S.; Berghuis, A.M. (2014). Crystal structure of human FPPS in complex with nickel, JDS05120, and sulfate. Protein Data Bank: 4nfk. |
CMCF-ID |
PDB Deposition |
Health |
| Park, J.; Bin, X.; Vincent, F.; Tsantrizos, Y.S.; Berghuis, A.M. et al. (2018). Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in complex with bisphosphonate inhibitor FV0109. Protein Data Bank: 6c57. |
CMCF-ID |
PDB Deposition |
Health |
| Park, J.; Berghuis, A.M. (2019). Crystal structure of human FPPS in complex with an allosteric inhibitor MIT-01-102. Protein Data Bank: 6n7y. |
CMCF-ID |
PDB Deposition |
Health |
| Park, J.; Berghuis, A.M. (2019). Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02-78. Protein Data Bank: 6oah. |
CMCF-ID |
PDB Deposition |
Health |
| Park, J.; Berghuis, A.M. (2019). Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02-82. Protein Data Bank: 6oag. |
CMCF-ID |
PDB Deposition |
Health |
| Park, Jaeok; Zielinski, Michal; Magder, Alexandr; Tsantrizos, Youla S.; Berghuis, Albert M. et al. (2017). Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product. Nature Communications 8(1) . 10.1038/ncomms14132. [PDB: 5ja0] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Park, Jaeok; Rodionov, Dmitry; De Schutter, Joris W.; Lin, Yih-Shyan; Tsantrizos, Youla S. et al. (2017). Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. PLoS ONE 12(10) , e0186447. 10.1371/journal.pone.0186447. [PDB: 4nfi, 4nfj, 4nfk] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Park, Jaeok; Lin, Yih-Shyan; Tsantrizos, Youla S.; Berghuis, Albert M. (2014). Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallographica Section F Structural Biology and Crystallization Communications 70(3) , 299-304. 10.1107/s2053230x14002106. [PDB: 4lfv] |
CMCF-ID |
Peer-Reviewed Article |
Health |