Publication Beamlines Strategic Pillar
Picard, Marie-Ève; Nisole, Audrey; Béliveau, Catherine; Sen, Stephanie; Barbar, Aline et al. (2018). Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana : Implications for inhibitor design. Insect Biochemistry and Molecular Biology 92, 84-92. 10.1016/j.ibmb.2017.11.011. [PDB: 6b02, 6b04, 6b06] CMCF-ID Health
Pfoh, Roland; Li, Angela; Chakrabarti, Nilmadhab; Payandeh, Jian; Pomès, Régis et al. (2012). Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation. Proceedings of the National Academy of Sciences of the United States of America 109(46) , 18809-18814. 10.1073/pnas.1209018109. [PDB: 4eeb, 4eed] CMCF-ID Health
Pfoh, Roland; Lacdao, Ira Kay; Georges, Anna A.; Capar, Adam; Zheng, Hong et al. (2015). Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7. PLoS Pathogens 11(6) , e1004950. 10.1371/journal.ppat.1004950. [PDB: 4wpi] CMCF-ID Health
Petrilli, Whitney L.; Adam, Gregory C.; Erdmann, Roman S.; Abeywickrema, Pravien; Agnani, Vijayalakshmi et al. (2020). From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chemical Biology 27(1) , 32-40. 10.1016/j.chembiol.2019.10.002. [PDB: 6u36] CMCF-ID Health
Petkun, Svetlana; Shi, Rong; Li, Yunge; Asinas, Abdalin; Munger, Christine et al. (2011). Structure of Hydrogenase Maturation Protein HypF with Reaction Intermediates Shows Two Active Sites. Structure 19(12) , 1773-1783. 10.1016/j.str.2011.09.023. [PDB: 3tsp, 3tsq, 3tsu, 3ttc, 3ttd, 3ttf] CMCF-ID Health
Perez-Bermejo, Juan A.; Efagene, Oghene; Matern, William M.; Holden, Jeffrey K.; Kabir, Shaheen et al. (2024). Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair. Nature Communications 15(1) . 10.1038/s41467-024-46816-5. [PDB: 8svg, 8svh, 8svi] CMCF-ID Health
Peña, Kerry L.; Castel, Stephane E.; de Araujo, Charlotte; Espie, George S.; Kimber, Matthew S. et al. (2010). Structural basis of the oxidative activation of the carboxysomal γ-carbonic anhydrase, CcmM. Proceedings of the National Academy of Sciences of the United States of America 107(6) , 2455-2460. 10.1073/pnas.0910866107. CMCF-ID Health
Partha, Sarathy Karunan; Sadeghi-Khomami, Ali; Slowski, Kathryn; Kotake, Toshihisa; Thomas, Neil R. et al. (2010). Chemoenzymatic Synthesis, Inhibition Studies, and X-ray Crystallographic Analysis of the Phosphono Analog of UDP-Galp as an Inhibitor and Mechanistic Probe for UDP-Galactopyranose Mutase. Journal of Molecular Biology 403(4) , 578-590. 10.1016/j.jmb.2010.08.053. [PDB: 3mj4] CMCF-ID Health
Park, Jaeok; Zielinski, Michal; Magder, Alexandr; Tsantrizos, Youla S.; Berghuis, Albert M. et al. (2017). Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product. Nature Communications 8(1) . 10.1038/ncomms14132. [PDB: 5ja0] CMCF-ID Health
Park, Jaeok; Rodionov, Dmitry; De Schutter, Joris W.; Lin, Yih-Shyan; Tsantrizos, Youla S. et al. (2017). Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. PLoS ONE 12(10) , e0186447. 10.1371/journal.pone.0186447. [PDB: 4nfi, 4nfj, 4nfk] CMCF-ID Health
Park, Jaeok; Lin, Yih-Shyan; Tsantrizos, Youla S.; Berghuis, Albert M. (2014). Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallographica Section F Structural Biology and Crystallization Communications 70(3) , 299-304. 10.1107/s2053230x14002106. [PDB: 4lfv] CMCF-ID Health
Park, Jaeok; Leung, Chun Yuen; Matralis, Alexios N.; Lacbay, Cyrus M.; Tsakos, Michail et al. (2017). Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. Journal of Medicinal Chemistry 60(5) , 2119-2134. 10.1021/acs.jmedchem.6b01888. [PDB: 5juz, 5jv1] CMCF-ID Health
Parker, Michelle L.; Penarete-Vargas, Diana M.; Hamilton, Phineas T.; Guérin, Amandine; Dubey, Jitender P. et al. (2015). Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA–RON2 pair. Proceedings of the National Academy of Sciences of the United States of America 113(2) , 398-403. 10.1073/pnas.1515898113. [PDB: 4z80, 4z81] CMCF-ID Health
Parker, Michelle L.; Houston, Simon; Wetherell, Charmaine; Cameron, Caroline E.; Boulanger, Martin J. et al. (2016). The Structure of Treponema pallidum Tp0624 Reveals a Modular Assembly of Divergently Functionalized and Previously Uncharacterized Domains. PLoS ONE 11(11) , e0166274. 10.1371/journal.pone.0166274. [PDB: 5jir] CMCF-ID Health
Parker, Michelle L.; Houston, Simon; Pětrošová, Helena; Lithgow, Karen V.; Hof, Rebecca et al. (2016). The Structure of Treponema pallidum Tp0751 (Pallilysin) Reveals a Non-canonical Lipocalin Fold That Mediates Adhesion to Extracellular Matrix Components and Interactions with Host Cells. PLoS Pathogens 12(9) , e1005919. 10.1371/journal.ppat.1005919. [PDB: 5jk2] CMCF-ID Health