Publication Beamlines Strategic Pillar
Workman, Sean D.; Day, Jonathan; Farha, Maya A.; El Zahed, Sara S.; Bon, Chris et al. (2021). Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria. Journal of Medicinal Chemistry 64(18) , 13540–13550. 10.1021/acs.jmedchem.1c00941. [PDB: 7jli] CMCF-ID Health
Workman, Sean D.; Worrall, Liam J.; Strynadka, Natalie C. J. (2018). Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling. Nature Communications 9(1) . 10.1038/s41467-018-03547-8. [PDB: 6cb2] CMCF-ID Health
Worrall, Liam J.; Vuckovic, Marija; Strynadka, Natalie C. J. (2010). Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA. Protein Science 19(5) , 1091-1096. 10.1002/pro.382. [PDB: 2x49] CMCF-ID Health
Wrobleski, Stephen T.; Moslin, Ryan; Lin, Shuqun; Zhang, Yanlei; Spergel, Steven et al. (2019). Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. Journal of Medicinal Chemistry 62(20) . 10.1021/acs.jmedchem.9b00444. [PDB: 6nzq, 6nzr] CMCF-ID Health
Wu, Hong; Siarheyeva, Alena; Zeng, Hong; Lam, Robert; Dong, Aiping et al. (2013). Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2. FEBS Letters 587(23) , 3859-3868. 10.1016/j.febslet.2013.10.020. [PDB: 3s8p] CMCF-ID Health
Wu, Hong; Zeng, Hong; Dong, Aiping; Li, Fengling; He, Hao et al. (2013). Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations. PLoS ONE 8(12) , e83737. 10.1371/journal.pone.0083737. [PDB: 4mi0] CMCF-ID Health
Wu, Hong; Zeng, Hong; Lam, Robert; Tempel, Wolfram; Amaya, Maria F. et al. (2011). Structural and Histone Binding Ability Characterizations of Human PWWP Domains. PLoS ONE 6(6) , e18919. 10.1371/journal.pone.0018919. [PDB: 3llr, 3lyi] CMCF-ID Health
Wu, Wen-Lian; Hao, Jinsong; Domalski, Martin; Burnett, Duane A.; Pissarnitski, Dmitri et al. (2016). Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. ACS Medicinal Chemistry Letters 7(5) , 498-501. 10.1021/acsmedchemlett.6b00027. [PDB: 5i7u] CMCF-ID Health
Wu, Yong-Jin; Guernon, Jason; Shi, Jianliang; Marcin, Lawrence; Higgins, Mendi et al. (2016). Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors. Journal of Medicinal Chemistry 59(18) , 8593-8600. 10.1021/acs.jmedchem.6b01012. [PDB: 5kr8] CMCF-ID Health
Wyrzucki, Arkadiusz; Dreyfus, Cyrille; Kohler, Ines; Steck, Marco; Wilson, Ian A. et al. (2014). Alternative Recognition of the Conserved Stem Epitope in Influenza A Virus Hemagglutinin by a V H 3-30-Encoded Heterosubtypic Antibody. Journal of Virology 88(12) , 7083-7092. 10.1128/jvi.00178-14. [PDB: 4py8] CMCF-ID Health
Xiong, Yumei; Walker, Kenneth; Min, Xiaoshan; Hale, Clarence; Tran, Thanhvien et al. (2017). Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys. Science Translational Medicine 9(412) , eaan8732. 10.1126/scitranslmed.aan8732. [PDB: 5vt2] CMCF-ID Health
Xu, Chao; Bian, Chuanbing; Yang, Wei; Galka, Marek; Ouyang, Hui et al. (2010). Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proceedings of the National Academy of Sciences of the United States of America 107(45) , 19266-19271. 10.1073/pnas.1008937107. CMCF-ID Health
Xu, Chao; Liu, Ke; Lei, Ming; Yang, Ally; Li, Yanjun et al. (2018). DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. Structure 26(1) , 85-95.e3. 10.1016/j.str.2017.11.022. [PDB: 5w9q] CMCF-ID Health
Xu, Shangyi; Grochulski, Pawel; Tanaka, Takuji (2024). Structural basis for the allosteric behaviour and substrate specificity of Lactococcus lactis Prolidase. Biochimica et Biophysica Acta - Proteins and Proteomics 1872(3) , 141000. 10.1016/j.bbapap.2024.141000. CMCF-BM, CMCF-ID Health
Xu, Yufei; Xu, Chao; Kato, Akiko; Tempel, Wolfram; Abreu, Jose Garcia et al. (2012). Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development. Cell 151(6) , 1200-1213. 10.1016/j.cell.2012.11.014. [PDB: 4hp1, 4hp3] CMCF-ID Health