Publication Beamlines Strategic Pillar
De Schutter, Joris W.; Park, Jaeok; Leung, Chun Yuen; Gormley, Patrick; Lin, Yih-Shyan et al. (2014). Multistage Screening Reveals Chameleon Ligands of the Human Farnesyl Pyrophosphate Synthase: Implications to Drug Discovery for Neurodegenerative Diseases. Journal of Medicinal Chemistry 57(13) , 5764-5776. 10.1021/jm500629e. [PDB: 4lpg, 4lph] CMCF-ID Health
Lau, Kelvin; Van Petegem, Filip (2014). Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain. Nature Communications 5(1) . 10.1038/ncomms6397. [PDB: 4p9i] CMCF-ID Health
Krska, Daniel; Ravulapalli, Ravikiran; Fieldhouse, Robert J.; Lugo, Miguel R.; Merrill, A. Rod et al. (2015). C3larvin Toxin, an ADP-ribosyltransferase from Paenibacillus larvae. Journal of Biological Chemistry 290(3) , 1639-1653. 10.1074/jbc.m114.589846. [PDB: 4tr5] CMCF-ID Health
Kalynych, Sergei; Cherney, Maia; Bostina, Mihnea; Rouiller, Isabelle; Cygler, Miroslaw et al. (2014). Quaternary structure of WzzB and WzzE polysaccharide copolymerases. Protein Science 24(1) , 58-69. 10.1002/pro.2586. CMCF-ID Health
Huh, Ian; Gene, Robert; Kumaran, Jyothi; MacKenzie, C. Roger; Brooks, Cory L. et al. (2014). In situproteolysis, crystallization and preliminary X-ray diffraction analysis of a VHH that binds listeria internalin B. Acta Crystallographica Section F:Structural Biology Communications 70(11) , 1532-1535. 10.1107/s2053230x1402010x. CMCF-ID Health
Johal, A. R.; Blackler, R. J.; Alfaro, J. A.; Schuman, B.; Borisova, S. et al. (2013). pH-induced conformational changes in human ABO(H) blood group glycosyltransferases confirm the importance of electrostatic interactions in the formation of the semi-closed state. Glycobiology 24(3) , 237-246. 10.1093/glycob/cwt098. [PDB: 4fre, 4frh, 4frl, 4frm, 4fro, 4frp, 4frq] CMCF-ID Health
Parker, Matthew J; Gomery, Kathryn; Richard, Gabrielle; MacKenzie, C Roger; Cox, Andrew D et al. (2014). Structural basis for selective cross-reactivity in a bactericidal antibody against inner core lipooligosaccharide from Neisseria meningitidis†,‡. Glycobiology 24(5) , 442-449. 10.1093/glycob/cwu009. [PDB: 4c83, 4rqx] CMCF-ID Health
Duan, James J.-W.; Lu, Zhonghui; Jiang, Bin; Yang, Bingwei V.; Doweyko, Lidia M. et al. (2014). Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors. Bioorganic and Medicinal Chemistry Letters 24(24) , 5721-5726. 10.1016/j.bmcl.2014.10.061. [PDB: 4rio] CMCF-ID Health
Vadlamani, Grishma; Thomas, Misty D.; Patel, Trushar R.; Donald, Lynda J.; Reeve, Thomas M. et al. (2015). The β-Lactamase Gene Regulator AmpR Is a Tetramer That Recognizes and Binds the d-Ala-d-Ala Motif of Its Repressor UDP-N-acetylmuramic Acid (MurNAc)-pentapeptide. Journal of Biological Chemistry 290(5) , 2630-2643. 10.1074/jbc.m114.618199. [PDB: 4wkm] CMCF-ID Health
Doores, Katie J.; Kong, Leopold; Krumm, Stefanie A.; Le, Khoa M.; Sok, Devin et al. (2015). Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope. Journal of Virology 89(2) , 1105-1118. 10.1128/jvi.02905-14. [PDB: 4rnr] CMCF-ID Health
Chan, Anson C.K.; Blair, Kris M.; Liu, Yanjie; Frirdich, Emilisa; Gaynor, Erin C. et al. (2015). Helical Shape of Helicobacter pylori Requires an Atypical Glutamine as a Zinc Ligand in the Carboxypeptidase Csd4. Journal of Biological Chemistry 290(6) , jbc.M114.624734. 10.1074/jbc.m114.624734. [PDB: 4wck, 4wcl, 4wcm, 4wcn] CMCF-BM, CMCF-ID Health
Chamberlain, Philip P; Lopez-Girona, Antonia; Miller, Karen; Carmel, Gilles; Pagarigan, Barbra et al. (2014). Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nature Structural and Molecular Biology 21(9) , 803-809. 10.1038/nsmb.2874. CMCF-ID Health
Cappadocia, Laurent; Mascle, Xavier H.; Bourdeau, Véronique; Tremblay-Belzile, Samuel; Chaker-Margot, Malik et al. (2015). Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1. Structure 23(1) , 126-138. 10.1016/j.str.2014.10.015. [PDB: 4wjn] CMCF-ID Health
White, E. Railey; Sun, Luxin; Ma, Zhong; Beckta, Jason M.; Danzig, Brittany A. et al. (2015). Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain. ACS Chemical Biology 10(5) , 1198-1208. 10.1021/cb500757u. [PDB: 4ofb] CMCF-BM, CMCF-ID Health
Loewen, Peter C.; Villanueva, Jacylyn; Switala, Jacek; Donald, Lynda J.; Ivancich, Anabella et al. (2015). Unprecedented access of phenolic substrates to the heme active site of a catalase: Substrate binding and peroxidase-like reactivity ofBacillus pumiluscatalase monitored by X-ray crystallography and EPR spectroscopy. Proteins: Structure. Function and Bioinformatics 83(5) , 853-866. 10.1002/prot.24777. [PDB: 4qol, 4qom, 4qon, 4qoo, 4qop, 4qoq] CMCF-ID Health