Publication Beamlines Strategic Pillar
Zheng, Xiaozhang; Baumeister, Timm; Buckmelter, Alexandre J.; Caligiuri, Maureen; Clodfelter, Karl H. et al. (2014). Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorganic and Medicinal Chemistry Letters 24(1) , 337-343. 10.1016/j.bmcl.2013.11.006. [PDB: 4lww] CMCF-ID Health
Yao, Deqiang; Cherney, Maia; Cygler, Miroslaw (2014). Structure of the N-terminal domain of the effector protein LegC3 fromLegionella pneumophila. Acta Crystallographica Section D Biological Crystallography 70(2) , 436-441. 10.1107/s139900471302991x. [PDB: 4mu6] CMCF-ID Health
Vidossich, Pietro; Loewen, Peter C.; Carpena, Xavi; Fiorin, Giacomo; Fita, Ignacio et al. (2014). Binding of the Antitubercular Pro-Drug Isoniazid in the Heme Access Channel of Catalase-Peroxidase (KatG). A Combined Structural and Metadynamics Investigation. Journal of Physical Chemistry B 118(11) , 2924-2931. 10.1021/jp4123425. [PDB: 5syi] CMCF-ID Health
Thi, Nhung Nguyen; Offen, Wendy A.; Shareck, François; Davies, Gideon J.; Doucet, Nicolas et al. (2014). Structure and Activity of the Streptomyces coelicolor A3(2) β-N-Acetylhexosaminidase Provides Further Insight into GH20 Family Catalysis and Inhibition. Biochemistry 53(11) , 1789-1800. 10.1021/bi401697j. [PDB: 4c7f] CMCF-ID Health
Sweeting, Braden (2014). The structural basis of prion disease susceptibility and the transmission barrier. Supervisor: Pai, Emil F.. Canada, ON: University of Toronto. http://hdl.handle.net/1807/43717. CMCF-ID Health
Sheriff, S. (2014). Human tau tubulin kinase 1 (TTBK1). Protein Data Bank: 4nfm. CMCF-ID Health
Pustilnik, A.; Lewis, S.M.; Wu, X.; Sereno, A.; Huang, F. et al. (2014). Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain lambda constant domain (IgG1 CH1:Clambda) at 1.19A. Protein Data Bank: 4lld. CMCF-ID Health
Park, J.; Lin, Y.-S.; Tsantrizos, Y.S.; Berghuis, A.M. (2014). Crystal structure of human FPPS in complex with YS0470 and two molecules of inorganic phosphate. Protein Data Bank: 4lfv. CMCF-ID Health
Park, J.; Leung, C.-Y.; Tsantrizos, Y.S.; Berghuis, A.M. (2014). Crystal structure of human FPPS in complex with magnesium, CL02134, and inorganic pyrophosphate. Protein Data Bank: 4l2x. CMCF-ID Health
Park, J.; Leung, C.-Y.; Tsantrizos, Y.S.; Berghuis, A.M. (2014). Crystal structure of human FPPS in complex with magnesium, CL01131, and sulfate. Protein Data Bank: 4jvj. CMCF-ID Health
Park, Jaeok; Lin, Yih-Shyan; Tsantrizos, Youla S.; Berghuis, Albert M. (2014). Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallographica Section F Structural Biology and Crystallization Communications 70(3) , 299-304. 10.1107/s2053230x14002106. [PDB: 4lfv] CMCF-ID Health
Parker, M.J.; Gomery, K.; Richard, G.; Mackenzie, C.R.; Cox, A.D. et al. (2014). Crystal Structure of the IgG2a LPT3 in complex with an 8-sugar inner core analogue of Neisseria meningitidis. Protein Data Bank: 4c83. CMCF-ID Health
Parker, Matthew J; Gomery, Kathryn; Richard, Gabrielle; MacKenzie, C Roger; Cox, Andrew D et al. (2014). Structural basis for selective cross-reactivity in a bactericidal antibody against inner core lipooligosaccharide from Neisseria meningitidis†,‡. Glycobiology 24(5) , 442-449. 10.1093/glycob/cwu009. [PDB: 4c83, 4rqx] CMCF-ID Health
Nguyen Thi, N.; Offen, W.A.; Davies, G.J.; Doucet, N. (2014). Structure and activity of the GH20 beta-N-acetylhexosaminidase from Streptomyces coelicolor A3(2). Protein Data Bank: 4c7f. CMCF-ID Health
Lewis, Steven M; Wu, Xiufeng; Pustilnik, Anna; Sereno, Arlene; Huang, Flora et al. (2014). Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nature Biotechnology 32(2) , 191-198. 10.1038/nbt.2797. [PDB: 4lld] CMCF-ID Health