Publication Beamlines Strategic Pillar
Lewis, Steven M; Wu, Xiufeng; Pustilnik, Anna; Sereno, Arlene; Huang, Flora et al. (2014). Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nature Biotechnology 32(2) , 191-198. 10.1038/nbt.2797. [PDB: 4lld] CMCF-ID Health
Lewis, Melissa; Meza-Avina, Maria Elena; Wei, Lianhu; Crandall, Ian E.; Bello, Angelica Mara et al. (2011). Novel Interactions of Fluorinated Nucleotide Derivatives Targeting Orotidine 5′-Monophosphate Decarboxylase. Journal of Medicinal Chemistry 54(8) , 2891-2901. 10.1021/jm101642g. [PDB: 3mo7] CMCF-ID Health
Lewis, H.A.; Wu, Y.J.; Rajamani, R.; Thompson, L.A. (2016). (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine (compound 5) bound to BACE1. Protein Data Bank: 5kr8. CMCF-ID Health
Lewis, H.A.; Sivaprakasam, P.; Kish, K.; Pokross, M.; Dubowchik, G.M. et al. (2015). Structure of a carboxamide compound (3) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-OXO-4H-1LAMBDA~4~,3-THIAZOLE-5-CARBOXAMIDE) to GSK3b. Protein Data Bank: 4ptc. CMCF-ID Health
Lewis, H.A.; Muckelbauer, J.K. (2022). CRYSTAL STRUCTURE OF HIV-1 INTEGRASE COMPLEXED WITH (2S)-2-(TERT-BUTOXY)-2-(5-{2-[(2-CHLORO-6-M ETHYLPHENYL)METHYL]-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL}-4- (4,4-DIMETHYLPIPERIDIN-1-YL)-2-METHYLPYRIDIN-3-YL)ACETIC ACID. Protein Data Bank: 7uoq. CMCF-ID Health
Leung, K.K.; Shilton, B.H. (2013). Reduced quinone reductase 2 in complex with chloroquine. Protein Data Bank: 4fgl. CMCF-ID Health
Leung, Kevin K.K.; Shilton, Brian H. (2013). Chloroquine Binding Reveals Flavin Redox Switch Function of Quinone Reductase 2. Journal of Biological Chemistry 288(16) , 11242-11251. 10.1074/jbc.m113.457002. CMCF-ID Health
Leung, Kevin K. K.; Shilton, Brian H. (2014). Quinone Reductase 2 Is an Adventitious Target of Protein Kinase CK2 Inhibitors TBBz (TBI) and DMAT. Biochemistry 54(1) , 47-59. 10.1021/bi500959t. [PDB: 4u7h] CMCF-ID Health
Leung, Kevin Ka Ki; Litchfield, David W.; Shilton, Brian H. (2012). Flavin adenine dinucleotide content of quinone reductase 2: Analysis and optimization for structure–function studies. Analytical Biochemistry 420(1) , 84-89. 10.1016/j.ab.2011.09.011. CMCF-ID Health
Leung, Kevin Ka Ki (2015). Quinone Reductase 2 is a Flavin Redox Switch. Supervisor: Shilton, Brian. Ontario, Canada: University of Western Ontario. http://ir.lib.uwo.ca/etd/3226/. CMCF-ID Health
Leung, Chun Yuen; Park, Jaeok; De Schutter, Joris W.; Sebag, Michael; Berghuis, Albert M. et al. (2013). Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition. Journal of Medicinal Chemistry 56(20) , 7939-7950. 10.1021/jm400946f. [PDB: 4jvj, 4l2x] CMCF-ID Health
Leung, Charles Chung Yun; Sun, Luxin; Gong, Zihua; Burkat, Michael; Edwards, Ross et al. (2013). Structural Insights into Recognition of MDC1 by TopBP1 in DNA Replication Checkpoint Control. Structure 21(8) , 1450-1459. 10.1016/j.str.2013.06.015. [PDB: 3ueo] CMCF-ID Health
Leung, Charles Chung Yun; Kellogg, Elizabeth; Kuhnert, Anja; Hänel, Frank; Baker, David et al. (2009). Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIβ binding protein 1. Protein Science , 162-167. 10.1002/pro.290. [PDB: 3jve] CMCF-ID Health
Leung, Charles Chung Yun; Gong, Zihua; Chen, Junjie; Glover, J. N. Mark (2011). Molecular Basis of BACH1/FANCJ Recognition by TopBP1 in DNA Replication Checkpoint Control. Journal of Biological Chemistry 286(6) , 4292-4301. 10.1074/jbc.m110.189555. [PDB: 3al2, 3al3] CMCF-ID Health
Leung, Charles (2011). Molecular basis of TopBP1 BRCT domain interactions in the DNA damage response. Supervisor: Glover, Mark. AB, Canada: University of Alberta. https://doi.org/10.7939/R3Q42H. CMCF-ID Agriculture