Publication Beamlines Strategic Pillar
Vance, Tyler D. R.; Guo, Shuaiqi; Assaie-Ardakany, Shayan; Conroy, Brigid; Davies, Peter L. et al. (2019). Structure and functional analysis of a bacterial adhesin sugar-binding domain. PLoS ONE 14(7) , e0220045. 10.1371/journal.pone.0220045. [PDB: 6m8m] CMCF-ID Health
Velagapudi, Uday Kiran; Langelier, Marie-France; Delgado-Martin, Cristina; Diolaiti, Morgan E.; Bakker, Sietske et al. (2019). Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. Journal of Medicinal Chemistry 62(11) , 5330-5357. 10.1021/acs.jmedchem.8b01709. [PDB: 6nrf, 6nrg, 6nrh, 6nri, 6nrj] CMCF-ID Health
Von Dwingelo, Juanita; Chung, Ivy Yeuk Wah; Price, Christopher T.; Li, Lei; Jones, Snake et al. (2019). Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex. mBio 10(4) , e01942-19. 10.1128/mbio.01942-19. [PDB: 6mca] CMCF-BM, CMCF-ID Health
Wei, Yong; Resetca, Diana; Li, Zhe; Johansson-Åkhe, Isak; Ahlner, Alexandra et al. (2019). Multiple direct interactions of TBP with the MYC oncoprotein. Nature Structural and Molecular Biology 26(11) , 1035-1043. 10.1038/s41594-019-0321-z. [PDB: 6e24] CMCF-ID Health
Wei, Yong; Xiong, Zi Jian; Li, Jun; Zou, Chunxia; Cairo, Christopher W. et al. (2019). Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters. Communications Biology 2(1) . 10.1038/s42003-018-0262-9. [PDB: 6e7o] CMCF-ID Health
White, Brandy; Huh, Ian; Brooks, Cory L. (2019). Structure of a VHH isolated from a naïve phage display library. BMC Research Notes 12(1) . 10.1186/s13104-019-4197-0. [PDB: 6dyx] CMCF-ID Health
Whitesell, Luke; Robbins, Nicole; Huang, David S.; McLellan, Catherine A.; Shekhar-Guturja, Tanvi et al. (2019). Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications 10(1) , 402. 10.1038/s41467-018-08248-w. [PDB: 6cjl, 6cjp] CMCF-ID Health
Wrobleski, Stephen T.; Moslin, Ryan; Lin, Shuqun; Zhang, Yanlei; Spergel, Steven et al. (2019). Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. Journal of Medicinal Chemistry 62(20) . 10.1021/acs.jmedchem.9b00444. [PDB: 6nzq, 6nzr] CMCF-ID Health
Zhang, Birong; Kiefer, James R.; Blake, Robert A.; Chang, Jae H.; Hartman, Steven et al. (2019). Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorganic and Medicinal Chemistry Letters 29(7) . 10.1016/j.bmcl.2019.01.036. [PDB: 6dfn] CMCF-ID Health
Aamudalapalli, Hari Babu; Bertwistle, Drew; Palmer, David R.J.; Sanders, David A.R. (2018). myo-Inositol dehydrogenase and scyllo-inositol dehydrogenase from Lactobacillus casei BL23 bind their substrates in very different orientations. Biochimica et Biophysica Acta - Proteins and Proteomics 1866(11) , 1115-1124. 10.1016/j.bbapap.2018.08.011. CMCF-ID Health
Alexander, J. Andrew N.; Chatterjee, Som S.; Hamilton, Stephanie M.; Eltis, Lindsay D.; Chambers, Henry F. et al. (2018). Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus. Journal of Biological Chemistry 293(51) , 19854-19865. 10.1074/jbc.ra118.004952. [PDB: 5tw4, 5tw8, 5tx9, 5txi, 5ty2, 5ty7, 6c39, 6c3k] CMCF-BM, CMCF-ID Health
Arnal, Gregory; Stogios, Peter J.; Asohan, Jathavan; Skarina, Tatiana; Savchenko, Alexei et al. (2018). Structural enzymology reveals the molecular basis of substrate regiospecificity and processivity of an exemplar bacterial glycoside hydrolase family 74 endo-xyloglucanase. Biochemical Journal 475(24) , 3963-3978. 10.1042/bcj20180763. [PDB: 6mgl] CMCF-ID Health
Bagal, Sharan K.; Andrews, Mark; Bechle, Bruce M.; Bian, Jianwei; Bilsland, James et al. (2018). Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. Journal of Medicinal Chemistry 61(15) , 6779-6800. 10.1021/acs.jmedchem.8b00633. [PDB: 6dkb] CMCF-ID Health
Bagal, Sharan K.; Omoto, Kiyoyuki; Blakemore, David C.; Bungay, Peter J.; Bilsland, James G. et al. (2018). Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors. Journal of Medicinal Chemistry 62(1) , 247-265. 10.1021/acs.jmedchem.8b00280. [PDB: 6d20] CMCF-ID Health
Beyrakhova, Ksenia; Li, Lei; Xu, Caishuang; Gagarinova, Alla; Cygler, Miroslaw et al. (2018). Legionella pneumophila effector Lem4 is a membrane-associated protein tyrosine phosphatase. Journal of Biological Chemistry 293(34) , 13044-13058. 10.1074/jbc.ra118.003845. [PDB: 6cdw, 6cgj] CMCF-ID Health