Publication Beamlines Strategic Pillar
Duan, James J.-W.; Lu, Zhonghui; Jiang, Bin; Yang, Bingwei V.; Doweyko, Lidia M. et al. (2014). Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors. Bioorganic and Medicinal Chemistry Letters 24(24) , 5721-5726. 10.1016/j.bmcl.2014.10.061. [PDB: 4rio] CMCF-ID Health
Elliott, J.Michael; Ultsch, Mark; Lee, Joshua; Tong, Raymond; Takeda, Kentaro et al. (2014). Antiparallel Conformation of Knob and Hole Aglycosylated Half-Antibody Homodimers Is Mediated by a CH2–CH3 Hydrophobic Interaction. Journal of Molecular Biology 426(9) , 1947-1957. 10.1016/j.jmb.2014.02.015. [PDB: 4nqt] CMCF-ID Health
Gobeil, Sophie M.C.; Clouthier, Christopher M.; Park, Jaeok; Gagné, Donald; Berghuis, Albert M. et al. (2014). Maintenance of Native-like Protein Dynamics May Not Be Required for Engineering Functional Proteins. Chemistry & Biology 21(10) , 1330-1340. 10.1016/j.chembiol.2014.07.016. [PDB: 4id4] CMCF-ID Health
Grishin, Andrey M.; Cherney, Maia; Anderson, Deborah H.; Phanse, Sadhna; Babu, Mohan et al. (2014). NleH Defines a New Family of Bacterial Effector Kinases. Structure 22(2) , 250-259. 10.1016/j.str.2013.11.006. [PDB: 4lrj, 4lrk] CMCF-ID Health
Grishin, Andrey M.; Condos, Tara E.C.; Barber, Kathryn R.; Campbell-Valois, François-Xavier; Parsot, Claude et al. (2014). Structural Basis for the Inhibition of Host Protein Ubiquitination by Shigella Effector Kinase OspG. Structure 22(6) , 878-888. 10.1016/j.str.2014.04.010. [PDB: 4q5e, 4q5h] CMCF-ID Health
Gruninger, Robert J.; Thibault, John; Capeness, Michael J.; Till, Robert; Mosimann, Steven C. et al. (2014). Structural and Biochemical Analysis of a Unique Phosphatase from Bdellovibrio bacteriovorus Reveals Its Structural and Functional Relationship with the Protein Tyrosine Phosphatase Class of Phytase. PLoS ONE 9(4) , e94403. 10.1371/journal.pone.0094403. [PDB: 4nx8] CMCF-ID Health
Haji-Ghassemi, Omid; Müller-Loennies, Sven; Saldova, Radka; Muniyappa, Mohankumar; Brade, Lore et al. (2014). Groove-type Recognition of Chlamydiaceae-specific Lipopolysaccharide Antigen by a Family of Antibodies Possessing an Unusual Variable Heavy Chain N-Linked Glycan. Journal of Biological Chemistry 289(24) , 16644-16661. 10.1074/jbc.m113.528224. [PDB: 4m7j, 4m7z, 4m93, 4ma1] CMCF-ID Health
Hehemann, Jan-Hendrik; Law, Adrienne; Redecke, Lars; Boraston, Alisdair B. (2014). The Structure of RdDddP from Roseobacter denitrificans Reveals That DMSP Lyases in the DddP-Family Are Metalloenzymes. PLoS ONE 9(7) , e103128. 10.1371/journal.pone.0103128. [PDB: 4b28] CMCF-ID Materials
Huh, Ian; Gene, Robert; Kumaran, Jyothi; MacKenzie, C. Roger; Brooks, Cory L. et al. (2014). In situproteolysis, crystallization and preliminary X-ray diffraction analysis of a VHH that binds listeria internalin B. Acta Crystallographica Section F:Structural Biology Communications 70(11) , 1532-1535. 10.1107/s2053230x1402010x. CMCF-ID Health
Jacobson, Jared M.; Yin, Jiang; Kitov, Pavel I.; Mulvey, George; Griener, Tom P. et al. (2014). The Crystal Structure of Shiga Toxin Type 2 with Bound Disaccharide Guides the Design of a Heterobifunctional Toxin Inhibitor. Journal of Biological Chemistry 289(2) , 885-894. 10.1074/jbc.m113.518886. [PDB: 4m1u] CMCF-ID Health
Johnson, Ted W.; Richardson, Paul F.; Bailey, Simon; Brooun, Alexei; Burke, Benjamin J. et al. (2014). Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations. Journal of Medicinal Chemistry 57(11) , 4720-4744. 10.1021/jm500261q. [PDB: 4ctb] CMCF-ID Health
Kalynych, Sergei; Cherney, Maia; Bostina, Mihnea; Rouiller, Isabelle; Cygler, Miroslaw et al. (2014). Quaternary structure of WzzB and WzzE polysaccharide copolymerases. Protein Science 24(1) , 58-69. 10.1002/pro.2586. CMCF-ID Health
Keeling, Thomas J.; Samborska, Bożena; Demers, Ryan W.; Kimber, Matthew S. (2014). Interactions and structural variability of β-carboxysomal shell protein CcmL. Photosynthesis Research 121(2-3) , 125-133. 10.1007/s11120-014-9973-z. [PDB: 4n8f, 4n8x] CMCF-ID Agriculture
Keszei, Alexander F. A.; Tang, Xiaojing; McCormick, Craig; Zeqiraj, Elton; Rohde, John R. et al. (2014). Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase. Molecular and Cellular Biology 34(3) , 362-373. 10.1128/mcb.01360-13. [PDB: 4nkg] CMCF-ID Health
Kiefer, Susan E.; Chang, ChiehYing J.; Kimura, S. Roy; Gao, Mian; Xie, Dianlin et al. (2014). The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor. Acta Crystallographica Section F Structural Biology and Crystallization Communications 70(2) , 173-181. 10.1107/s2053230x14000144. [PDB: 4nfm] CMCF-ID Health