Publication Beamlines Strategic Pillar
Higgins, Melanie A.; Shi, Xinjie; Soler, Jordi; Harland, Jill B.; Parkkila, Taylor et al. (2025). Structure and mechanism of haem-dependent nitrogen–nitrogen bond formation in piperazate synthase. Nature Catalysis 8(3) , 207-217. 10.1038/s41929-024-01280-8. CMCF-ID Materials
Fraser, Bryan J.; Young, Nicholas J.; Bender, Brian J.; Gahbauer, Stefan; Ilyassov, Olzhas et al. (2025). Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors. Journal of Medicinal Chemistry 68(19) , 19893-19907. 10.1021/acs.jmedchem.4c03089. CMCF-ID Health
Fraser, Bryan J.; Wilson, Ryan P.; Ferková, Sára; Ilyassov, Olzhas; Lac, Jackie et al. (2025). Structural basis of TMPRSS11D specificity and autocleavage activation. Nature Communications 16(1) . 10.1038/s41467-025-59677-3. CMCF-ID Health
Puumala, Emily; Nandakumar, Meganathan; Yiu, Bonnie; Stogios, Peter J.; Strickland, Benjamin G. et al. (2025). Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans. Nature Communications 16(1) . 10.1038/s41467-025-57346-z. CMCF-ID Health
Nguyen, Quynh Huong; Lai, Chun Heng Royce; Norris, Michael J.; Ng, Dixon; Shah, Megha et al. (2025). A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion. PLoS Pathogens 21(5) , e1012686. 10.1371/journal.ppat.1012686. CMCF-ID Health
Ivanochko, Danton; Miura, Kazutoyo; Hailemariam, Sophia; Ravichandran, Rashmi; Song, Yiting et al. (2026). A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity. Nature Communications . 10.1038/s41467-026-68761-1. CMCF-ID Health
Govind, Manitabhai; Allas, Mikel Jason; Huang, Bo-Shun; Lowary, Todd L.; Kimber, Matthew S. et al. (2026). The retaining kdo transferase that synthesizes Escherichia coli K13 capsule is deeply divergent from structurally homologous enzymes. Journal of Biological Chemistry 302(3) , 111162. 10.1016/j.jbc.2026.111162. [PDB: 9yfx] CMCF-ID Health
Haines, Eric; Burke, Michael; Catterall, Rachel; De Jesus, Victor; Hidalgo, Daniel et al. (2026). The MEK–RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers. Nature Cancer . 10.1038/s43018-025-01081-3. [PDB: 9ecu] CMCF-ID Health
Kimani, Serah W.; Noureldin, Mahmoud; Wilson, Brian; Hoffer, Laurent; Green, Stuart R. et al. (2025). OICR-41103 as a chemical probe for the DCAF1 WD40 domain. Communications Biology 8(1) . 10.1038/s42003-025-08491-0. [PDB: 9yv4] CMCF-ID Health
Wang, Mingyu; Du, Grace; Yongo‐Luwawa, Charity; Lu, Angelina; Kinrade, Brett et al. (2025). Peptide‐based ligand antagonists block a Vibrio cholerae adhesin. FEBS Letters . 10.1002/1873-3468.70231. [PDB: 9y9w, 9ybq] CMCF-ID Health
Luo, Chuanyun; Paetzel, Mark (2025). Crystal structure of Escherichia coli type I signal peptidase P84A in complex with lipopeptide antibiotic arylomycin A2. Journal of Structural Biology 217(4) , 108260. 10.1016/j.jsb.2025.108260. [PDB: 9nlo] CMCF-ID Health
Ereño-Orbea, June; Pang, Lijuan; Sicard, Taylor; Nycholat, Corwin; Cui, Hong et al. (2025). Molecular Insights into the Engagement of High-Affinity Sialylated Ligands to Human CD22. JACS Au . 10.1021/jacsau.5c01013. [PDB: 9rm3, 9ro7, 9rob] CMCF-BM, CMCF-ID Health
Bekkering, Ezra T.; Yoo, Randy; Hailemariam, Sophia; Heide, Fabian; Ivanochko, Danton et al. (2025). Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity. Immunity . 10.1016/j.immuni.2025.09.014. [PDB: 9n7k] CMCF-ID Health
Hemmings, Mark; Zieliński, Michał; Golkar, Tolou; Blanchet, Jonathan; Pistofidis, Angelos et al. (2025). Enzyme-mediated aminoglycoside resistance without target mimicry. Communications Chemistry 8(1) . 10.1038/s42004-025-01666-0. [PDB: 9mgu] CMCF-ID Health
Abdoli, Amirabbas; Yang, Zhihan; Odeh‐Ahmed, Abdullah; Bednova, Olga; Lemieux, Bruno et al. (2025). Probing the extent of importin‐α targeting of the TAF8 NLS by eliminating its cationic net‐charge. Protein Science 34(9) . 10.1002/pro.70272. [PDB: 9cl8, 9cle, 9clf, 9clg] CMCF-ID Health