Publication Beamlines Strategic Pillar
Adachi, Kaoru; Manabe, Tomoyuki; Yamasaki, Takayuki; Suma, Akira; Orita, Takuya et al. (2024). Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety. Bioorganic and Medicinal Chemistry Letters 110, 129864. 10.1016/j.bmcl.2024.129864. [PDB: 8zh4] CMCF-ID Health
Aguilar, Eric N.; Sagar, Satish; Murray, Brandy R.; Rajesh, Christabelle; Lei, Eric K. et al. (2024). Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6. Molecular Cancer Therapeutics 23(6) , 836-853. 10.1158/1535-7163.mct-23-0868. [PDB: 8gkk, 8gkl] CMCF-ID Health
Ahmad, Shehryar; Tsang, Kara K; Sachar, Kartik; Quentin, Dennis; Tashin, Tahmid M et al. (2020). Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones. eLife 9. 10.7554/elife.62816. [PDB: 6xrr] CMCF-ID Health
Akaki, Tatsuo; Bessho, Yuki; Ito, Takashi; Fujioka, Shingo; Ubukata, Minoru et al. (2021). Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorganic and Medicinal Chemistry 44, 116283. 10.1016/j.bmc.2021.116283. [PDB: 7ebb] CMCF-ID Health
Ali, Mohamed G.; Wahba, Haytham M.; Igelmann, Sebastian; Cyr, Normand; Ferbeyre, Gerardo et al. (2024). Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR. Autophagy . 10.1080/15548627.2024.2353443. [PDB: 8t33, 8t4t] CMCF-BM, CMCF-ID Health
Alonzo, Diego A.; Chiche-Lapierre, Clarisse; Tarry, Michael J.; Wang, Jimin; Schmeing, T. Martin et al. (2020). Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis. Nature Chemical Biology 16(5) . 10.1038/s41589-020-0481-5. [PDB: 6ulz] CMCF-ID Health
Anderson, Alexander C.; Burnett, Alysha J.N.; Hiscock, Lana; Maly, Kenneth E.; Weadge, Joel T. et al. (2020). The Escherichia coli cellulose synthase subunit G (BcsG) is a Zn2+-dependent phosphoethanolamine transferase. Journal of Biological Chemistry 295(18) , 6225-6235. 10.1074/jbc.ra119.011668. [PDB: 6pcz, 6pd0] CMCF-ID Health
Asar, Radwa; Dhindwal, Poonam; Ruzzini, Antonio (2024). Structural and functional analysis of a bile salt hydrolase from the bison microbiome. Journal of Biological Chemistry 300(10) , 107769. 10.1016/j.jbc.2024.107769. [PDB: 8vrx] CMCF-ID Health
Bailey-Elkin, Ben A.; Knaap, Robert C. M.; De Silva, Anuradha; Boekhoud, Ilse M.; Mous, Sandra et al. (2023). Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis. PLoS Pathogens 19(12) , e1011872. 10.1371/journal.ppat.1011872. [PDB: 8ehn] CMCF-ID Health
Bateman, Thomas J.; Shah, Megha; Ho, Timothy Pham; Shin, Hyejin Esther; Pan, Chuxi et al. (2021). A Slam-dependent hemophore contributes to heme acquisition in the bacterial pathogen Acinetobacter baumannii. Nature Communications 12(1) . 10.1038/s41467-021-26545-9. [PDB: 7re4, 7rea, 7red] CMCF-BM, CMCF-ID Health
Beenstock, Jonah; Ona, Samara Mishelle; Porat, Jennifer; Orlicky, Stephen; Wan, Leo C. K. et al. (2020). A substrate binding model for the KEOPS tRNA modifying complex. Nature Communications 11(1) . 10.1038/s41467-020-19990-5. [PDB: 7kju] CMCF-ID Health
Beshore, Douglas C.; Adam, Gregory C.; Barnard, Richard J. O.; Burlein, Christine; Gallicchio, Steven N. et al. (2021). Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction. ACS Medicinal Chemistry Letters 12(4) , 540-547. 10.1021/acsmedchemlett.1c00074. [PDB: 7ltg] CMCF-ID Health
Bissegger, Lukas; Constantin, Theodora A.; Keles, Erhan; Raguž, Luka; Barlow-Busch, Isobel et al. (2024). Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling. Chemical Science . 10.1039/d4sc05459h. [PDB: 8twy] CMCF-ID Health
Boddington, Kelly F.; Soubeyrand, Eric; Van Gelder, Kristen; Casaretto, José A.; Perrin, Colby et al. (2021). Bibenzyl synthesis in Cannabis sativa L.. Plant Journal 109(3) . 10.1111/tpj.15588. [PDB: 7sgy] CMCF-ID Agriculture
Borsari, Chiara; Keles, Erhan; McPhail, Jacob A.; Schaefer, Alexander; Sriramaratnam, Rohitha et al. (2022). Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα. Journal of the American Chemical Society 144(14) . 10.1021/jacs.1c13568. [PDB: 7r9v, 7r9y] CMCF-ID Health