Publication Beamlines Strategic Pillar
Loewen, Peter C.; De Silva, P. Malaka; Donald, Lynda J.; Switala, Jacek; Villanueva, Jacylyn et al. (2018). KatG-Mediated Oxidation Leading to Reduced Susceptibility of Bacteria to Kanamycin. ACS Omega 3(4) , 4213-4219. 10.1021/acsomega.8b00356. [PDB: 6b9b] CMCF-ID Health
Lyons, Bronwyn; Lugo, Miguel R.; Carlin, Stephanie; Lidster, Taylor; Merrill, A. Rod et al. (2018). Characterization of the catalytic signature of Scabin toxin, a DNA-targeting ADP-ribosyltransferase. Biochemical Journal 475(1) , 225-245. 10.1042/bcj20170818. [PDB: 5tlb, 5uvq, 6apy] CMCF-ID Health
Mahoney, Sarah J.; Narayan, Sridhar; Molz, Lisa; Berstler, Lauren A.; Kang, Seong A. et al. (2018). A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nature Communications 9(1) . 10.1038/s41467-018-03035-z. [PDB: 6bt0] CMCF-ID Health
Mallette, Evan; Kimber, Matthew S. (2018). Structural and kinetic characterization of (S)-1-amino-2-propanol kinase from the aminoacetone utilization microcompartment of Mycobacterium smegmatis. Journal of Biological Chemistry 293(51) , 19909-19918. 10.1074/jbc.ra118.005485. [PDB: 6ef6] CMCF-ID Health
Mallette, Evan; Kimber, Matthew S. (2018). Structure and Kinetics of the S-(+)-1-Amino-2-propanol Dehydrogenase from the RMM Microcompartment of Mycobacterium smegmatis. Biochemistry 57(26) , 3780-3789. 10.1021/acs.biochem.8b00464. [PDB: 6ci8, 6ci9] CMCF-ID Health
Marshall, Jeremy D.S.; Mellor, Paul; Ruan, Xuan; Whitecross, Dielle E.; Moore, Stanley A. et al. (2018). Insight into the PTEN - p85α interaction and lipid binding properties of the p85α BH domain. Oncotarget 9(97) , 36975-36992. 10.18632/oncotarget.26432. [PDB: 6mrp] CMCF-BM, CMCF-ID Health
McAllister, Laura A.; Butler, Christopher R.; Mente, Scot; O’Neil, Steven V.; Fonseca, Kari R. et al. (2018). Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. Journal of Medicinal Chemistry 61(7) , 3008-3026. 10.1021/acs.jmedchem.8b00070. [PDB: 6bq0] CMCF-ID Health
Mellor, Paul; Marshall, Jeremy D. S.; Ruan, Xuan; Whitecross, Dielle E.; Ross, Rebecca L. et al. (2018). Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation. Scientific Reports 8(1) . 10.1038/s41598-018-25487-5. [PDB: 6d81, 6d82, 6d85, 6d86, 6d87] CMCF-BM, CMCF-ID Health
Ozer, Hatice Gulcin; El-Gamal, Dalia; Powell, Ben; Hing, Zachary A.; Blachly, James S. et al. (2018). BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discovery 8(4) , 458-477. 10.1158/2159-8290.cd-17-0902. [PDB: 5wma] CMCF-ID Health
Picard, Marie-Ève; Nisole, Audrey; Béliveau, Catherine; Sen, Stephanie; Barbar, Aline et al. (2018). Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana : Implications for inhibitor design. Insect Biochemistry and Molecular Biology 92, 84-92. 10.1016/j.ibmb.2017.11.011. [PDB: 6b02, 6b04, 6b06] CMCF-ID Health
Pluvinage, Benjamin; Grondin, Julie M.; Amundsen, Carolyn; Klassen, Leeann; Moote, Paul E. et al. (2018). Molecular basis of an agarose metabolic pathway acquired by a human intestinal symbiont. Nature Communications 9(1) . 10.1038/s41467-018-03366-x. [PDB: 5t9a, 5t9x, 5ta0, 5ta1, 5ta5, 5ta7, 5ta9] CMCF-BM, CMCF-ID Health
Qiu, Luping; Levine, Kymberly; Gajiwala, Ketan S.; Cronin, Ciarán N.; Nagata, Asako et al. (2018). Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers. PLoS ONE 13(6) , e0198374. 10.1371/journal.pone.0198374. [PDB: 6cz2, 6cz3] CMCF-ID Health
Reimer, Janice M.; Harb, Ingrid; Ovchinnikova, Olga G.; Jiang, Jessie; Whitfield, Chris et al. (2018). Structural Insight into a Novel Formyltransferase and Evolution to a Nonribosomal Peptide Synthetase Tailoring Domain. ACS Chemical Biology 13(11) , 3161-3172. 10.1021/acschembio.8b00739. [PDB: 6ci2, 6ci5] CMCF-ID Health
Sauvé, Véronique; Sung, George; Soya, Naoto; Kozlov, Guennadi; Blaimschein, Nina et al. (2018). Mechanism of parkin activation by phosphorylation. Nature Structural and Molecular Biology 25(7) , 623-630. 10.1038/s41594-018-0088-7. [PDB: 6djw, 6djx] CMCF-ID Health
Smith, Peter A.; Koehler, Michael F. T.; Girgis, Hany S.; Yan, Donghong; Chen, Yongsheng et al. (2018). Optimized arylomycins are a new class of Gram-negative antibiotics. Nature 561(7722) , 189-194. 10.1038/s41586-018-0483-6. [PDB: 6b88] CMCF-ID Health