Publication Beamlines Strategic Pillar
Saran, Anshu; Kim, Hey-Min; Manning, Ireland; Hancock, Mark A; Schmitz, Claus et al. (2024). Unveiling the molecular mechanisms of the type IX secretion system's response regulator: Structural and functional insights. PNAS Nexus 3(8) . 10.1093/pnasnexus/pgae316. [PDB: 8ted] CMCF-BM Health
Shurtleff, Valerie W.; Layton, Mark E.; Parish, Craig A.; Perkins, James J.; Schreier, John D. et al. (2024). Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.3c02248. [PDB: 8ute] CMCF-BM Health
Tian, Yuqing; Worrall, Liam J.; Sim, Lyann; Liu, Feng; Nasseri, Seyed A. et al. (2024). Cobalt as a Cofactor for α-Galactosaminidase-Catalyzed Cleavage of Blood Group Antigens. ACS Catalysis 14(17) , 13497-13508. 10.1021/acscatal.4c03643. [PDB: 9awt, 9ay8, 9ayu] CMCF-BM, CMCF-ID Health
Xu, Shangyi; Grochulski, Pawel; Tanaka, Takuji (2024). Structural basis for the allosteric behaviour and substrate specificity of Lactococcus lactis Prolidase. Biochimica et Biophysica Acta - Proteins and Proteomics 1872(3) , 141000. 10.1016/j.bbapap.2024.141000. CMCF-BM, CMCF-ID Health
Zhou, Yuebiao; Aliagas, Ignacio; Wang, Shumei; Li, Chun Sing; Liu, Zhiguo et al. (2024). Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis. Bioorganic and Medicinal Chemistry Letters , 130026. 10.1016/j.bmcl.2024.130026. [PDB: 9dc8, 9dc9] CMCF-BM Health
Callahan, Alex J.; Gandhesiri, Satish; Travaline, Tara L.; Lozano Salazar, Lia; Hanna, Stephanie et al. (2023). Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display. Environmental Science and Technology . 10.26434/chemrxiv-2023-x86xp. [PDB: 8f16, 8f17] CMCF-BM Health
Chen, Sizhu Amelia; Arutyunova, Elena; Lu, Jimmy; Khan, Muhammad Bashir; Rut, Wioletta et al. (2023). SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. ACS Central Science 9(4) , 696-708. 10.1021/acscentsci.3c00054. [PDB: 8djj, 8dk8, 8dkz] CMCF-BM Health
Fakih, Rayan; Goldstein, RobertH.; Kozlov, Guennadi; Gehring, Kalle (2023). Burst kinetics and CNNM binding are evolutionarily conserved properties of phosphatases of regenerating liver (PRL). Journal of Biological Chemistry , 103055. 10.1016/j.jbc.2023.103055. [PDB: 8ct8] CMCF-BM Health
Frigon, Léonie; Pascal, John M (2023). Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP. Nucleic Acids Research . 10.1093/nar/gkad1064. [PDB: 8sx1] CMCF-BM Health
Gui, Wenjun; Hang, Yumo; Cheng, Wang; Gao, Minqi; Wu, Jiaquan et al. (2023). Structural basis of CDK3 activation by cyclin E1 and inhibition by dinaciclib. Biochemical and Biophysical Research Communications 662, 126-134. 10.1016/j.bbrc.2023.04.026. CMCF-BM, CMCF-ID Health
McGregor, Alexandra K.; Chan, Anson C.K.; Schroeder, Megan D.; Do, Long T.M.; Saini, Gurpreet et al. (2023). A new member of the flavodoxin superfamily from Fusobacterium nucleatum that functions in heme trafficking and reduction of anaerobilin. Journal of Biological Chemistry 299(7) , 104902. 10.1016/j.jbc.2023.104902. [PDB: 8g64] CMCF-BM Health
McLeod, Matthew J.; Holyoak, Todd (2023). Biochemical, structural, and kinetic characterization of PPi‐dependent phosphoenolpyruvate carboxykinase from Propionibacterium freudenreichii. Proteins: Structure. Function and Bioinformatics . 10.1002/prot.26513. [PDB: 8e1u] CMCF-BM Health
McLeod, Matthew J.; Tran, Norman; McCluskey, Gregory D.; Gillis, Tom D.; Bearne, Stephen L. et al. (2023). A metal‐dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine‐5′‐triphosphate. Protein Science 32(6) . 10.1002/pro.4648. [PDB: 8fv6, 8fv7, 8fv8, 8fv9, 8fva, 8fvb] CMCF-BM Health
Penner, Tiffany V.; Cobo, Neil Lorente; Patel, Deepak T.; Patel, Dhruvin H.; Savchenko, Alexei et al. (2023). Structural characterization of the Sel1‐like repeat protein LceB from Legionella pneumophila. Protein Science . 10.1002/pro.4889. [PDB: 8sxq] CMCF-BM Health
Pérez-Vargas, Jimena; Worrall, Liam J.; Olmstead, Andrea D.; Ton, Anh-Tien; Lee, Jaeyong et al. (2023). A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants. Emerging Microbes and Infections 12(2) . 10.1080/22221751.2023.2246594. [PDB: 8cyu, 8cyz, 8sxr] CMCF-BM Health