Publication Beamlines Strategic Pillar
Mellouk, Abdelkader; Ngo, Kenny; Kezzo, Ahmad A.; Martini, Cyrielle; França, Tanos C. C. et al. (2026). Mechanism of trans-envelope bacterial polysaccharide secretion in Class-3 outer-membrane polysaccharide export (OPX) protein systems. Nature Communications . 10.1038/s41467-025-67321-3. CMCF-BM Health
Di Lello, Paola; Wells, Marta M.; Davis, Ben; Daniels, Zoe; Garner, Thomas P. et al. (2026). Targeting PTPN22 at Nonorthosteric Binding Sites─A Fragment Approach. ACS Omega . 10.1021/acsomega.5c11028. CMCF-BM Health
Thavalingam, Annoj; Cheng, Zhi; Garcia, Bianca; Huang, Xue; Shah, Megha et al. (2019). Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. Nature Communications 10(1) . 10.1038/s41467-019-10577-3. CMCF-BM Health
Lee, Eunjeong; Redzic, Jasmina S.; Gordon, Blaine; Saviola, Anthony J.; Tran, Norman et al. (2025). Streptococcus pneumoniae HtrA is a dynamic and monomeric virulence factor capable of forming larger oligomeric complexes. Protein Science 35(1) . 10.1002/pro.70411. CMCF-BM Health
Jaime-Garza, Maru; Waight, Andrew; Hudlikar, Manish; Eddins, Michael J.; Rasti, Elnaz S. et al. (2025). Structural Characterization of Linker Shielding in ADC Site-Specific Conjugates. Pharmaceutics 17(12) , 1568. 10.3390/pharmaceutics17121568. [PDB: 9z0f] CMCF-BM Health
Forrester, Taylor J. B.; Lin, Sicheng; Lowary, Todd L.; Kimber, Matthew S. (2025). WrtF from Rhizobium tropici CIAT 899 is a GT-A fold fucosyltransferase that binds its donor nonproductively. Proceedings of the National Academy of Sciences of the United States of America 122(44) . 10.1073/pnas.2512460122. [PDB: 9omh, 9omi] CMCF-BM, CMCF-ID Agriculture
Ereño-Orbea, June; Pang, Lijuan; Sicard, Taylor; Nycholat, Corwin; Cui, Hong et al. (2025). Molecular Insights into the Engagement of High-Affinity Sialylated Ligands to Human CD22. JACS Au . 10.1021/jacsau.5c01013. [PDB: 9ro7, 9rob] CMCF-BM, CMCF-ID Health
Uguen, Mélanie; Shell, Devan J.; Silva, Madhushika; Deng, Yu; Li, Fengling et al. (2025). Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells. Nature Communications 16(1) . 10.1038/s41467-025-57005-3. [PDB: 9cuw, 9cux] CMCF-BM Health
Rolfe, Nicolas; Myskiw, Dustin; Patton, Matthew T.; Forrester, Taylor J. B.; Kimber, Matthew S. et al. (2025). Sad from Proteobacteria is a Structurally Distinct ALDH3 Enzyme Specialized for the Oxidation of Steroidal Aldehydes. Biochemistry 64(17) , 3735-3744. 10.1021/acs.biochem.5c00213. [PDB: 9nxl] CMCF-BM Health
Rolfe, Nicolas; Schroeter, Kurt L.; Forrester, Taylor JB.; Kimber, Matthew S.; Seah, Stephen YK. et al. (2025). Sal is a proteobacterial bile acid aldolase that repurposes key thiolase catalytic residues for retroaldol cleavage of C5 steroid side chains. Journal of Biological Chemistry 301(8) , 110439. 10.1016/j.jbc.2025.110439. [PDB: 9myr] CMCF-BM Health
Zhao, Feipeng; Zhang, Shumin; Wang, Shuo; Reid, Joel W.; Xia, Wei et al. (2025). Anion sublattice design enables superionic conductivity in crystalline oxyhalides. Science 390(6769) , 199-204. 10.1126/science.adt9678. CMCF-BM, SXRMB Materials
Grondin, Julie M.; Duan, Da; Kirlin, Alyssa C.; Abe, Kento T.; Chitayat, Seth et al. (2017). Diverse modes of galacto-specific carbohydrate recognition by a family 31 glycoside hydrolase from Clostridium perfringens. PLoS ONE 12(2) , e0171606. 10.1371/journal.pone.0171606. CLS-APS, CMCF-BM Health
Hamdorf, Matthias; Imhof, Thomas; Bailey-Elkin, Ben; Betz, Janina; Theobald, Sebastian J et al. (2023). The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm. Journal of Molecular Cell Biology 15(10) . 10.1093/jmcb/mjad062. CMCF-BM Health
Dodda, Leela S.; Campos, Sebastien; Ciccone, David; Carreiro, Samantha; Leit, Silvana et al. (2025). Knowledge and Structure-Based Drug Design of 15-PGDH Inhibitors. Journal of Medicinal Chemistry 68(17) , 18436-18462. 10.1021/acs.jmedchem.5c01231. [PDB: 9pfl] CMCF-BM Materials
Barghash, Marim M.; Mabanglo, Mark F.; Hoff, Samuel E.; Brozdnychenko, Dmytro; Wong, Keith S. et al. (2025). Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure . 10.1016/j.str.2025.07.013. [PDB: 9mjp] CMCF-BM Health