Publication Beamlines Strategic Pillar
Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L. et al. (2025). Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor. Bioorganic and Medicinal Chemistry Letters 124, 130262. 10.1016/j.bmcl.2025.130262. [PDB: 9n9y] CMCF-BM Health
Tran, Norman; Frenette, Aaron; Holyoak, Todd (2025). Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases. Proceedings of the National Academy of Sciences of the United States of America 122(35) . 10.1073/pnas.2503549122. [PDB: 9ekk, 9ekm, 9ekn] CMCF-BM Health
Tran, Norman; Redzic, Jasmina S.; Eisenmesser, Elan Z.; Holyoak, Todd (2025). The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain. Acta Crystallographica Section F:Structural Biology Communications 81(4) . 10.1107/s2053230x25001219. [PDB: 9ect] CMCF-BM Health
Uguen, Mélanie; Shell, Devan J.; Silva, Madhushika; Deng, Yu; Li, Fengling et al. (2025). Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells. Nature Communications 16(1) . 10.1038/s41467-025-57005-3. [PDB: 9cuw, 9cux] CMCF-BM Health
Zhao, Feipeng; Zhang, Shumin; Wang, Shuo; Reid, Joel W.; Xia, Wei et al. (2025). Anion sublattice design enables superionic conductivity in crystalline oxyhalides. Science 390(6769) , 199-204. 10.1126/science.adt9678. CMCF-BM, SXRMB Materials
Ali, Mohamed G.; Wahba, Haytham M.; Igelmann, Sebastian; Cyr, Normand; Ferbeyre, Gerardo et al. (2024). Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR. Autophagy . 10.1080/15548627.2024.2353443. [PDB: 8t33, 8t4t] CMCF-BM, CMCF-ID Health
Bon, Christopher G.; Grigg, Jason C.; Lee, Jaeyong; Robb, Craig S.; Caveney, Nathanael A. et al. (2024). Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. Journal of Structural Biology 216(2) , 108086. 10.1016/j.jsb.2024.108086. [PDB: 8vbt, 8vbv, 8vbw] CMCF-BM Health
Depp, Charles T.; Goodman, Aaron J.; Blanchard, Peter.E.R.; Massimi, Scott E.; Reid, Joel W. et al. (2024). Potential for high-grade recovery of rare earth elements and cobalt from acid mine drainage via adsorption to precipitated manganese (IV) oxides. Chemosphere , 143144. 10.1016/j.chemosphere.2024.143144. BIOXAS-MAIN, CMCF-BM Environment
Després, Philippe C.; Dubé, Alexandre K.; Picard, Marie-Ève; Grenier, Jordan; Shi, Rong et al. (2024). Compensatory mutations potentiate constructive neutral evolution by gene duplication. Science 385(6710) , 770-775. 10.1126/science.ado5719. [PDB: 8vll, 8vlm] CMCF-BM, CMCF-ID Health
Langelier, Marie-France; Mirhasan, Manija; Gilbert, Karine; Sverzhinksy, Aleksandr; Furtos, Alexandra et al. (2024). PARP enzyme de novo synthesis of protein-free poly(ADP-ribose). Molecular Cell 84(24) , 4758-4773.e6. 10.1016/j.molcel.2024.10.024. [PDB: 9bpy, 9dmc] CMCF-BM Health
Lin, Funing; Mabanglo, Mark F.; Zhou, Jin Lin; Binepal, Gursonika; Barghash, Marim M. et al. (2024). Structure-Based Design and Development of Phosphine Oxides as a Novel Chemotype for Antibiotics that Dysregulate Bacterial ClpP Proteases. Journal of Medicinal Chemistry 67(17) , 15131-15147. 10.1021/acs.jmedchem.4c00773. [PDB: 8szm, 8szn] CMCF-BM Health
Lin, Lirong; Tresp, David S.; Spasyuk, Denis M.; Lalancette, Roger A.; Prokopchuk, Demyan E. et al. (2024). Accessing Ni(0) to Ni(IV) via nickel–carbon–phosphorus bond reorganization. Chemical Communications 60(6) , 674-677. 10.1039/d3cc04687g. CMCF-BM Materials
Mabanglo, Mark F.; Wilson, Brian; Noureldin, Mahmoud; Kimani, Serah W.; Mamai, Ahmed et al. (2024). Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity. Nature Communications 15(1) . 10.1038/s41467-024-54500-x. [PDB: 9b9h, 9b9t, 9b9w, 9ba2] CMCF-BM Health
Muna, Tasneem Hassan; Rutbeek, Nicole R; Horne, Julia; Lao, Ying W; Krokhin, Oleg V et al. (2024). The phage protein paratox is a multifunctional metabolic regulator of Streptococcus. Nucleic Acids Research . 10.1093/nar/gkae1200. [PDB: 8vsq] CMCF-BM Health
Nasseri, Seyed Amirhossein; Lazarski, Aleksander C.; Lemmer, Imke L.; Zhang, Chloe Y.; Brencher, Eva et al. (2024). An alternative broad-specificity pathway for glycan breakdown in bacteria. Nature . 10.1038/s41586-024-07574-y. [PDB: 8tdi] CMCF-BM Health