Publication Beamlines Strategic Pillar
Toure, Momar; Johnson, Theresa; Li, Bin; Schmidt, Ralf; Ma, Hong et al. (2023). Discovery of quinazoline HPK1 inhibitors with high cellular potency. Bioorganic and Medicinal Chemistry 92, 117423. 10.1016/j.bmc.2023.117423. [PDB: 8cij] CMCF-BM Health
Torres, Miguel A.; Hoffarth, Elesha; Eugenio, Luiz; Savtchouk, Julia; Chen, Xue et al. (2016). Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism. Journal of Biological Chemistry 291(45) , 23403-23415. 10.1074/jbc.m116.747261. [PDB: 5kn4, 5kpc, 5kpg] CMCF-BM Health
Tonkin, Michelle L.; Roques, Magali; Lamarque, Mauld H.; Pugnière, Martine; Douguet, Dominique et al. (2011). Host Cell Invasion by Apicomplexan Parasites: Insights from the Co-Structure of AMA1 with a RON2 Peptide. Science 333(6041) , 463-467. 10.1126/science.1204988. [PDB: 2y8s, 2y8t] CMCF-ID Health
Tonkin, Michelle L.; Crawford, Joanna; Lebrun, Maryse L.; Boulanger, Martin J. (2012). Babesia divergensandNeospora caninumapical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion. Protein Science 22(1) , 114-127. 10.1002/pro.2193. [PDB: 4apl] CMCF-ID Health
Tonkin, Michelle L.; Beck, Josh R.; Bradley, Peter J.; Boulanger, Martin J. (2014). The Inner Membrane Complex Sub-compartment Proteins Critical for Replication of the Apicomplexan Parasite Toxoplasma gondii Adopt a Pleckstrin Homology Fold. Journal of Biological Chemistry 289(20) , 13962-13973. 10.1074/jbc.m114.548891. CMCF-ID Health
Tokarski, John S.; Zupa-Fernandez, Adriana; Tredup, Jeffrey A.; Pike, Kristen; Chang, ChiehYing et al. (2015). Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. Journal of Biological Chemistry 290(17) , 11061-11074. 10.1074/jbc.m114.619502. [PDB: 4wov] CMCF-ID Health
Tokareva, Olena S.; Li, Kunhua; Travaline, Tara L.; Thomson, Ty M.; Swiecicki, Jean-Marie et al. (2023). Recognition and reprogramming of E3 ubiquitin ligase surfaces by α-helical peptides. Nature Communications 14(1) . 10.1038/s41467-023-42395-z. [PDB: 8ei4] CMCF-BM Health
Tian, Yuqing; Worrall, Liam J.; Sim, Lyann; Liu, Feng; Nasseri, Seyed A. et al. (2024). Cobalt as a Cofactor for α-Galactosaminidase-Catalyzed Cleavage of Blood Group Antigens. ACS Catalysis 14(17) , 13497-13508. 10.1021/acscatal.4c03643. [PDB: 9awt, 9ay8, 9ayu] CMCF-BM, CMCF-ID Health
Tian, Yuqing; Worrall, Liam J.; Sim, Lyann; Liu, Feng; Nasseri, Seyed A. et al. (2024). Cobalt as a Cofactor for α-Galactosaminidase-Catalyzed Cleavage of Blood Group Antigens. ACS Catalysis 14(17) , 13497-13508. 10.1021/acscatal.4c03643. [PDB: 9awt, 9ay8, 9ayu] CMCF-BM, CMCF-ID Health
Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L. et al. (2025). Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor. Bioorganic and Medicinal Chemistry Letters 124, 130262. 10.1016/j.bmcl.2025.130262. [PDB: 9n9y] CMCF-BM Health
Thi, Nhung Nguyen; Offen, Wendy A.; Shareck, François; Davies, Gideon J.; Doucet, Nicolas et al. (2014). Structure and Activity of the Streptomyces coelicolor A3(2) β-N-Acetylhexosaminidase Provides Further Insight into GH20 Family Catalysis and Inhibition. Biochemistry 53(11) , 1789-1800. 10.1021/bi401697j. [PDB: 4c7f] CMCF-ID Health
Thede, Gina L.; Arthur, David C.; Edwards, Ross A.; Buelow, Daelynn R.; Wong, Julia L. et al. (2011). Structure of the Periplasmic Stress Response Protein CpxP. Journal of Bacteriology 193(9) , 2149-2157. 10.1128/jb.01296-10. [PDB: 3qzc] CMCF-ID Health
Thai, Elaine; Murugan, Rajagopal; Binter, Špela; Burn Aschner, Clare; Prieto, Katherine et al. (2023). Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Reports 42(11) , 113330. 10.1016/j.celrep.2023.113330. [PDB: 8fb5] CMCF-ID Health
Tempel, Wolfram; Grabovec, Irina; MacKenzie, Farrell; Dichenko, Yaroslav V.; Usanov, Sergey A. et al. (2014). Structural characterization of human cholesterol 7α-hydroxylase. Journal of Lipid Research 55(9) , 1925-1932. 10.1194/jlr.m050765. CMCF-ID Health
Tebben, Andrew J.; Ruzanov, Maxim; Gao, Mian; Xie, Dianlin; Kiefer, Susan E. et al. (2016). Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity. Acta Crystallographica Section D: Structural Biology 72(5) , 658-674. 10.1107/s2059798316003624. [PDB: 5e8u] CMCF-ID Health