Publication Beamlines Strategic Pillar
Kuatsjah, Eugene; Verstraete, Meghan M.; Kobylarz, Marek J.; Liu, Alvin K.N.; Murphy, Michael E.P. et al. (2019). Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase. Journal of Biological Chemistry 294(35) , jbc.RA119.009428. 10.1074/jbc.ra119.009428. [PDB: 6ojt] CMCF-ID Health
Lu, Zhonghui; Duan, James J.-W.; Xiao, Haiyun; Neels, James; Wu, Dauh-Rurng et al. (2019). Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists. Bioorganic and Medicinal Chemistry Letters 29(16) . 10.1016/j.bmcl.2019.06.036. [PDB: 6p9f] CMCF-ID Health
Huang, Ji; Nguyen, Vinh H.; Hamblin, Karleigh A.; Maytum, Robin; van der Giezen, Mark et al. (2019). ATP-specificity of succinyl-CoA synthetase fromBlastocystis hominis. Acta Crystallographica Section D: Structural Biology 75(7) , 647-659. 10.1107/s2059798319007976. [PDB: 6no1, 6no2, 6no3, 6no4] CMCF-ID Health
Hobbs, Joanne K.; Pluvinage, Benjamin; Robb, Melissa; Smith, Steven P.; Boraston, Alisdair B. et al. (2019). Two complementary α-fucosidases from Streptococcus pneumoniae promote complete degradation of host-derived carbohydrate antigens. Journal of Biological Chemistry 294(34) , jbc.RA119.009368. 10.1074/jbc.ra119.009368. [PDB: 6or4] CMCF-BM, CMCF-ID Health
Rahfeld, Peter; Sim, Lyann; Moon, Haisle; Constantinescu, Iren; Morgan-Lang, Connor et al. (2019). An enzymatic pathway in the human gut microbiome that converts A to universal O type blood. Nature Microbiology 4(9) . 10.1038/s41564-019-0469-7. [PDB: 6n1a] CMCF-ID Health
Aggett, Rebecca; Mallette, Evan; Gilbert, Stephanie E.; Vachon, Melody A.; Schroeter, Kurt L. et al. (2019). The steroid side-chain–cleaving aldolase Ltp2–ChsH2DUF35 is a thiolase superfamily member with a radically repurposed active site. Journal of Biological Chemistry 294(31) , jbc.RA119.008889. 10.1074/jbc.ra119.008889. [PDB: 6ok1] CMCF-BM Health
Newson, JoshuaP.M.; Scott, NichollasE.; Yeuk Wah Chung, Ivy; Wong Fok Lung, Tania; Giogha, Cristina et al. (2019). Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways*. Molecular and Cellular Proteomics 18(6) , 1138-1156. 10.1074/mcp.ra118.001093. [PDB: 6cgi, 6dus] CMCF-BM, CMCF-ID Health
Mothersole, Robert G.; Macdonald, Marta; Kolesnikov, Maxim; Murphy, Michael E. P.; Wolthers, Kirsten R. et al. (2019). Structural insight into the high reduction potentials observed for Fusobacterium nucleatum flavodoxin. Protein Science 28(8) . 10.1002/pro.3661. [PDB: 6ohk] CMCF-BM Health
Bryan, Marian C.; Drobnick, Joy; Gobbi, Alberto; Kolesnikov, Aleksandr; Chen, Yongsheng et al. (2019). Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. Journal of Medicinal Chemistry 62(13) . 10.1021/acs.jmedchem.9b00439. [PDB: 6o9d] CMCF-ID Health
Spergel, Steven H.; Mertzman, Michael E.; Kempson, James; Guo, Junqing; Stachura, Sylwia et al. (2019). Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Medicinal Chemistry Letters 10(3) , 306-311. 10.1021/acsmedchemlett.8b00508. [PDB: 6ny4] CMCF-ID Health
Garside, E.L.; Whelan, T.A.; Stark, M.R.; Rader, S.D.; Fast, N.M. et al. (2019). Prp8 in a Reduced Spliceosome Lacks a Conserved Toggle that Correlates with Splicing Complexity across Diverse Taxa. Journal of Molecular Biology 431(14) . 10.1016/j.jmb.2019.04.047. [PDB: 6nqi] CMCF-ID Health
Riggs, Jennifer R.; Elsner, Jan; Cashion, Dan; Robinson, Dale; Tehrani, Lida et al. (2019). Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy. Journal of Medicinal Chemistry 62(9) , 4401-4410. 10.1021/acs.jmedchem.8b01869. [PDB: 6n6o] CMCF-ID Health
Caveney, Nathanael A.; Pavlin, Anja; Caballero, Guillermo; Bahun, Miha; Hodnik, Vesna et al. (2019). Structural Insights into Bacteriophage GIL01 gp7 Inhibition of Host LexA Repressor. Structure 27(7) . 10.1016/j.str.2019.03.019. [PDB: 6n7o] CMCF-BM, CMCF-ID Health
Tamura, Kazune; Foley, Matthew H.; Gardill, Bernd R.; Dejean, Guillaume; Schnizlein, Matthew et al. (2019). Surface glycan-binding proteins are essential for cereal beta-glucan utilization by the human gut symbiont Bacteroides ovatus. Cellular and Molecular Life Sciences 76(21) . 10.1007/s00018-019-03115-3. [PDB: 6e9b] CMCF-BM Health
Haji-Ghassemi, Omid; Yuchi, Zhiguang; Van Petegem, Filip (2019). The Cardiac Ryanodine Receptor Phosphorylation Hotspot Embraces PKA in a Phosphorylation-Dependent Manner. Molecular Cell 75(1) . 10.1016/j.molcel.2019.04.019. [PDB: 6mm6, 6mm7] CMCF-BM Health